Due to numerous hardware shortcomings, medical image acquisition devices are susceptible to producing low-quality (i.e., low contrast, inappropriate brightness, noisy, etc.) images. Regrettably, perceptually degraded images directly impact the diagnosis process and make the decision-making manoeuvre of medical practitioners notably complicated. This study proposes to enhance such low-quality images by incorporating end-to-end learning strategies for accelerating medical image analysis tasks. To the best concern, this is the first work in medical imaging which comprehensively tackles perceptual enhancement, including contrast correction, luminance correction, denoising, etc., with a fully convolutional deep network. The proposed network leverages residual blocks and a residual gating mechanism for diminishing visual artefacts and is guided by a multi-term objective function to perceive the perceptually plausible enhanced images. The practicability of the deep medical image enhancement method has been extensively investigated with sophisticated experiments. The experimental outcomes illustrate that the proposed method could outperform the existing enhancement methods for different medical image modalities by 5.00 to 7.00 dB in peak signal-to-noise ratio (PSNR) metrics and 4.00 to 6.00 in DeltaE metrics. Additionally, the proposed method can drastically improve the medical image analysis tasks' performance and reveal the potentiality of such an enhancement method in real-world applications. Code Available: https://github.com/sharif-apu/DPE_JBHI
Technical University of Munich（慕尼黑工业大学）；University of Zurich（苏黎世大学）；Southern University of Science and Technology（南方科技大学）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Quantifying the perceptual similarity of two images is a long-standing problem in low-level computer vision. The natural image domain commonly relies on supervised learning, e.g., a pre-trained VGG, to obtain a latent representation. However, due to domain shift, pre-trained models from the natural image domain might not apply to other image domains, such as medical imaging. Notably, in medical imaging, evaluating the perceptual similarity is exclusively performed by specialists trained extensively in diverse medical fields. Thus, medical imaging remains devoid of task-specific, objective perc…
Graduate School at Shenzhen, Tsinghua University（清华大学深圳研究生院）；Computer Science and Engineering, University of South Carolina（南卡罗来纳大学计算机科学与工程系）
The implementation of medical AI has always been a problem. The effect of traditional perceptual AI algorithm in medical image processing needs to be improved. Here we propose a method of knowledge AI, which is a combination of perceptual AI and clinical knowledge and experience. Based on this method, the geometric information mining of medical images can represent the experience and information and evaluate the quality of medical images.
Philips Research（飞利浦研究院）；Skolkovo Institute of Science and Technology（斯科尔科沃科学技术研究院）；Goethe University Frankfurt（法兰克福歌德大学）
Anomaly detection is the problem of recognizing abnormal inputs based on the seen examples of normal data. Despite recent advances of deep learning in recognizing image anomalies, these methods still prove incapable of handling complex medical images, such as barely visible abnormalities in chest X-rays and metastases in lymph nodes. To address this problem, we introduce a new powerful method of image anomaly detection. It relies on the classical autoencoder approach with a re-designed training pipeline to handle high-resolution, complex images and a robust way of computing an image abnormalit…
Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET
Department of Artificial Intelligence, Hanyang University, Seoul, South Korea（人工智能系，翰阳大学，首尔，韩国）；Department of Electronic Engineering, Hanyang University, Seoul, South Korea（电子工程系，翰阳大学，首尔，韩国）；Division of Computer Engineering, Hankuk University of Foreign Studies, Yongin, South Korea（计算机工程系，韩国外语大学， Yongin，韩国）；Division of AI Data Convergence, Hankuk University of Foreign Studies, Yongin, South Korea（AI数据融合系，韩国外语大学， Yongin，韩国）；Division of Language & AI, Hankuk University of Foreign Studies, Seoul, South Korea（语言与AI系，韩国外语大学，首尔，韩国）
Linear Algebraic Approaches to Neuroimaging Data Compression: A Comparative Analysis of Matrix and Tensor Decomposition Methods for High-Dimensional Medical Images
University of Cambridge（剑桥大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Single image super-resolution (SISR) is of great importance as a low-level computer vision task. The fast development of Generative Adversarial Network (GAN) based deep learning architectures realises an efficient and effective SISR to boost the spatial resolution of natural images captured by digital cameras. However, the SISR for medical images is still a very challenging problem. This is due to (1) compared to natural images, in general, medical images have lower signal to noise ratios, (2) GAN based models pre-trained on natural images may synthesise unrealistic patterns in medical images …
Dublin City University（都柏林城市大学）；University College Dublin（都柏林大学学院）
Over the years, the paradigm of medical image analysis has shifted from manual expertise to automated systems, often using deep learning (DL) systems. The performance of deep learning algorithms is highly dependent on data quality. Particularly for the medical domain, it is an important aspect as medical data is very sensitive to quality and poor quality can lead to misdiagnosis. To improve the diagnostic performance, research has been done both in complex DL architectures and in improving data quality using dataset dependent static hyperparameters. However, the performance is still constraine…
Institute for Parallel and Distributed Systems, University of Stuttgart（斯图加特大学并行与分布式系统研究所）
Image registration is a fundamental task for medical imaging. Resampling of the intensity values is required during registration and better spatial resolution with finer and sharper structures can improve the resampling performance and hence the registration accuracy. Super-resolution (SR) is an algorithmic technique targeting at spatial resolution enhancement which can achieve an image resolution beyond the hardware limitation. In this work, we consider SR as a preprocessing technique and present a CNN-based resolution enhancement module (REM) which can be easily plugged into the registration…
In this work we examine the performance enhancement in classification of medical imaging data when image features are combined with associated non-image data. We compare the performance of eight state-of-the-art deep neural networks in classification tasks when using only image features, compared to when these are combined with patient metadata. We utilise transfer learning with networks pretrained on ImageNet used directly as feature extractors and fine tuned on the target domain. Our experiments show that performance can be significantly enhanced with the inclusion of metadata and use interp…
Numerous factors could lead to partial deteriorations of medical images. For example, metallic implants will lead to localized perturbations in MRI scans. This will affect further post-processing tasks such as attenuation correction in PET/MRI or radiation therapy planning. In this work, we propose the inpainting of medical images via Generative Adversarial Networks (GANs). The proposed framework incorporates two patch-based discriminator networks with additional style and perceptual losses for the inpainting of missing information in realistically detailed and contextually consistent manner. …
Joint Medical Image Enhancement and Segmentation with Diffusion-based Symbiotic Information Interaction
Shenzhen Research Institute, The Chinese University of Hong Kong（香港中文大学深圳研究院）；University of Science and Technology of China（中国科学技术大学）；Imperial Global Singapore, Imperial College London（伦敦帝国学院新加坡分校）
University of Electronic Science and Technology of China（电子科技大学）；Sichuan University（四川大学）
Deep learning has achieved notable performance in the denoising task of low-quality medical images and the detection task of lesions, respectively. However, existing low-quality medical image denoising approaches are disconnected from the detection task of lesions. Intuitively, the quality of denoised images will influence the lesion detection accuracy that in turn can be used to affect the denoising performance. To this end, we propose a play-and-plug medical image denoising framework, namely Lesion-Inspired Denoising Network (LIDnet), to collaboratively improve both denoising performance and…
Enhancement of human vision to get an insight to information content is of vital importance. The traditional histogram equalization methods have been suffering from amplified contrast with the addition of artifacts and a surprising unnatural visibility of the processed images. In order to overcome these drawbacks, this paper proposes interative, mean, and multi-threshold selection criterion with plateau limits, which consist of histogram segmentation, clipping and transformation modules. The histogram partition consists of multiple thresholding processes that divide the histogram into two part…
CENet: Context Enhancement Network for Medical Image Segmentation
Faculty of Informatics and Data Science, University of Regensburg（信息学院与数据科学学院，雷根施塔特大学）；Department of Industrial and Systems Engineering, Tarbiat Modares University（工业与系统工程系，塔里克特莫达res大学）；Department of Radiology & Department of Medicine, University of British Columbia（放射科与医学系，不列颠哥伦比亚大学）；Fraunhofer Institute for Digital Medicine MEVIS（数字医学研究所MEVIS）
CLADE: Cycle Loss Augmented Degradation Enhancement for Unpaired Super-Resolution of Anisotropic Medical Images
University College London（伦敦大学学院）；Institute of Cardiovascular Science（心血管科学研究所）；Centre for Medical Imaging（医学影像中心）；Frimley Health NHS Trust（弗林利健康 NHS 信托基金）；UCL NHS Trust（伦敦大学学院 NHS 信托基金）
The University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Rice University（莱斯大学）；University of California San Diego（加州大学圣地亚哥分校）
Although generative adversarial networks (GANs) have shown promise in medical imaging, they have four main limitations that impeded their utility: computational cost, data requirements, reliable evaluation measures, and training complexity. Our work investigates each of these obstacles in a novel application of StyleGAN2-ADA to high-resolution medical imaging datasets. Our dataset is comprised of liver-containing axial slices from non-contrast and contrast-enhanced computed tomography (CT) scans. Additionally, we utilized four public datasets composed of various imaging modalities. We trained …
MRI (Magnetic Resonance Imaging) is a technique used to analyze and diagnose the problem defined by images like cancer or tumor in a brain. Physicians require good contrast images for better treatment purpose as it contains maximum information of the disease. MRI images are low contrast images which make diagnoses difficult; hence better localization of image pixels is required. Histogram Equalization techniques help to enhance the image so that it gives an improved visual quality and a well defined problem. The contrast and brightness is enhanced in such a way that it does not lose its origin…
University of Stuttgart（斯图加特大学）；University of Tübingen（蒂宾根大学）；King’s College London（伦敦国王学院）
Image-to-image translation is a new field in computer vision with multiple potential applications in the medical domain. However, for supervised image translation frameworks, co-registered datasets, paired in a pixel-wise sense, are required. This is often difficult to acquire in realistic medical scenarios. On the other hand, unsupervised translation frameworks often result in blurred translated images with unrealistic details. In this work, we propose a new unsupervised translation framework which is titled Cycle-MedGAN. The proposed framework utilizes new non-adversarial cycle losses which …
Low-Level Dataset Distillation for Medical Image Enhancement
School of Cyber Science and Engineering, Sichuan University（四川大学计算机科学与工程学院）；The Chinese University of Hong Kong（香港中文大学）；Agency for Science, Technology and Research (A*STAR)（科技研究局）
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Shenzhen University（深圳大学）；Renmin University of China（中国人民大学）；Central South University（中南大学）
Alzheimer's disease is characterized by alterations of the brain's structural and functional connectivity during its progressive degenerative processes. Existing auxiliary diagnostic methods have accomplished the classification task, but few of them can accurately evaluate the changing characteristics of brain connectivity. In this work, a prior guided adversarial representation learning and hypergraph perceptual network (PGARL-HPN) is proposed to predict abnormal brain connections using triple-modality medical images. Concretely, a prior distribution from the anatomical knowledge is estimated…
Slovak University of Technology（斯洛伐克理工大学）；Johannes Kepler University（约翰内斯·开普勒大学）
In many practical applications, deep neural networks have been typically deployed to operate as a black box predictor. Despite the high amount of work on interpretability and high demand on the reliability of these systems, they typically still have to include a human actor in the loop, to validate the decisions and handle unpredictable failures and unexpected corner cases. This is true in particular for failure-critical application domains, such as medical diagnosis. We present a novel approach to explain and support an interpretation of the decision-making process to a human expert operating…
In this paper, we introduce a novel deep neural network suitable for multi-scale analysis and propose efficient model-agnostic methods that help the network extract information from high-frequency domains to reconstruct clearer images. Our model can be applied to multi-scale image enhancement problems including denoising, deblurring and single image super-resolution. Experiments on SIDD, Flickr2K, DIV2K, and REDS datasets show that our method achieves state-of-the-art performance on each task. Furthermore, we show that our model can overcome the over-smoothing problem commonly observed in exis…
Distributed Deep Learning for Medical Image Denoising with Data Obfuscation
Computer Engineering Department, King Fahd University of Petroleum and Minerals（国王法赫德石油与矿物大学计算机工程系）；King Fahd University of Petroleum and Minerals（国王法赫德石油与矿物大学）；SDAIA-KFUPM Joint Research Center for Artificial Intelligence（SDAIA-KFUPM人工智能联合研究中心）
Hangzhou Innovation Institute, Beihang University（北京航空航天大学杭州创新研究院）；Department of Computer Science, University of Oxford（牛津大学计算机科学系）
The past few years have witnessed fast development in video quality enhancement via deep learning. Existing methods mainly focus on enhancing the objective quality of compressed video while ignoring its perceptual quality. In this paper, we focus on enhancing the perceptual quality of compressed video. Our main observation is that enhancing the perceptual quality mostly relies on recovering high-frequency sub-bands in wavelet domain. Accordingly, we propose a novel generative adversarial network (GAN) based on multi-level wavelet packet transform (WPT) to enhance the perceptual quality of comp…
Features obtained from object recognition CNNs have been widely used for measuring perceptual similarities between images. Such differentiable metrics can be used as perceptual learning losses to train image enhancement models. However, the choice of the distance function between input and target features may have a consequential impact on the performance of the trained model. While using the norm of the difference between extracted features leads to limited hallucination of details, measuring the distance between distributions of features may generate more textures; yet also more unrealistic …
Xidian University（西安电子科技大学）；Universitat Autònoma de Barcelona（巴塞罗那自治大学）；Northwestern Polytechnical University（西北工业大学）
In this paper, we propose a deformable convolution-based generative adversarial network (DCNGAN) for perceptual quality enhancement of compressed videos. DCNGAN is also adaptive to the quantization parameters (QPs). Compared with optical flows, deformable convolutions are more effective and efficient to align frames. Deformable convolutions can operate on multiple frames, thus leveraging more temporal information, which is beneficial for enhancing the perceptual quality of compressed videos. Instead of aligning frames in a pairwise manner, the deformable convolution can process multiple frames…
University of Cambridge（剑桥大学）；Imperial College London（帝国理工学院）；Royal Brompton Hospital（皇家布朗普顿医院）
Super-resolution plays an essential role in medical imaging because it provides an alternative way to achieve high spatial resolutions and image quality with no extra acquisition costs. In the past few decades, the rapid development of deep neural networks has promoted super-resolution performance with novel network architectures, loss functions and evaluation metrics. Specifically, vision transformers dominate a broad range of computer vision tasks, but challenges still exist when applying them to low-level medical image processing tasks. This paper proposes an efficient vision transformer wi…
Xidian University（西安电子科技大学）；Universitat Autònoma de Barcelona（巴塞罗那自治大学）；BBC Research & Development（英国广播公司研发部）；Northwestern Polytechnical University（西北工业大学）
In this paper we propose a generative adversarial network (GAN) framework to enhance the perceptual quality of compressed videos. Our framework includes attention and adaptation to different quantization parameters (QPs) in a single model. The attention module exploits global receptive fields that can capture and align long-range correlations between consecutive frames, which can be beneficial for enhancing perceptual quality of videos. The frame to be enhanced is fed into the deep network together with its neighboring frames, and in the first stage features at different depths are extracted. …
Image based Deep Feature Quality Metrics (DFQMs) have been shown to better correlate with subjective perceptual scores over traditional metrics. The fundamental focus of these DFQMs is to exploit internal representations from a large scale classification network as the metric feature space. Previously, no attention has been given to the problem of identifying which layers are most perceptually relevant. In this paper we present a new method for selecting perceptually relevant layers from such a network, based on a neuroscience interpretation of layer behaviour. The selected layers are treated …
Recently, many video enhancement methods have been proposed to improve video quality from different aspects such as color, brightness, contrast, and stability. Therefore, how to evaluate the quality of the enhanced video in a way consistent with human visual perception is an important research topic. However, most video quality assessment methods mainly calculate video quality by estimating the distortion degrees of videos from an overall perspective. Few researchers have specifically proposed a video quality assessment method for video enhancement, and there is also no comprehensive video qua…
Birla Institute of Technology Science Pilani（比尔拉理工学院皮拉尼分校）
In this work, we present Eformer - Edge enhancement based transformer, a novel architecture that builds an encoder-decoder network using transformer blocks for medical image denoising. Non-overlapping window-based self-attention is used in the transformer block that reduces computational requirements. This work further incorporates learnable Sobel-Feldman operators to enhance edges in the image and propose an effective way to concatenate them in the intermediate layers of our architecture. The experimental analysis is conducted by comparing deterministic learning and residual learning for the …
We propose a dual-domain cascade of U-nets (i.e. a "W-net") operating in both the spatial frequency and image domains to enhance low-dose CT (LDCT) images without the need for proprietary x-ray projection data. The central slice theorem motivated the use of the spatial frequency domain in place of the raw sinogram. Data were obtained from the AAPM Low-dose Grand Challenge. A combination of Fourier space (F) and/or image domain (I) U-nets and W-nets were trained with a multi-scale structural similarity and mean absolute error loss function to denoise filtered back projected (FBP) LDCT images wh…
Beihang University（北京航空航天大学）；Institute for Infocomm Research（资讯通信研究院）
The generative adversarial network (GAN) is successfully applied to study the perceptual single image superresolution (SISR). However, the GAN often tends to generate images with high frequency details being inconsistent with the real ones. Inspired by conventional detail enhancement algorithms, we propose a novel prior knowledge, the detail prior, to assist the GAN in alleviating this problem and restoring more realistic details. The proposed method, named DSRGAN, includes a well designed detail extraction algorithm to capture the most important high frequency information from images. Then, t…
