Theoretical and numerical analysis for a hybrid tumor model with diffusion depending on vasculature

Theoretical analysis for a PDE-ODE system related to a Glioblastoma tumor with vasculature

In this paper we study a PDE-ODE system as a simplification of a Glioblastoma model. Mainly, we prove the existence and uniqueness of global in time classical solution using a fixed point argument. Moreover, we show some stability results of the solution depending on some conditions on the parameters.

A Glioblastoma PDE-ODE model including chemotaxis and vasculature

In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes chemotaxis term directed to vasculature. First, we obtain some a priori estimates for the (possible) solutions of the model. In particular, under some conditions on the parameters, we obtain that the system does not develop blow-up at finite time. In addition, we design a fully discrete finite element scheme for the model which preserves some pointwise estimates of the continuous problem. Later, we make an adimensional study in order to reduce the number of parameters. Finally, we detect the mai…

Asymptotic stability for a free boundary tumor model with angiogenesis

In this paper, we study a free boundary problem modeling solid tumor growth with vasculature which supplies nutrients to the tumor; this is characterized in the Robin boundary condition. It was recently established [Discrete Cont. Dyn. Syst. 39 (2019) 2473-2510] that for this model, there exists a threshold value $μ^\ast$ such that the unique radially symmetric stationary solution is linearly stable under non-radial perturbations for $0<μ<μ^\ast$ and linearly unstable for $μ>μ^\ast$. In this paper we further study the nonlinear stability of the radially symmetric stationary solution, which int…

肿瘤在营养和药物影响下的演化的模型分析与模拟

Analysis and Simulation on a Model for the Evolution of Tumors under the Influence of Nutrient and Drug Application

本文研究了肿瘤生长的非线性偏微分方程模型，分析了营养和药物在肿瘤进展中的作用，并提出了一种收敛的数值方法来近似非线性偏微分方程组的解。

The Hele-Shaw asymptotics for mechanical models of tumor growth

Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical concepts. Another possible ingredient is the supply of nutrients through vasculature. The models can describe the tissue either at the level of cell densities, or at the scale of the solid tumor, in this latter case by means of a free boundary problem. Our first goal here is to formulate a free boundary model of Hele-Shaw type, a variant including growth terms,…

Parameter identification for nonlocal phase field models for tumor growth via optimal control and asymptotic analysis

We introduce the problem of parameter identification for a coupled nonlocal Cahn-Hilliard-reaction-diffusion PDE system stemming from a recently introduced tumor growth model. The inverse problem of identifying relevant parameters is studied here by relying on techniques from optimal control theory of PDE systems. The parameters to be identified play the role of controls, and a suitable cost functional of tracking-type is introduced to account for the discrepancy between some a priori knowledge of the parameters and the controls themselves. The analysis is carried out for several classes of mo…