Objectives. This study develops and validates a vacuum-based alpha irradiation platform to support preclinical radiobiology. We aim to demonstrate precise, independent control over incident energy, fluence rate, and spatiotemporal patterns, which are critical to the mechanisms underlying targeted alpha therapies and low-dose risk assessments.
Approach. A vacuum-based system with a radioactive alpha source was designed and fabricated. The platform provides independent modulation of: (i) temporal patterns via a programmable gate valve; (ii) fluence rate across two orders of magnitude by varying source-to-aperture distance (57 to 381 mm); (iii) incident energy (0 to 4.6 MeV) using adjustable absorption layers; and (iv) spatial distributions via a 3D motion stage. Temporal precision was assessed via synchronized audio-electronic recordings. Fluence rates and energies were validated using CR-39 detectors and Monte Carlo (MC) simulations. Spatial precision was verified through programmed continuous and discrete trajectories.
Main results. Validation experiments demonstrated high system fidelity. Measured irradiation durations deviated from programmed values by less than 0.3 s. Measured and computed fluence rates agreed within 3%. For energy validation, CR-39 track diameters matched MC model predictions within one standard deviation. Recorded spatial patterns and dimensions aligned well with programmed trajectories.
Significance. We successfully validated a versatile vacuum-based platform that overcomes energy-degradation constraints of gas-filled systems. By providing multi-parametric control over alpha-particle delivery, this system enables systematic investigation into how energy, dose rate, and spatiotemporal patterns influence radiobiological responses. This platform is poised to optimize targeted alpha therapies and refine radiation protection frameworks.
A software tool for parametric collimator creation for linac-based preclinical irradiation studies
Stanford University School of Medicine（斯坦福大学医学院）；University of Wisconsin–Madison（威斯康星大学麦迪逊分校）；University of Colorado Anschutz Medical Campus（科罗拉多大学安舒茨医学校区）
Low noise optimization of an electron beam current transformer for conventional radiotherapy up to ultra high dose rate irradiations
超高剂量率电子束，也称为FLASH放射治疗，在一些临床前癌症治疗研究中变得越来越重要。然而，由于在辐照会话期间使用的剂量率，迄今为止不存在实时剂量监测装置。在这项工作中，我们提出了一个束电流互感器（BCT）的发展，从铁磁组件的选择和实现的屏蔽的前端电子设计的基础上的跨阻抗电路，以执行低噪声优化的检测器。BCT样机能够监测1.2 \textmu A ~ 200 mA的束流，信号的上升时间常数优于20 ns，下降速率低于0.05 $\cdot$ s $^{-1}$。初步的现场测量也提出。目标是将实时测量射束电流的BCT系统与监测射束形状和位置的电离室相结合，以提供可靠的剂量监测系统。
Addressing respiratory gating latency for accurate pulse delivery in preclinical electron FLASH irradiation on a clinical linear accelerator
Stanford University School of Medicine（斯坦福大学医学院）；Varian Medical Systems（瓦里安医疗系统）；The University of Texas MD Anderson Cancer Center（德克萨斯大学安德森癌症中心）；University of California Irvine School of Medicine（加州大学欧文分校医学院）
Commissioning of a clinical pencil beam scanning proton therapy unit for ultrahigh dose rates (FLASH)
目的：这项工作的目的是提供一个灵活的平台，通过调整以前的临床笔形束扫描机架的照射剂量率与质子的FLASH研究。方法：PSI机架1治疗患者直至2018年12月。我们优化了光束线参数，以将从PSI COMET加速器提取的250 MeV光束传输到治疗室，最大限度地提高光束强度到样品的传输。我们的特点是剂量监测器的机架上，以确保良好的控制剂量，提供点扫描模式。我们的特点是不同的剂量率和字段大小的传输辐照的光束。我们探索了扫描的可能性，以使大目标的共形辐射或透射辐射（横向扫描）。结果：我们实现了从回旋加速器到治疗室的86%的传输。我们达到了9000 Gy/s的峰值剂量率在3毫米水当量深度，沿一个单一的笔形束的中心轴。单点闪光照射可实现高达5 × 5 mm $^{2}$的射野尺寸。快速横向扫描可覆盖16 x 1.2 cm $^{2}$的视野。通过使用安装在桅杆上的量程转换器，我们能够在19.6至37.9厘米的水中跨越深度。输送的各种剂量水平的精度小于1%。结论：我们已经实现了一个质子FLASH照射设置能够连续调查宽剂量率谱，从1到9000 Gy/s的单点照射，以及在笔形束扫描模式。因此，我们已经开发了一个多功能的测试平台，闪存的研究。
Non-invasive Reversible Software-based Electron FLASH Irradiation Configuration of a Linear Accelerator in Clinical Use
Stanford University School of Medicine（斯坦福大学医学院）；University of California Irvine（加州大学尔湾分校）；Princess Margaret Cancer Centre, University Health Network（公主玛格丽特癌症中心，联合健康网络）
A volumetric Modulated Arc Therapy (VMAT) combined with deep inspiration breath hold (DIBH) technique for adjuvant irradiation for left sided breast cancer
Technical Note: Low-Dose Simulation for Grating-Based X-Ray Dark-Field Radiography Using a Virtually Decreased Irradiation Area
Technical University of Munich（慕尼黑工业大学）；Munich Institute of Biomedical Engineering（慕尼黑生物医学工程研究所）；Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, TUM Klinikum, Technical University of Munich (TUM)（慕尼黑工业大学TUM医院医学院与健康学院诊断与介入放射学研究所）；Philips Innovative Technologies（飞利浦创新技术）；Munich Institute for Advanced Study, Technical University of Munich（慕尼黑工业大学高级研究院）
External beam irradiation angle measurement using Cerenkov emission I: Signal dependencies consideration
本研究介绍了一种新型的混合切伦科夫闪烁剂量计，其目的是用于照射角度测量的切伦科夫角度依赖性的基础上。第一测量旨在通过同时测量沉积剂量来验证解释切伦科夫电子能谱依赖性的能力，从而隔离由角度依赖性引起的信号变化。切伦科夫探头是由一个10毫米长的透明PMMA光纤的敏感体积由一个吸收过滤器从1毫米直径的传输光纤分离。使用Hyperscint RP-200闪烁剂量测定平台分别收集来自敏感体积和传输光纤的过滤和原始Cerenkov信号。使用高光谱方法对总信号进行解混。用光子和电子束完成探测器信号的剂量校准。使用固体水模型，在固定的入射角，涵盖了广泛的剂量和输出因子的测量实现。对于固定的入射角，切伦科夫检测器的信号表征显示线性剂量-光关系。正如预期的那样，发现灵敏体积信号是能量依赖性的。对于高达25 cm x 25 cm的场尺寸，使用光子和电子，输出因子精确测量在0.8%以内。第一次验证的切伦科夫角度依赖性显示了一个线性的剂量-光的关系，为整个范围内的角度测试。正如预期的那样，由于角度依赖性，每剂量单位的切伦科夫信号强度基于照射角度而变化。结果表明，使用电子能谱类似于测量条件的校准条件允许依赖于沉积剂量来解释这种依赖性。这些初步结果构成了实验照射角测量的第一步。
Controlled kHz laser-driven electron irradiations for pre-clinical applications
ELI Beamlines Facility, The ELI ERIC（欧洲极亮激光设施）；U.O.S.D. Fisica Sanitaria e Radioterapia, ASP Trapani（特拉帕尼卫生局卫生物理与放射治疗科）；ELI-ALPS Research Institute, ELI-HU Non-Profit Ltd.（欧洲极亮激光阿尔萨斯研究所）；Faculty of Information Technology, Czech Technical University in Prague（布拉格捷克理工大学信息技术学院）；Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague（布拉格捷克理工大学核科学与物理工程学院）
Dependence of the Radical Dynamics on the Beam Temporal Profile in FLASH Radiotherapy
State Key Laboratory of Nuclear Physics and Technology and Institute of Heavy Ion Physics, School of Physics, Peking University（北京大学物理学院重离子物理研究所核物理与技术国家重点实验室）；Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute（北京大学肿瘤医院暨肿瘤研究所放射肿瘤科教育部癌变与转化研究重点实验室）；Department of Health Technology and Informatics, The Hong Kong Polytechnic University（香港理工大学健康技术与信息学系）；Beijing Laser Acceleration Innovation Center（北京激光加速器创新中心）；State Key Laboratory of Heavy Oil Processing, China University of Petroleum（中国石油大学（华东）重油加工国家重点实验室）；Guangdong Institute of Laser Plasma Accelerator Technology（广东激光等离子体加速器技术研究所）
