We developed a positron emission tomography (PET) system for multiple-isotope imaging. Our PET system, named multiple-isotope PET (MI-PET), can distinguish between different tracer nuclides using coincidence measurement of prompt gamma-rays, which are emitted after positron emission. In MI-PET imaging with a pure positron emitter and prompt-gamma emitter, because of the imperfectness of prompt gamma-ray detection, an image for a pure positron emitter taken by MI-PET is superposed by a positron-γ emitter. Therefore, in order to make isolated images of the pure positron emitter, we developed image reconstruction methods based on data subtraction specific to MI-PET. We tested two methods, subtraction between reconstructed images and subtraction between sinogram data. In both methods, normalization for position dependence of the prompt γ-ray sensitivity is required in addition to detector sensitivity normalization. For these normalizations, we performed normalization scans using cylindrical phantoms of the positron-gamma emitters Sc-44m and Na-22. A long period measurement using the activity decay of Sc-44m (Half-life 58.6 hours) elucidated that the acquisition ratio between the prompt gamma-rays coincided with PET event and pure PET event changes on the basis of object activities. Therefore, we developed a correction method that involves subtraction parameters dependent on the activities, i.e., the counting rate. From analysis of dual-tracer phantom images, data subtraction in the sinogram data with sensitivity correction gives a higher quality of isolated images for the pure positron emitter than those from image subtractions. Furthermore, from dual-isotope (F-18-FDG and Sc-44m) mouse imaging, we concluded that our developed method can be used for practical imaging of a living organism.
Instituto de Física Corpuscular (IFIC)（粒子物理研究所）；Universitat de València（瓦伦西亚大学）；Donostia International Physics Center（圣塞巴斯蒂安国际物理中心）；Ikerbasque (Basque Foundation for Science)（伊克尔巴斯基（巴斯克科学基金会））
Super-resolution positron emission tomography by intensity modulation: Proof of concept
Huazhong University of Science and Technology（华中科技大学）；Wuhan National Laboratory for Optoelectronics（武汉国家实验室（光电））；University of Science and Technology of China（中国科学技术大学）；The University of Chicago（芝加哥大学）
Positron Emission Tomography with quantum-entangled Compton events: first imaging results at clinically relevant activities
University of Zagreb（萨格勒布大学）；Institute for Medical Research and Occupational Health（医学研究与职业健康研究所）；University Hospital Centre Zagreb（萨格勒布大学医院中心）；School of Physics, University of Sydney（悉尼大学物理学院）；Instituto de Física Corpuscular (IFIC), CSIC-UV（粒子物理研究所（IFIC），西班牙国家研究委员会-瓦伦西亚大学）
Roadmap Towards Quantum Entanglement Positron Emission Tomography (QE-PET)
Institute of Physics, Jagiellonian University（雅盖隆大学物理研究所）；Center for Theranostics, Jagiellonian University（雅盖隆大学诊疗中心）；University of California Santa Cruz（加州大学圣克鲁兹分校）；Indian Institute of Technology Bombay（印度理工学院孟买分校）；The University of Tokyo（东京大学）；Institute for Medical Research and Occupational Health, Division of Radiation Protection（医学研究与职业健康研究所辐射防护部）；University of Sydney（悉尼大学）；University of Zagreb Faculty of Science, Department of Physics（萨格勒布大学理学院物理系）；ICTP South American Institute for Fundamental Research（ICTP南美基础研究所）；Universidade Federal de São Paulo（圣保罗联邦大学）；Instituto de Fisica Corpuscular (IFIC), CSIC-UV（粒子物理研究所（IFIC），西班牙国家研究委员会-瓦伦西亚大学）；University of Illinois Urbana–Champaign（伊利诺伊大学厄巴纳-香槟分校）；National Institutes for Quantum Science and Technology（国立量子科学技术研究院）；Institute of Science Tokyo（东京科学研究所）
Renal Blood Flow Quantification During Standard Myocardial Perfusion Imaging with Rubidium-82 Positron Emission Tomography
University of British Columbia（不列颠哥伦比亚大学）；BC Cancer Research Institute（BC癌症研究所）；Perelman School of Medicine, University of Pennsylvania（宾夕法尼亚大学佩雷尔曼医学院）；Tawam Hospital/Johns Hopkins International and College of Medicine and Health Sciences Al Ain, Abu Dhabi, United Arab Emirates（塔瓦姆医院/约翰霍普金斯国际阿拉因医学院与卫生科学学院）；Hospital of the University of Pennsylvania（宾夕法尼亚大学医院）
研究探讨了在标准心肌灌注成像中使用 rubidium-82 PET 量化肾脏血流的可行性及生理有效性，发现肾脏 K1 值与肾功能密切相关，且在肾功能下降时显著降低。
A new approach to position reconstruction in TOFPET
蒙特卡罗模拟（MCS）是一种设计用于各种科学和技术应用的复杂装置的最先进的技术。采用基于GEANT（GEometry ANd Tracking）的MCS设计了一种简单的飞行时间正电子发射断层成像（TOFPET）。在MCS研究中，发展了一种新的正电子-电子湮灭点位置重建方法。仿真结果表明，这种技术可能是没有用的小动物成像相机，但可能是可行的诊断TOFPET相机。这种模拟技术的具体问题进行了讨论。
GLOW-FDG: Generalized cancer LesiOn Whole-body segmentation model for $^{18}$F-FDG-PET/CT
Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland（苏黎世大学放射肿瘤科，苏黎世大学，苏黎世，瑞士）；Faculty of Medicine, University of Zurich, Zurich, Switzerland（苏黎世大学医学院，苏黎世，瑞士）；Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany（德国癌症研究中心（DKFZ）医学图像计算部，海德堡，德国）；Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France（洛林癌症研究所放射肿瘤科，法国 Vandœuvre-lès-Nancy）；Department of Thoracic Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland（苏黎世大学胸外科科，苏黎世大学，苏黎世，瑞士）；ETOP IBCSG Partners Foundation, Bern, Switzerland（ETOP IBCSG合作伙伴基金会，瑞士伯恩）；Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland（苏黎世大学核医学科，苏黎世大学，苏黎世，瑞士）
Integration of Spectral CT with PET and SPECT: Bringing Tissue Composition Information to Molecular Imaging
University of California Davis Health（加州大学戴维斯分校健康中心）；University College London（伦敦大学学院）；University of Pennsylvania（宾夕法尼亚大学）；University of Washington（华盛顿大学）
Fast PET Scan Tumor Segmentation using Superpixels, Principal Component Analysis and K-means Clustering
Erasmus+ Joint Program in Medical Imaging and Applications, University of Burgundy (France), UNICLAM (Italy) and University of Girona (Spain)（伊拉斯谟+医学影像与应用联合项目，勃艮第大学（法国）、UNICLAM（意大利）与赫罗纳大学（西班牙））
Multibranch Generative Models for Multichannel Imaging with an Application to PET/CT Synergistic Reconstruction
Univ. Brest, LaTIM, INSERM, UMR 1101（布雷斯特大学、LaTIM研究所、法国国家健康与医学研究院、UMR 1101联合研究单位）；Nuclear Medicine Department, Poitiers University Hospital（普瓦捷大学医院核医学科）
