Super-resolution plays an essential role in medical imaging because it provides an alternative way to achieve high spatial resolutions and image quality with no extra acquisition costs. In the past few decades, the rapid development of deep neural networks has promoted super-resolution performance with novel network architectures, loss functions and evaluation metrics. Specifically, vision transformers dominate a broad range of computer vision tasks, but challenges still exist when applying them to low-level medical image processing tasks. This paper proposes an efficient vision transformer with residual dense connections and local feature fusion to achieve efficient single-image super-resolution (SISR) of medical modalities. Moreover, we implement a general-purpose perceptual loss with manual control for image quality improvements of desired aspects by incorporating prior knowledge of medical image segmentation. Compared with state-of-the-art methods on four public medical image datasets, the proposed method achieves the best PSNR scores of 6 modalities among seven modalities. It leads to an average improvement of $+0.09$ dB PSNR with only 38\% parameters of SwinIR. On the other hand, the segmentation-based perceptual loss increases $+0.14$ dB PSNR on average for SOTA methods, including CNNs and vision transformers. Additionally, we conduct comprehensive ablation studies to discuss potential factors for the superior performance of vision transformers over CNNs and the impacts of network and loss function components. The code will be released on GitHub with the paper published.
Indian Institute of Technology Bombay（印度理工学院孟买分校）；Whirlpool（惠而浦公司）
Capturing high-resolution magnetic resonance (MR) images is a time consuming process, which makes it unsuitable for medical emergencies and pediatric patients. Low-resolution MR imaging, by contrast, is faster than its high-resolution counterpart, but it compromises on fine details necessary for a more precise diagnosis. Super-resolution (SR), when applied to low-resolution MR images, can help increase their utility by synthetically generating high-resolution images with little additional time. In this paper, we present a SR technique for MR images that is based on generative adversarial netwo…
Perceptually Regularized Diffusion Model for Image Super-Resolution
University of North Carolina（北卡罗来纳大学）；Texas Tech University（德克萨斯理工大学）；Case Western Reserve University（凯斯西储大学）；University of Houston（休斯顿大学）；University of Kentucky（肯塔基大学）
Predicting diagnoses from Electronic Health Records (EHRs) is an important medical application of multi-label learning. We propose a convolutional residual model for multi-label classification from doctor notes in EHR data. A given patient may have multiple diagnoses, and therefore multi-label learning is required. We employ a Convolutional Neural Network (CNN) to encode plain text into a fixed-length sentence embedding vector. Since diagnoses are typically correlated, a deep residual network is employed on top of the CNN encoder, to capture label (diagnosis) dependencies and incorporate infor…
Télécom Paris, Institut Polytechnique de Paris（巴黎理工学院巴黎电信学院）；CNRS（法国国家科学研究中心）
In medical imaging, most of the image registration methods implicitly assume a one-to-one correspondence between the source and target images (i.e., diffeomorphism). However, this is not necessarily the case when dealing with pathological medical images (e.g., presence of a tumor, lesion, etc.). To cope with this issue, the Metamorphosis model has been proposed. It modifies both the shape and the appearance of an image to deal with the geometrical and topological differences. However, the high computational time and load have hampered its applications so far. Here, we propose a deep residual l…
Birla Institute of Technology Science Pilani（比尔拉理工学院皮拉尼分校）
In this work, we present Eformer - Edge enhancement based transformer, a novel architecture that builds an encoder-decoder network using transformer blocks for medical image denoising. Non-overlapping window-based self-attention is used in the transformer block that reduces computational requirements. This work further incorporates learnable Sobel-Feldman operators to enhance edges in the image and propose an effective way to concatenate them in the intermediate layers of our architecture. The experimental analysis is conducted by comparing deterministic learning and residual learning for the …
One-Step Residual Shifting Diffusion for Image Super-Resolution via Distillation
Kandinsky Lab（坎迪斯基实验室）；Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）；Luzin Research Center（卢津研究所）；Moscow Independent Research Institute of Artificial Intelligence（莫斯科独立人工智能研究 institute）；Applied AI Institute（应用人工智能研究所）
Chinese Academy of Sciences（中国科学院）；University of Chinese Academy of Sciences（中国科学院大学）；Walton Institute for Information and Communication Systems Science（沃尔顿信息与通信系统科学研究所）；Waterford Institute of Technology（沃特福德理工学院）；University of Johannesburg（约翰内斯堡大学）；University of Sindh（信德大学）；Sungkyunkwan University（成均馆大学）
Deep learning based single image super resolution (SISR) algorithms has revolutionized the overall diagnosis framework by continually improving the architectural components and training strategies associated with convolutional neural networks (CNN) on low-resolution images. However, existing work lacks in two ways: i) the SR output produced exhibits poor texture details, and often produce blurred edges, ii) most of the models have been developed for a single modality, hence, require modification to adapt to a new one. This work addresses (i) by proposing generative adversarial network (GAN) wi…
The recent advances in deep learning indicate significant progress in the field of single image super-resolution. With the advent of these techniques, high-resolution image with high peak signal to noise ratio (PSNR) and excellent perceptual quality can be reconstructed. The major challenges associated with existing deep convolutional neural networks are their computational complexity and time; the increasing depth of the networks, often result in high space complexity. To alleviate these issues, we developed an innovative shallow residual feature representative network (SRFRN) that uses a bic…
West Virginia University（西弗吉尼亚大学）；Case Western Reserve University（凯斯西储大学）
Image demosaicing and super-resolution are two important tasks in color imaging pipeline. So far they have been mostly independently studied in the open literature of deep learning; little is known about the potential benefit of formulating a joint demosaicing and super-resolution (JDSR) problem. In this paper, we propose an end-to-end optimization solution to the JDSR problem and demonstrate its practical significance in computational imaging. Our technical contributions are mainly two-fold. On network design, we have developed a Residual-Dense Squeeze-and-Excitation Networks (RDSEN) supporte…
In this paper, a novel Full Reference method is proposed for image quality assessment, using the combination of two separate metrics to measure the perceptually distinct impact of detail losses and of spurious details. To this purpose, the gradient of the impaired image is locally decomposed as a predicted version of the original gradient, plus a gradient residual. It is assumed that the detail attenuation identifies the detail loss, whereas the gradient residuals describe the spurious details. It turns out that the perceptual impact of detail losses is roughly linear with the loss of the posi…
We present a deep residual network-based generative model for single image super-resolution (SISR) of underwater imagery for use by autonomous underwater robots. We also provide an adversarial training pipeline for learning SISR from paired data. In order to supervise the training, we formulate an objective function that evaluates the \textit{perceptual quality} of an image based on its global content, color, and local style information. Additionally, we present USR-248, a large-scale dataset of three sets of underwater images of 'high' (640x480) and 'low' (80x60, 160x120, and 320x240) spatial…
The HongKong Polytechnic University（香港理工大学）；OPPO Research（OPPO研究院）
Single image super-resolution (SISR) with generative adversarial networks (GAN) has recently attracted increasing attention due to its potentials to generate rich details. However, the training of GAN is unstable, and it often introduces many perceptually unpleasant artifacts along with the generated details. In this paper, we demonstrate that it is possible to train a GAN-based SISR model which can stably generate perceptually realistic details while inhibiting visual artifacts. Based on the observation that the local statistics (e.g., residual variance) of artifact areas are often different …
Osaka Electro-Communication University（大阪电气通信大学）；Ritsumeikan University（立命馆大学）；Shiga University of Medical Science（滋贺医科大学）
Deep learning techniques have led to state-of-the-art image super resolution with natural images. Normally, pairs of high-resolution and low-resolution images are used to train the deep learning models. These techniques have also been applied to medical image super-resolution. The characteristics of medical images differ significantly from natural images in several ways. First, it is difficult to obtain high-resolution images for training in real clinical applications due to the limitations of imaging systems and clinical requirements. Second, other modal high-resolution images are available (…
Technical University of Munich（慕尼黑工业大学）；University of Zurich（苏黎世大学）；Southern University of Science and Technology（南方科技大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Quantifying the perceptual similarity of two images is a long-standing problem in low-level computer vision. The natural image domain commonly relies on supervised learning, e.g., a pre-trained VGG, to obtain a latent representation. However, due to domain shift, pre-trained models from the natural image domain might not apply to other image domains, such as medical imaging. Notably, in medical imaging, evaluating the perceptual similarity is exclusively performed by specialists trained extensively in diverse medical fields. Thus, medical imaging remains devoid of task-specific, objective perc…
The University of Hong Kong（香港大学）；Huawei Noah’s Ark Lab（华为诺亚方舟实验室）
Plenoptic cameras usually sacrifice the spatial resolution of their SAIs to acquire geometry information from different viewpoints. Several methods have been proposed to mitigate such spatio-angular trade-off, but seldom make use of the structural properties of the light field (LF) data efficiently. In this paper, we propose a novel high-order residual network to learn the geometric features hierarchically from the LF for reconstruction. An important component in the proposed network is the high-order residual block (HRB), which learns the local geometric features by considering the informatio…
Diffusion probabilistic models have recently achieved remarkable success in generating high quality image and video data. In this work, we build on this class of generative models and introduce a method for lossy compression of high resolution images. The resulting codec, which we call DIffuson-based Residual Augmentation Codec (DIRAC), is the first neural codec to allow smooth traversal of the rate-distortion-perception tradeoff at test time, while obtaining competitive performance with GAN-based methods in perceptual quality. Furthermore, while sampling from diffusion probabilistic models is…
Xiamen University（厦门大学）；Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）
Image quality measurement is a critical problem for image super-resolution (SR) algorithms. Usually, they are evaluated by some well-known objective metrics, e.g., PSNR and SSIM, but these indices cannot provide suitable results in accordance with the perception of human being. Recently, a more reasonable perception measurement has been proposed in [1], which is also adopted by the PIRM-SR 2018 challenge. In this paper, motivated by [1], we aim to generate a high-quality SR result which balances between the two indices, i.e., the perception index and root-mean-square error (RMSE). To do so, we…
Graduate School at Shenzhen, Tsinghua University（清华大学深圳研究生院）；Computer Science and Engineering, University of South Carolina（南卡罗来纳大学计算机科学与工程系）
The implementation of medical AI has always been a problem. The effect of traditional perceptual AI algorithm in medical image processing needs to be improved. Here we propose a method of knowledge AI, which is a combination of perceptual AI and clinical knowledge and experience. Based on this method, the geometric information mining of medical images can represent the experience and information and evaluate the quality of medical images.
University of Electronic Science and Technology of China（电子科技大学）；Nokia Bell Labs（诺基亚贝尔实验室）；Nanyang Technological University（南洋理工大学）；University of Macau（澳门大学）；Nanjing Institute of Technology（南京工程学院）
In this paper, we propose a novel approach to the rank minimization problem, termed rank residual constraint (RRC) model. Different from existing low-rank based approaches, such as the well-known nuclear norm minimization (NNM) and the weighted nuclear norm minimization (WNNM), which estimate the underlying low-rank matrix directly from the corrupted observations, we progressively approximate the underlying low-rank matrix via minimizing the rank residual. Through integrating the image nonlocal self-similarity (NSS) prior with the proposed RRC model, we apply it to image restoration tasks, inc…
University of Cambridge（剑桥大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Single image super-resolution (SISR) is of great importance as a low-level computer vision task. The fast development of Generative Adversarial Network (GAN) based deep learning architectures realises an efficient and effective SISR to boost the spatial resolution of natural images captured by digital cameras. However, the SISR for medical images is still a very challenging problem. This is due to (1) compared to natural images, in general, medical images have lower signal to noise ratios, (2) GAN based models pre-trained on natural images may synthesise unrealistic patterns in medical images …
The shapes and morphology of the organs and tissues are important prior knowledge in medical imaging recognition and segmentation. The morphological operation is a well-known method for morphological feature extraction. As the morphological operation is performed well in hand-crafted image segmentation techniques, it is also promising to design an approach to approximate morphological operation in the convolutional networks. However, using the traditional convolutional neural network as a black-box is usually hard to specify the morphological operation action. Here, we introduced a 3D morpholo…
Automated and accurate 3D medical image segmentation plays an essential role in assisting medical professionals to evaluate disease progresses and make fast therapeutic schedules. Although deep convolutional neural networks (DCNNs) have widely applied to this task, the accuracy of these models still need to be further improved mainly due to their limited ability to 3D context perception. In this paper, we propose the 3D context residual network (ConResNet) for the accurate segmentation of 3D medical images. This model consists of an encoder, a segmentation decoder, and a context residual decod…
OpenMined；Manifold Computing Group（曼尼福德计算集团）；Ford R&A（福特研发部门）；Harvard University（哈佛大学）；Indian Institute of Technology Jodhpur（印度理工学院焦特布尔分校）；University of Oxford（牛津大学）
In this paper we measure the effectiveness of $ε$-Differential Privacy (DP) when applied to medical imaging. We compare two robust differential privacy mechanisms: Local-DP and DP-SGD and benchmark their performance when analyzing medical imagery records. We analyze the trade-off between the model's accuracy and the level of privacy it guarantees, and also take a closer look to evaluate how useful these theoretical privacy guarantees actually prove to be in the real world medical setting.
Location information is proven to benefit the deep learning models on capturing the manifold structure of target objects, and accordingly boosts the accuracy of medical image segmentation. However, most existing methods encode the location information in an implicit way, e.g. the distance transform maps, which describe the relative distance from each pixel to the contour boundary, for the network to learn. These implicit approaches do not fully exploit the position information (i.e. absolute location) of targets. In this paper, we propose a novel loss function, namely residual moment (RM) loss…
Bilkent University（比尔肯特大学）；National Magnetic Resonance Research Center (UMRAM)（国家磁共振研究中心（UMRAM））；Sabuncu Brain Research Center（萨本库脑研究中心）
Generative adversarial models with convolutional neural network (CNN) backbones have recently been established as state-of-the-art in numerous medical image synthesis tasks. However, CNNs are designed to perform local processing with compact filters, and this inductive bias compromises learning of contextual features. Here, we propose a novel generative adversarial approach for medical image synthesis, ResViT, that leverages the contextual sensitivity of vision transformers along with the precision of convolution operators and realism of adversarial learning.} ResViT's generator employs a cent…
A Residual Multi-task Network for Joint Classification and Regression in Medical Imaging
School of Computer Science and Technology, University of Chinese Academy of Sciences（中国科学院大学计算机科学与技术学院）；College of Surveying and GeoInformatics, Tongji University（同济大学测绘与地理信息学院）；School of Computer Science, Shaanxi Normal University（陕西师范大学计算机学院）
Deep Convolutional Neural Networks (CNNs) i.e. Residual Networks (ResNets) have been used successfully for many computer vision tasks, but are difficult to scale to 3D volumetric medical data. Memory is increasingly often the bottleneck when training 3D Convolutional Neural Networks (CNNs). Recently, invertible neural networks have been applied to significantly reduce activation memory footprint when training neural networks with backpropagation thanks to the invertible functions that allow retrieving its input from its output without storing intermediate activations in memory to perform the b…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Center for Devices and Radiological Health, Food and Drug Administration（美国食品药品监督管理局设备与放射健康中心）
In recent years, generative adversarial networks (GANs) have gained tremendous popularity for potential applications in medical imaging, such as medical image synthesis, restoration, reconstruction, translation, as well as objective image quality assessment. Despite the impressive progress in generating high-resolution, perceptually realistic images, it is not clear if modern GANs reliably learn the statistics that are meaningful to a downstream medical imaging application. In this work, the ability of a state-of-the-art GAN to learn the statistics of canonical stochastic image models (SIMs) t…
Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET
Department of Artificial Intelligence, Hanyang University, Seoul, South Korea（人工智能系，翰阳大学，首尔，韩国）；Department of Electronic Engineering, Hanyang University, Seoul, South Korea（电子工程系，翰阳大学，首尔，韩国）；Division of Computer Engineering, Hankuk University of Foreign Studies, Yongin, South Korea（计算机工程系，韩国外语大学， Yongin，韩国）；Division of AI Data Convergence, Hankuk University of Foreign Studies, Yongin, South Korea（AI数据融合系，韩国外语大学， Yongin，韩国）；Division of Language & AI, Hankuk University of Foreign Studies, Seoul, South Korea（语言与AI系，韩国外语大学，首尔，韩国）
COMSATS University Islamabad（伊斯兰堡COMSATS大学）；Umeå University（于默奥大学）
U-Net is a widely adopted neural network in the domain of medical image segmentation. Despite its quick embracement by the medical imaging community, its performance suffers on complicated datasets. The problem can be ascribed to its simple feature extracting blocks: encoder/decoder, and the semantic gap between encoder and decoder. Variants of U-Net (such as R2U-Net) have been proposed to address the problem of simple feature extracting blocks by making the network deeper, but it does not deal with the semantic gap problem. On the other hand, another variant UNET++ deals with the semantic gap…
The Hong Kong Polytechnic University（香港理工大学）；University of Oxford（牛津大学）
Automatic medical image segmentation based on Computed Tomography (CT) has been widely applied for computer-aided surgery as a prerequisite. With the development of deep learning technologies, deep convolutional neural networks (DCNNs) have shown robust performance in automated semantic segmentation of medical images. However, semantic segmentation algorithms based on DCNNs still meet the challenges of feature loss between encoder and decoder, multi-scale object, restricted field of view of filters, and lack of medical image data. This paper proposes a novel algorithm for automated vertebrae s…
Linear Algebraic Approaches to Neuroimaging Data Compression: A Comparative Analysis of Matrix and Tensor Decomposition Methods for High-Dimensional Medical Images
Indian Institute of Information Technology Allahabad（印度阿拉哈巴德信息技术学院）
In this work, we propose a two-stage autoencoder based compressor-decompressor framework for compressing malaria RBC cell image patches. We know that the medical images used for disease diagnosis are around multiple gigabytes size, which is quite huge. The proposed residual-based dual autoencoder network is trained to extract the unique features which are then used to reconstruct the original image through the decompressor module. The two latent space representations (first for the original image and second for the residual image) are used to rebuild the final original image. Color-SSIM has be…
The University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Rice University（莱斯大学）；University of California San Diego（加州大学圣地亚哥分校）
Although generative adversarial networks (GANs) have shown promise in medical imaging, they have four main limitations that impeded their utility: computational cost, data requirements, reliable evaluation measures, and training complexity. Our work investigates each of these obstacles in a novel application of StyleGAN2-ADA to high-resolution medical imaging datasets. Our dataset is comprised of liver-containing axial slices from non-contrast and contrast-enhanced computed tomography (CT) scans. Additionally, we utilized four public datasets composed of various imaging modalities. We trained …
