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arXiv 1503.00555cs.ITmath.IT
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通过分组测试学习免疫缺陷图

Learning Immune-Defectives Graph through Group Tests

Abhinav Ganesan, Sidharth Jaggi, Venkatesh Saligrama

摘要:

本文论述了药物发现和病原体鉴定的统一问题的抽象。病原体鉴定涉及致病生物分子的鉴定。药物发现包括发现被称为先导化合物的化合物,这些化合物与致病蛋白质结合并最终抑制蛋白质的功能。本文将先导化合物抽象为抑制物,致病蛋白质抽象为缺陷物,“无效”化合物和非致病蛋白质的混合物抽象为正常物。缺陷者可以对测试中存在的抑制剂免疫。因此,含有缺陷的测试是阳性的,只要它不含有其“相关”抑制剂。本文的目标是以高概率识别缺陷、抑制剂及其“关联”,或者换句话说,通过组测试有效地学习免疫缺陷图(IDG)。我们提出了一个概率非自适应池化设计,一个概率两阶段自适应池化设计和解码算法学习IDG。对于两阶段自适应合并设计,我们证明了保证抑制剂,缺陷及其关联的回收率所需的测试数量的样本复杂性,即,上限超过所提议的下限,超出的倍数是项目数的对数乘法因子。对于非自适应池化设计太多,我们表明,上限超过建议的下限,最多的对数乘法因子的项目数。

英文摘要:

This paper deals with an abstraction of a unified problem of drug discovery and pathogen identification. Pathogen identification involves identification of disease-causing biomolecules. Drug discovery involves finding chemical compounds, called lead compounds, that bind to pathogenic proteins and eventually inhibit the function of the protein. In this paper, the lead compounds are abstracted as inhibitors, pathogenic proteins as defectives, and the mixture of "ineffective" chemical compounds and non-pathogenic proteins as normal items. A defective could be immune to the presence of an inhibitor in a test. So, a test containing a defective is positive iff it does not contain its "associated" inhibitor. The goal of this paper is to identify the defectives, inhibitors, and their "associations" with high probability, or in other words, learn the Immune Defectives Graph (IDG) efficiently through group tests. We propose a probabilistic non-adaptive pooling design, a probabilistic two-stage adaptive pooling design and decoding algorithms for learning the IDG. For the two-stage adaptive-pooling design, we show that the sample complexity of the number of tests required to guarantee recovery of the inhibitors, defectives, and their associations with high probability, i.e., the upper bound, exceeds the proposed lower bound by a logarithmic multiplicative factor in the number of items. For the non-adaptive pooling design too, we show that the upper bound exceeds the proposed lower bound by at most a logarithmic multiplicative factor in the number of items.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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