arXiv 0906.36542009-06-19q-bio.CBq-bio.SC

细胞表面受体直接梯度传感的准确性

Accuracy of direct gradient sensing by cell-surface receptors

Robert G. Endres, Ned S. Wingreen

备注：: 2 figures, 1 table; Prog Biophys Mol Biol, in press

摘要：

真核生物的趋化细胞能够利用细胞表面受体准确地感知浅的化学浓度梯度。这种感知能力是显著的，因为细胞必须能够在空间上分辨通过扩散随机到达细胞表面受体的颗粒数量的小分数差异。另一个挑战和不确定性的来源是，粒子一旦结合和释放，可能会重新结合相同或不同的受体，这增加了噪音，但没有提供任何关于环境的新信息。我们最近推导出梯度传感的基本物理限制，使用一个简单的球形细胞模型，但不包括明确的粒子受体动力学。在这里，我们使用的波动耗散定理（FDT）的基础上的方法来计算现实受体的梯度传感的准确性。我们推导出两个受体的分析结果，以及两个同轴的受体环，例如，在每个细胞极。对于现实的受体，我们发现，粒子重新绑定降低梯度传感的准确性，符合我们以前的结果。

英文摘要：

Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion. An additional challenge and source of uncertainty is that particles, once bound and released, may rebind the same or a different receptor, which adds to noise without providing any new information about the environment. We recently derived the fundamental physical limits of gradient sensing using a simple spherical-cell model, but not including explicit particle-receptor kinetics. Here, we use a method based on the fluctuation-dissipation theorem (FDT) to calculate the accuracy of gradient sensing by realistic receptors. We derive analytical results for two receptors, as well as two coaxial rings of receptors, e.g. one at each cell pole. For realistic receptors, we find that particle rebinding lowers the accuracy of gradient sensing, in line with our previous results.

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摘要：

英文摘要：

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