通过共聚焦成像探测全身照射引起的肠细胞核中DNA特定空间质量密度波动
Photonics probing of DNA specific spatial mass density fluctuations in gut cell nuclei due to total body irradiation via confocal imaging
摘要：
细胞内的异常导致纳米级结构改变，可以通过共聚焦成像和这些改变的定量来表征。意外或故意暴露于全身照射（TBI）会对细胞核DNA产生不利影响。在这里，我们研究的DNA分子质量密度的空间结构的改变，染色质在肠组织细胞核中所造成的暴露于标准剂量的4Gy TBI，使用光定位技术称为逆参与比（IPR）在共聚焦图像。结果表明，辐射抑制DNA空间质量密度波动。因此，减少和饱和的DNA密度波动观察到不同的持续时间的照射后。
英文摘要：
Abnormalities within cells result in nanoscale structural alterations can be characterized via confocal imaging and quantification of these alterations. Accidental or deliberate exposure to total body irradiation (TBI) have adverse effects on the nuclear DNAs of cells. Here, we study the DNA molecular mass density spatial structural alterations of chromatin in cell nuclei of gut tissues caused by the exposure to standard doses of 4Gy TBI, using the light localization technique called inverse participation ratio (IPR) in confocal images. Results indicate radiation suppresses DNA spatial mass density fluctuations. And hence, reduction and saturation in DNA density fluctuations are observed for different durations of post-irradiation.
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