Transcranial static magnetic stimulation is a novel noninvasive method of reduction of the cortical excitability in certain neurological diseases that, unlike ordinary transcranial magnetic stimulation, makes use of static magnetic fields generated by permanent magnets. The physical principle underlying transcranial magnetic stimulation is well known, that is, the Faradays law. By contrast, the physical mechanism that explains the interaction between neurons and static magnetic fields in transcranial static magnetic stimulation remains unclear, which makes it difficult to improve and fine tune the treatment. In the present work it is discussed the possibility that this mechanism might be the Lorentz force exerted on the ions flowing along the membrane channels of neurons. To support this hypothesis, a dimensional analysis it is carried out to compare the Larmor radius of the ions in the presence of a static magnetic field with the dimensions of the cross section of human axons and membrane channels in neurons. This analysis shows that whereas a moderate static magnetic field is not expected to affect the ion flux through axons, nevertheless it can affect the ion flux along membrane channels. The overall effect of the static magnetic field would be to introduce an additional friction between the ions and the walls of the membrane channels, thus reducing its conductance. Calculations performed by using a Hodgkin-Huxley model demonstrate that even a slight reduction of the conductance of the membrane channels can lead to the suppression of the action potential, thus inhibiting neuronal activity.
Impact of Brain Anisotropy on Transcranial Temporal Interference Stimulation: Numerical Analysis Toward Reliable Montage Optimization
Chiba University（千叶大学）；National Institute for Physiological Sciences（国立生理科学研究所）；SOKENDAI（日本综合研究大学院大学）；National Institutes of Natural Sciences（国立自然科学研究院）；Center for Frontier Medical Engineering, Chiba University（千叶大学前沿医学工程中心）
Application of the reciprocity theorem to EEG inversion and optimization of EEG-driven transcranial current stimulation (tCS, including tDCS, tACS, tRNS)
Group-Level and Personalized Optimization for the Insula and Hippocampus Focal Electric Field in Transcranial Temporal Interferential Stimulation: A Computational Study
Asymmetric Modular Pulse Synthesizer: A High-Power High-Granularity Electronics Solution for Transcranial Magnetic Stimulation with Practically Any Pulse Shape for Neural Activation Selectivity
An open-source framework for predicting ultrasound neuromodulation: bridging tissue elastomechanics and neuron firing dynamics
Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University（北卡罗来纳大学教堂山分校与北卡罗来纳州立大学联合生物医学工程系）
