受体协同性对细菌弱梯度和强梯度趋化中甲基化动力学的影响
Effect of receptor cooperativity on methylation dynamics in bacterial chemotaxis with weak and strong gradient
摘要：
我们研究甲基化动力学的化学感受器作为一个{ \sl大肠杆菌}细胞在空间变化的化学引诱物环境中移动。我们考虑具有强和弱空间梯度的引诱剂浓度。在细胞沿梯度的上坡和下坡运动期间，我们测量受体簇的平均甲基化水平的时间变化。我们的数值模拟表明，甲基化动力学敏感地依赖于受体簇的大小和梯度的强度。在运行开始后的短时间内，甲基化动力学主要由通常与高受体活性相关的短运行控制。这导致在短时间内脱甲基化。但是对于中间或大时间，长运行起重要作用，并且取决于受体协同性或梯度强度，甲基化的定性变化在该时间范围内可以完全不同。对于弱梯度，无论是上坡还是下坡，在初始去甲基化之后，我们发现甲基化水平随着时间的推移而稳定地增加。类似的定性行为也观察到上坡运行期间的强梯度。然而，甲基化动力学下坡运行在强梯度显示高度非平凡的依赖于受体簇的大小。我们解释这种行为的结果之间的相互作用的信号网络的传感和适应模块。
英文摘要：
We study methylation dynamics of the chemoreceptors as an {\sl E.coli} cell moves around in a spatially varying chemo-attractant environment. We consider attractant concentration with strong and weak spatial gradient. During the uphill and downhill motion of the cell along the gradient, we measure the temporal variation of average methylation level of the receptor clusters. Our numerical simulations show that the methylation dynamics depends sensitively on the size of the receptor clusters and also on the strength of the gradient. At short times after the beginning of a run, the methylation dynamics is mainly controlled by short runs which are generally associated with high receptor activity. This results in demethylation at short times. But for intermediate or large times, long runs play an important role and depending on receptor cooperativity or gradient strength, the qualitative variation of methylation can be completely different in this time regime. For weak gradient, both for uphill and downhill runs, after the initial demethylation, we find methylation level increases steadily with time for all cluster sizes. Similar qualitative behavior is observed for strong gradient during uphill runs as well. However, the methylation dynamics for downhill runs in strong gradient show highly non-trivial dependence on the receptor cluster size. We explain this behavior as a result of interplay between the sensing and adaptation modules of the signaling network.
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