T细胞受体的胸腺选择是一个极值问题
Thymic selection of T-cell receptors as an extreme value problem
摘要：
T淋巴细胞（T细胞）在活化时协调适应性免疫应答。T细胞活化需要其表面上的T细胞受体（TCR）与源自外源蛋白的短肽（p）足够强的结合，所述短肽（p）与主要组织相容性（MHC）基因产物（在抗原呈递细胞上展示）结合。在胸腺中选择多样性和自身耐受性T细胞库。我们将胸腺选择过程映射到一个极值问题，并为选定TCR的氨基酸组成（使其具有识别功能）提供了一个分析表达式。
英文摘要：
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility (MHC) gene products (displayed on antigen presenting cells). A diverse and self-tolerant T cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected TCRs (which enable its recognition functions).
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