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arXiv 0712.2483math.APmath.FA
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肿瘤生长自由边界问题的李群作用与定态解的稳定性分析

Lie Group Action and Stability Analysis of Stationary Solutions for a Free Boundary Problem Modelling Tumor Growth

Shangbin Cui

摘要:

本文研究了一个模拟非坏死性肿瘤生长的多维自由边界问题解的渐近性态。本文首先建立了Banach空间中具有局部李群作用的微分方程的一个一般结果,该作用将一个解映射成新解。我们证明了一个中心流形存在的线性化算子的谱在一定的假设下,而不假设的空间中定义的方程是$D_A(θ)$或$D_A(θ,\infty)$型。利用这一一般性结果并对定态自由边界问题线性化的谱进行细致分析,证明了:如果表面张力系数$γ$大于一个阈值$γ^\ast$,则唯一定态解是渐近稳定的模平移,只要表示营养物扩散时间与肿瘤细胞倍增时间之比的常数$c$足够小,而如果是$γ< γ^\ast$,那么这个定态解是不稳定的。

英文摘要:

In this paper we study asymptotic behavior of solutions for a multidimensional free boundary problem modelling the growth of nonnecrotic tumors. We first establish a general result for differential equations in Banach spaces possessing a local Lie group action which maps a solution into new solutions. We prove that a center manifold exists under certain assumptions on the spectrum of the linearized operator without assuming that the space in which the equation is defined is of either $D_A(θ)$ or $D_A(θ,\infty)$ type. By using this general result and making delicate analysis of the spectrum of the linearization of the stationary free boundary problem, we prove that if the surface tension coefficient $γ$ is larger than a threshold value $γ^\ast$ then the unique stationary solution is asymptotically stable modulo translations, provided the constant $c$ representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficiently small, whereas if $γ< γ^\ast$ then this stationary solution is unstable.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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