We propose a method to improve the generalization of skin lesion classification models by combining self-supervised learning (SSL) and active domain adaptation (ADA). The main steps of the approach include selection of an SSL pre-trained model on natural image datasets, subsequent SSL retraining on all available skin-lesion datasets, fine-tuning of the model on source domain data with labels, and application of ADA methods on target domain data. The efficacy of the proposed approach is assessed in ten skin lesion datasets with five different ADA methods, demonstrating its potential to improve generalization in settings with different amounts of domain shifts.
Federal University of Espirito Santo, UFES（圣埃斯皮里图联邦大学（UFES））
Skin cancer is one of the most common types of cancer in the world. Different computer-aided diagnosis systems have been proposed to tackle skin lesion diagnosis, most of them based in deep convolutional neural networks. However, recent advances in computer vision achieved state-of-art results in many tasks, notably Transformer-based networks. We explore and evaluate advances in computer vision architectures, training methods and multimodal feature fusion for skin lesion diagnosis task. Experiments show that PiT ($0.800 \pm 0.006$), CoaT ($0.780 \pm 0.024$) and ViT ($0.771 \pm 0.018$) backbone…
Institute of Computing (IC)（计算学院）；School of Electrical and Computing Engineering (FEEC)（电气与计算工程学院）；RECOD Lab.（RECOD实验室）；University of Campinas (UNICAMP)（坎皮纳斯大学）
Louisiana State University in Shreveport（路易斯安那州立大学什里夫波特分校）；Kitware（Kitware公司）；Memorial Sloan-Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）；Missouri University of Science and Technology（密苏里科技大学）；Emory University（埃默里大学）；IBM T. J. Watson Research Center（IBM托马斯·J·沃森研究中心）
In this article, we describe the design and implementation of a publicly accessible dermatology image analysis benchmark challenge. The goal of the challenge is to sup- port research and development of algorithms for automated diagnosis of melanoma, a lethal form of skin cancer, from dermoscopic images. The challenge was divided into sub-challenges for each task involved in image analysis, including lesion segmentation, dermoscopic feature detection within a lesion, and classification of melanoma. Training data included 900 images. A separate test dataset of 379 images was provided to measure …
Privileged Lesion-Context Relational Distillation for Mask-Free Skin Lesion Classification
Victoria University（维多利亚大学）；Bangaldesh University of Business and Technology（孟加拉国商业与技术大学）；Daffodil Institute of Information Technology（达芙妮信息技术学院）；American International University-Bangladesh (AIUB)（孟加拉国美国国际大学）；Multimedia University（多媒体大学）
University of British Columbia（不列颠哥伦比亚大学）；Simon Fraser University（西蒙弗雷泽大学）
Deep learning models have achieved great success in automating skin lesion diagnosis. However, the ethnic disparity in these models' predictions, where lesions on darker skin types are usually underrepresented and have lower diagnosis accuracy, receives little attention. In this paper, we propose FairDisCo, a disentanglement deep learning framework with contrastive learning that utilizes an additional network branch to remove sensitive attributes, i.e. skin-type information from representations for fairness and another contrastive branch to enhance feature extraction. We compare FairDisCo to t…
Data-driven models are now deployed in a plethora of real-world applications - including automated diagnosis - but models learned from data risk learning biases from that same data. When models learn spurious correlations not found in real-world situations, their deployment for critical tasks, such as medical decisions, can be catastrophic. In this work we address this issue for skin-lesion classification models, with two objectives: finding out what are the spurious correlations exploited by biased networks, and debiasing the models by removing such spurious correlations from them. We perform…
Hamburg University of Technology（汉堡工业大学）；Forschungszentrum Medizintechnik Hamburg（汉堡医疗技术研究中心）；University Medical Center Hamburg-Eppendorf（汉堡-埃彭多夫大学医学中心）
In this paper, we describe our method for the ISIC 2019 Skin Lesion Classification Challenge. The challenge comes with two tasks. For task 1, skin lesions have to be classified based on dermoscopic images. For task 2, dermoscopic images and additional patient meta data have to be used. A diverse dataset of 25000 images was provided for training, containing images from eight classes. The final test set contains an additional, unknown class. We address this challenging problem with a simple, data driven approach by including external data with skin lesions types that are not present in the train…
In this paper, we studied extensively on different deep learning based methods to detect melanoma and skin lesion cancers. Melanoma, a form of malignant skin cancer is very threatening to health. Proper diagnosis of melanoma at an earlier stage is crucial for the success rate of complete cure. Dermoscopic images with Benign and malignant forms of skin cancer can be analyzed by computer vision system to streamline the process of skin cancer detection. In this study, we experimented with various neural networks which employ recent deep learning based models like PNASNet-5-Large, InceptionResNetV…
Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Indian Institute of Technology Jodhpur（焦特布尔印度理工学院）
Early detection and segmentation of skin lesions is crucial for timely diagnosis and treatment, necessary to improve the survival rate of patients. However, manual delineation is time consuming and subject to intra- and inter-observer variations among dermatologists. This underlines the need for an accurate and automatic approach to skin lesion segmentation. To tackle this issue, we propose a multi-task convolutional neural network (CNN) based, joint detection and segmentation framework, designed to initially localize the lesion and subsequently, segment it. A `Faster region-based convolutiona…
Medical University of Vienna（维也纳医科大学）；University of Queensland（昆士兰大学）
Training of neural networks for automated diagnosis of pigmented skin lesions is hampered by the small size and lack of diversity of available datasets of dermatoscopic images. We tackle this problem by releasing the HAM10000 ("Human Against Machine with 10000 training images") dataset. We collected dermatoscopic images from different populations acquired and stored by different modalities. Given this diversity we had to apply different acquisition and cleaning methods and developed semi-automatic workflows utilizing specifically trained neural networks. The final dataset consists of 10015 der…
Pakistan Navy Engineering College (PNEC)（巴基斯坦海军工程学院）；National University of Sciences & Technology (NUST)（国家科技大学）；Electronics and Power Engineering (EPE)（电子与动力工程系）
Technology aided platforms provide reliable tools in almost every field these days. These tools being supported by computational power are significant for applications that need sensitive and precise data analysis. One such important application in the medical field is Automatic Lesion Detection System (ALDS) for skin cancer classification. Computer aided diagnosis helps physicians and dermatologists to obtain a second opinion for proper analysis and treatment of skin cancer. Precise segmentation of the cancerous mole along with surrounding area is essential for proper analysis and diagnosis. …
Nanyang Technological University（南洋理工大学）；Central South University（中南大学）；Singapore University of Technology and Design（新加坡科技设计大学）
Deep learning techniques have shown their superior performance in dermatologist clinical inspection. Nevertheless, melanoma diagnosis is still a challenging task due to the difficulty of incorporating the useful dermatologist clinical knowledge into the learning process. In this paper, we propose a novel knowledge-aware deep framework that incorporates some clinical knowledge into collaborative learning of two important melanoma diagnosis tasks, i.e., skin lesion segmentation and melanoma recognition. Specifically, to exploit the knowledge of morphological expressions of the lesion region and …
DERM12345: A Large, Multisource Dermatoscopic Skin Lesion Dataset with 38 Subclasses
Imperial College London（帝国理工学院）；The University of Health Sciences（健康科学大学）；Haydarpasa Numune Research and Training Hospital（海达尔帕夏努穆内研究与培训医院）；Istinye University（伊斯坦布尔伊斯坦尼耶大学）；Liv Hospital Vadistanbul（瓦迪斯坦布尔丽芙医院）
Microsoft（微软）；Cupertino High School（库比蒂诺高中）；Inglemoor High School（英格尔穆尔高中）
All datasets contain some biases, often unintentional, due to how they were acquired and annotated. These biases distort machine-learning models' performance, creating spurious correlations that the models can unfairly exploit, or, contrarily destroying clear correlations that the models could learn. With the popularity of deep learning models, automated skin lesion analysis is starting to play an essential role in the early detection of Melanoma. The ISIC Archive is one of the most used skin lesion sources to benchmark deep learning-based tools. Bissoto et al. experimented with different boun…
The segmentation of skin lesions is a crucial task in clinical decision support systems for the computer aided diagnosis of skin lesions. Although deep learning-based approaches have improved segmentation performance, these models are often susceptible to class imbalance in the data, particularly, the fraction of the image occupied by the background healthy skin. Despite variations of the popular Dice loss function being proposed to tackle the class imbalance problem, the Dice loss formulation does not penalize misclassifications of the background pixels. We propose a novel metric-based loss f…
The iToBoS dataset: skin region images extracted from 3D total body photographs for lesion detection
Computer Vision and Robotics Research Institute, University of Girona（赫罗纳大学计算机视觉与机器人研究所）；Hospital Clínic Barcelona, Universitat de Barcelona（巴塞罗那大学巴塞罗那临床医院）；Frazer Institute, The University of Queensland（昆士兰大学弗雷泽研究所）；University of Trieste（的里雅斯特大学）；ISAHIT；Canfield Scientific, Inc.（坎菲尔德科学公司）；HUN-REN Institute for Computer Science and Control（HUN-REN计算机科学与控制研究所）
University of Science and Technology of China（中国科学技术大学）；The Ohio State University Medical Center（俄亥俄州立大学医学中心）
Deep convolutional neural network (DCNN) models have been widely explored for skin disease diagnosis and some of them have achieved the diagnostic outcomes comparable or even superior to those of dermatologists. However, broad implementation of DCNN in skin disease detection is hindered by small size and data imbalance of the publically accessible skin lesion datasets. This paper proposes a novel single-model based strategy for classification of skin lesions on small and imbalanced datasets. First, various DCNNs are trained on different small and imbalanced datasets to verify that the models w…
Effective Attention-Guided Multi-Scale Medical Network for Skin Lesion Segmentation
Business University Yantai, China（烟台 business 大学）；Artificial Intelligence Ludong University Yantai, China（人工智能 岭东大学）；Engineering Shandong University of Finance（工程 山东财经大学）
This paper summarizes our method and validation results for the ISIC Challenge 2018 - Skin Lesion Analysis Towards Melanoma Detection - Task 1: Lesion Segmentation
This paper summarizes our method and validation results for the ISBI Challenge 2017 - Skin Lesion Analysis Towards Melanoma Detection - Part I: Lesion Segmentation
We present a deep learning approach to the ISIC 2017 Skin Lesion Classification Challenge using a multi-scale convolutional neural network. Our approach utilizes an Inception-v3 network pre-trained on the ImageNet dataset, which is fine-tuned for skin lesion classification using two different scales of input images.
This article presents the design, experiments and results of our solution submitted to the 2018 ISIC challenge: Skin Lesion Analysis Towards Melanoma Detection. We design a pipeline using state-of-the-art Convolutional Neural Network (CNN) models for a Lesion Boundary Segmentation task and a Lesion Diagnosis task.
Our system addresses Part 1, Lesion Segmentation and Part 3, Lesion Classification of the ISIC 2017 challenge. Both algorithms make use of deep convolutional networks to achieve the challenge objective.
Isfahan University of Technology（伊斯法罕理工大学）；University of British Columbia（不列颠哥伦比亚大学）；University of Michigan（密歇根大学）；McMaster University（麦克马斯特大学）
One of the essential tasks in medical image analysis is segmentation and accurate detection of borders. Lesion segmentation in skin images is an essential step in the computerized detection of skin cancer. However, many of the state-of-the-art segmentation methods have deficiencies in their border detection phase. In this paper, a new class of fully convolutional network is proposed, with new dense pooling layers for segmentation of lesion regions in skin images. This network leads to highly accurate segmentation of lesions on skin lesion datasets which outperforms state-of-the-art algorithms …
In this paper we approach the problem of skin lesion segmentation using a convolutional neural network based on the U-Net architecture. We present a set of training strategies that had a significant impact on the performance of this model. We evaluated this method on the ISIC Challenge 2018 - Skin Lesion Analysis Towards Melanoma Detection, obtaining threshold Jaccard index of 77.5%.
Skin lesion identification is a key step toward dermatological diagnosis. When describing a skin lesion, it is very important to note its body site distribution as many skin diseases commonly affect particular parts of the body. To exploit the correlation between skin lesions and their body site distributions, in this study, we investigate the possibility of improving skin lesion classification using the additional context information provided by body location. Specifically, we build a deep multi-task learning (MTL) framework to jointly optimize skin lesion classification and body location cla…
Shanghai Jiao Tong University（上海交通大学）；École de technologie supérieure, Université du Québec（魁北克大学高等技术学院）；University of Leicester（莱斯特大学）
Skin lesion detection in dermoscopic images is essential in the accurate and early diagnosis of skin cancer by a computerized apparatus. Current skin lesion segmentation approaches show poor performance in challenging circumstances such as indistinct lesion boundaries, low contrast between the lesion and the surrounding area, or heterogeneous background that causes over/under segmentation of the skin lesion. To accurately recognize the lesion from the neighboring regions, we propose a dilated scale-wise feature fusion network based on convolution factorization. Our network is designed to simul…
University of Burgundy（勃艮第大学）；University of Cassino（卡西诺大学）；University of Girona（赫罗纳大学）
Skin lesion segmentation is one of the first steps towards automatic Computer-Aided Diagnosis of skin cancer. Vast variety in the appearance of the skin lesion makes this task very challenging. The contribution of this paper is to apply a power foreground extraction technique called GrabCut for automatic skin lesion segmentation with minimal human interaction in HSV color space. Preprocessing was performed for removing the outer black border. Jaccard Index was measured to evaluate the performance of the segmentation method. On average, 0.71 Jaccard Index was achieved on 1000 images from ISIC c…
In this study, we investigate what a practically useful approach is in order to achieve robust skin disease diagnosis. A direct approach is to target the ground truth diagnosis labels, while an alternative approach instead focuses on determining skin lesion characteristics that are more visually consistent and discernible. We argue that, for computer-aided skin disease diagnosis, it is both more realistic and more useful that lesion type tags should be considered as the target of an automated diagnosis system such that the system can first achieve a high accuracy in describing skin lesions, an…
There has been a steady increase in the incidence of skin cancer worldwide, with a high rate of mortality. Early detection and segmentation of skin lesions are crucial for timely diagnosis and treatment, necessary to improve the survival rate of patients. However, skin lesion segmentation is a challenging task due to the low contrast of lesions and their high similarity in terms of appearance, to healthy tissue. This underlines the need for an accurate and automatic approach for skin lesion segmentation. To tackle this issue, we propose a convolutional neural network (CNN) called SkinNet. The …
In this work, we explore the issue of the inter-annotator agreement for training and evaluating automated segmentation of skin lesions. We explore what different degrees of agreement represent, and how they affect different use cases for segmentation. We also evaluate how conditioning the ground truths using different (but very simple) algorithms may help to enhance agreement and may be appropriate for some use cases. The segmentation of skin lesions is a cornerstone task for automated skin lesion analysis, useful both as an end-result to locate/detect the lesions and as an ancillary task for …
This paper summarizes our method and validation results for part 1 of the ISBI Challenge 2018. Our algorithm makes use of deep encoder-decoder network and novel skin lesion data augmentation to segment the challenge objective. Besides, we also propose an effective testing strategy by applying multi-model comparison.
This paper describes the participation of Araguaia Medical Vision Lab at the International Skin Imaging Collaboration 2017 Skin Lesion Challenge. We describe the use of deep convolutional neural networks in attempt to classify images of Melanoma and Seborrheic Keratosis lesions. With use of finetuned GoogleNet and AlexNet we attained results of 0.950 and 0.846 AUC on Seborrheic Keratosis and Melanoma respectively.
VIT University（VIT大学）；SSN College of Engineering（SSN工程学院）
Skin cancer is the most common of all cancers and each year million cases of skin cancer are treated. Treating and curing skin cancer is easy, if it is diagnosed and treated at an early stage. In this work we propose an automatic technique for skin lesion segmentation in dermoscopic images which helps in classifying the skin cancer types. The proposed method comprises of two major phases (1) preprocessing and (2) segmentation using semi-supervised learning algorithm. In the preprocessing phase noise are removed using filtering technique and in the segmentation phase skin lesions are segmented …
This report summarises our method and validation results for the ISIC Challenge 2018 - Skin Lesion Analysis Towards Melanoma Detection - Task 1: Lesion Segmentation. We present a two-stage method for lesion segmentation with optimised training method and ensemble post-process. Our method achieves state-of-the-art performance on lesion segmentation and we win the first place in ISIC 2018 task1.
We proposed a two stage framework with only one network to analyze skin lesion images, we firstly trained a convolutional network to classify these images, and cropped the import regions which the network has the maximum activation value. In the second stage, we retrained this CNN with the image regions extracted from stage one and output the final probabilities. The two stage framework achieved a mean AUC of 0.857 in ISIC-2017 skin lesion validation set and is 0.04 higher than that of the original inputs, 0.821.
University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Northwestern Polytechnical University（西北工业大学）
We recognize that the skin lesion diagnosis is an essential and challenging sub-task in Image classification, in which the Fisher vector (FV) encoding algorithm and deep convolutional neural network (DCNN) are two of the most successful techniques. Since the joint use of FV and DCNN has demonstrated proven success, the joint techniques could have discriminatory power on skin lesion diagnosis as well. To this hypothesis, we propose the aggregation algorithm for skin lesion diagnosis that utilize the residual network to extract the local features and the Fisher vector method to aggregate the loc…
CNR-ISASI（意大利国家研究委员会应用科学与智能系统研究所）；University of Salento（萨兰托大学）
This article presents a Deep CNN, based on the DenseNet architecture jointly with a highly discriminating learning methodology, in order to classify seven kinds of skin lesions: Melanoma, Melanocytic nevus, Basal cell carcinoma, Actinic keratosis / Bowen's disease, Benign keratosis, Dermatofibroma, Vascular lesion. In particular a 61 layers DenseNet, pre-trained on IMAGENET dataset, has been fine-tuned on ISIC 2018 Task 3 Challenge Dataset exploiting a Center Loss function.
McGill University（麦吉尔大学）；Universite de Montrea（蒙特利尔大学）；ETS Montreal（蒙特利尔高等工程学院）
In this paper, we study the problem of out-of-distribution detection in skin disease images. Publicly available medical datasets normally have a limited number of lesion classes (e.g. HAM10000 has 8 lesion classes). However, there exists a few thousands of clinically identified diseases. Hence, it is important if lesions not in the training data can be differentiated. Toward this goal, we propose DeepIF, a non-parametric Isolation Forest based approach combined with deep convolutional networks. We conduct comprehensive experiments to compare our DeepIF with three baseline models. Results demon…
Accurate segmentation of skin lesion from dermoscopic images is a crucial part of computer-aided diagnosis of melanoma. It is challenging due to the fact that dermoscopic images from different patients have non-negligible lesion variation, which causes difficulties in anatomical structure learning and consistent skin lesion delineation. In this paper, we propose a novel bi-directional dermoscopic feature learning (biDFL) framework to model the complex correlation between skin lesions and their informative context. By controlling feature information passing through two complementary directions,…
Northwestern Polytechnical University（西北工业大学）；University of Adelaide（阿德莱德大学）
Automated skin lesion segmentation and classification are two most essential and related tasks in the computer-aided diagnosis of skin cancer. Despite their prevalence, deep learning models are usually designed for only one task, ignoring the potential benefits in jointly performing both tasks. In this paper, we propose the mutual bootstrapping deep convolutional neural networks (MB-DCNN) model for simultaneous skin lesion segmentation and classification. This model consists of a coarse segmentation network (coarse-SN), a mask-guided classification network (mask-CN), and an enhanced segmentati…
Institute of High Performance Computing, A*STAR（新加坡科技研究局高性能计算研究所）；Institute for Infocomm Research, A*STAR（新加坡科技研究局资讯通信研究院）；National Skin Center, National Healthcare Group（国立皮肤中心，国立保健集团）
In this study, a multi-task deep neural network is proposed for skin lesion analysis. The proposed multi-task learning model solves different tasks (e.g., lesion segmentation and two independent binary lesion classifications) at the same time by exploiting commonalities and differences across tasks. This results in improved learning efficiency and potential prediction accuracy for the task-specific models, when compared to training the individual models separately. The proposed multi-task deep learning model is trained and evaluated on the dermoscopic image sets from the International Skin Ima…
Unsupervised Skin Lesion Segmentation via Structural Entropy Minimization on Multi-Scale Superpixel Graphs
Beihang University（北京航空航天大学）；Zhongguancun Laboratory（中关村实验室）；Salesforce AI Research（赛富时人工智能研究院）；Didi Chuxing（滴滴出行）；University of Illinois Chicago（伊利诺伊大学芝加哥分校）；Lehigh University（理海大学）
Indian Institute of Technology, Kharagpur（印度理工学院卡哈拉格普尔分校）；Nanyang Technological University（南洋理工大学）
This paper summarizes the method used in our submission to Task 1 of the International Skin Imaging Collaboration's (ISIC) Skin Lesion Analysis Towards Melanoma Detection challenge held in 2018. We used a fully automated method to accurately segment lesion boundaries from dermoscopic images. A U-net deep learning network is trained on publicly available data from ISIC. We introduce the use of intensity, color, and texture enhancement operations as pre-processing steps and morphological operations and contour identification as post-processing steps.
This report describes our submission to the ISIC 2017 Challenge in Skin Lesion Analysis Towards Melanoma Detection. We have participated in the Part 3: Lesion Classification with a system for automatic diagnosis of nevus, melanoma and seborrheic keratosis. Our approach aims to incorporate the expert knowledge of dermatologists into the well known framework of Convolutional Neural Networks (CNN), which have shown impressive performance in many visual recognition tasks. In particular, we have designed several networks providing lesion area identification, lesion segmentation into structural patt…
Samsung Advanced Institute of Health Sciences and Technology（三星健康科学与技术高级研究院）；Sungkyunkwan University（成均馆大学）；Samsung Medical Center（三星医疗中心）
As skin cancer is one of the most frequent cancers globally, accurate, non-invasive dermoscopy-based diagnosis becomes essential and promising. A task of the Part 3 of the ISIC Skin Image Analysis Challenge at MICCAI 2018 is to predict seven disease classes with skin lesion images, including melanoma (MEL), melanocytic nevus (NV), basal cell carcinoma (BCC), actinic keratosis / Bowen's disease (intraepithelial carcinoma) (AKIEC), benign keratosis (solar lentigo / seborrheic keratosis / lichen planus-like keratosis) (BKL), dermatofibroma (DF) and vascular lesion (VASC) as defined by the Interna…
Computer Vision Institute, College of Computer Science and Software Engineering, Shenzhen University（深圳大学计算机与软件学院计算机视觉研究所）
Skin lesion is a severe disease in world-wide extent. Early detection of melanoma in dermoscopy images significantly increases the survival rate. However, the accurate recognition of melanoma is extremely challenging due to the following reasons, e.g. low contrast between lesions and skin, visual similarity between melanoma and non-melanoma lesions, etc. Hence, reliable automatic detection of skin tumors is very useful to increase the accuracy and efficiency of pathologists. International Skin Imaging Collaboration (ISIC) is a challenge focusing on the automatic analysis of skin lesion. In thi…
In this report, we introduce the outline of our system in Task 3: Disease Classification of ISIC 2018: Skin Lesion Analysis Towards Melanoma Detection. We fine-tuned multiple pre-trained neural network models based on Squeeze-and-Excitation Networks (SENet) which achieved state-of-the-art results in the field of image recognition. In addition, we used the mean teachers as a semi-supervised learning framework and introduced some specially designed data augmentation strategies for skin lesion analysis. We confirmed our data augmentation strategy improved classification performance and demonstrat…
Indian Institute of Technology, Varanasi（瓦拉纳西印度理工学院）；Nanyang Technological University（南洋理工大学）
This work summarizes our submission for the Task 3: Disease Classification of ISIC 2018 challenge in Skin Lesion Analysis Towards Melanoma Detection. We use a novel deep neural network (DNN) ensemble architecture introduced by us that can effectively classify skin lesions by using data-augmentation and bagging to address paucity of data and prevent over-fitting. The ensemble is composed of two DNN architectures: Inception-v4 and Inception-Resnet-v2. The DNN architectures are combined in to an ensemble by using a $1\times1$ convolution for fusion in a meta-learning layer.
