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arXiv 2005.02803math.AP
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具有趋化性的Cahn-Hilliard肿瘤生长模型的长时间动力学

Long-time Dynamics for a Cahn-Hilliard Tumor Growth Model with Chemotaxis

Harald Garcke, Sema Yayla

摘要:

描述肿瘤生长过程的数学模型已经由几位作者制定,以了解癌症如何发展并开发新的治疗方法。在这项研究中,目的是研究两相扩散界面模型的长期行为,该模型在[11]中提出,将肿瘤组织建模为癌细胞和健康细胞的混合物。到目前为止,对该模型长期行为的研究忽略了对肿瘤生长有重要影响的趋化性和主动转运。在本研究中,我们的主要目的是研究这个具有趋化性和主动运输的模型。证明了该问题弱解在全相空间$H^1 (Ω) \times L^2 (Ω)$中的渐近紧性结果。在质量守恒的相空间中建立了全局吸引子的存在性。我们还证明了全局吸引子等于源自驻点集的非稳定流形。此外,我们得到的整体吸引子具有有限的分形维数。

英文摘要:

Mathematical models that describe the tumor growth process have been formulated by several authors in order to understand how cancer develops and to develop new treatment approaches. In this study, it is aimed to investigate the long-time behavior of the two-phase diffuse-interface model, which was proposed in [11] to model a tumor tissue as a mixture of cancerous and healthy cells. Up to now, studies on the long-time behavior of this model have neglected chemotaxis and active transport, which have a significant effect on tumor growth. In this research, our main aim is to study this model with chemotaxis and active transport. We prove an asymptotic compactness result for the weak solutions of the problem in the whole phase-space $H^1 (Ω) \times L^2 (Ω)$. We establish the existence of the global attractor in a phase space denoted via mass conservation. We also prove that the global attractor equals to the unstable manifold emanating from the set of stationary points. Moreover, we obtain that the global attractor has a finite fractal dimension.

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