确认T细胞受体激活是数字的，而不是模拟的。因此，单个T细胞的细胞溶解能力与初始刺激强度无关
Confirmation that T cell receptor activation is digital, not analog. Hence individual T cell cytolytic capacity is independent of initial stimulation strength
摘要：
无论是通过降低配体浓度还是降低其亲和力来实现次优淋巴细胞刺激，初始TCR活化应答都可能是数字化的。我们现在知道培养的外周血单核细胞（PBMC），当被植物凝集素如伴刀豆球蛋白-A（Con-A）激活时，响应细胞是T细胞，并且早期转录和代谢变化与T细胞对与MHC蛋白（pMHC）复合的特异性肽的反应非常相似。罗宾斯很久以前就指出，凝集素激活的PBMC反应是数字化的。这已经在pMHC激活的T细胞中得到证实。因此，一般来说，单个T细胞的反应与初始信号强度无关。
英文摘要：
Whether a sub-optimum lymphocyte stimulus is achieved by lowering ligand concentration, or decreasing its affinity, initial TCR activation responses are likely to be digital. We now know for cultured peripheral blood mononuclear cells (PBMCs), when activated by plant lectins such as concanavalin-A (Con-A), that the responding cells are T cells, and that early transcriptional and metabolic changes closely resemble those found with T cells responding to specific peptides complexed to MHC proteins (pMHC). Robbins long ago showed that lectin-activated PBMC responses were digital. This has now been confirmed for pMHC-activated T cells. Hence, in general, responses of individual T cells are independent of initial signal strength.
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