In this study we address the feasibility and main properties of a positron emission tomograph (PET) based on RPCs. The concept, making use of the converter-plate principle, takes advantage of the intrinsic layered structure of RPCs and its simple and economic construction. The extremely good time and position resolutions of RPCs also allow the TOF-PET imaging technique to be considered. Monte-Carlo simulations, supported by experimental data, are presented and the main advantages and drawbacks for applications of potential interest are discussed.
The EndoTOFPET-US project aims to jointly exploit Time-Of-Flight Positron Emission Tomography (TOFPET) and ultrasound endoscopy with a multi-modal instrument for the development of new biomarkers for pancreas and prostate oncology. The paper outlines the functionality of the proposed instrument and the challenges for its realization. The high level of miniaturization and integration poses strong demands to the fields of scintillating crystallography, ultra-fast photon detection, highly integrated electronics and system integration. Solutions are presented to obtain a coincidence time resolutio…
PET is a functional imaging technique based on detection of annihilation photons following beta decay producing positrons. In this paper, we present the concept of a new PET system for preclinical applications consisting of a ring of twelve time projection chambers filled with liquid xenon viewed by avalanche photodiodes. Simultaneous measurement of ionization charge and scintillation light leads to a significant improvement to spatial resolution, image quality, and sensitivity. Simulated performance shows that an energy resolution of <10% (FWHM) and a sensitivity of 15% are achievable. First …
In the present ongoing study, we are proposing a prototype model for positron emission tomography detection technology by introduction of a new discriminatory window parameter. It can be a new generation PET detection technique. We introduced Polarization Measurement of the annihilation photons(generated from the annihilation of positron and electron) as an additional parameter in proposed prototype, to correlate annihilation photons of a particular annihilation event. The motivation behind this introduction is Quantum Entanglement relation between the two annihilation photons. These two oppos…
This paper describes three methods regarding the production of plastic scintillators. One method appears to be suitable for the manufacturing of plastic scintillator, revealing properties which fulfill the requirements of novel positron emission tomography scanners based on plastic scintillators. The key parameters of the manufacturing process are determined and discussed.
The main challenges posed by the design of future Positron Emission Tomography machines are the improvement of the spatial and timing resolution and the combined operation with magnetic resonance. The Micro Pixel Photon Counter by Hamamatsu is a good candidate for this application. Its small size (down to 1 mm2) and the high photo-detection efficiency in the blue spectral region allow the direct readout of a highly segmented scintillator matrix improving the spatial resolution of the machine. Furthermore, this photo-detector is insensitive to static magnetic fields up to 5 T, which makes it a …
This article presents a novel technique for precise measurement of time and charge based solely on FPGA (Field Programmable Gate Array) device and few satellite discrete electronic components used in Positron Emission Tomography (PET). Described approach simplifies electronic circuits, reduces the power consumption, lowers costs, merges front-end electronics with digital electronics and also makes more compact final design. Furthermore, it allows to measure time when analog signals cross a reference voltage at different threshold levels with a very high precision of $\sim$ 10ps (rms) and thus …
Time-Of-Flight (TOF) is a noble technique that is used in Positron Emission Tomography (PET) imaging worldwide. The scintillator based imaging system that is being used around the world for TOF-PET is very expensive. Multi-gap Resistive Plate Chambers (MRPCs) are gaseous detectors which are easy to fabricate, inexpensive and have excellent position and timing resolution. They can be used as a suitable alternative to highly expensive scintillators. For the sole purpose of TOF-PET, a pair of 18 cm $\times$ 18 cm, 5 gap, glass-based MRPC modules have been fabricated. Our main aim was to determine…
Suspensions of superheated superconducting grains are a detecting composite material. Each grain in the supension is a microcalorimeter with an energy threshold defined by its equatorial magnetic field for a given temperature. The higher the matrix density, the larger the gamma stopping power. For several years, cylindrical cells of such suspensions about 2 cm long and 0.4 mm in diameter can be read out in real time. As a result, using two independent cells, one can record a time coincidence between them. This could be potentially very useful for positron cameras where two diametrically opposi…
We report on the measurements performed using a 22Na source on a detector element for an MRI-compatible TOF-PET endorectal prostate probe, with Depth-Of-Interaction sensitivity. It is made from a LYSO scintillator crystal, wrapped with Lumirror, readout at both ends by means of Silicon Photomultipliers. With a detailed description of the data analysis procedure we show that our results point to a 400 ps coincidence resolving time and, at the same time, to a Depth-Of-Interaction resolution of 1 mm. These appealing features, along with the tiny 1.5 mm x 1.5 mm x 10 mm crystal size, are quite pro…
In this contribution we describe a novel solution for the construction of Positron Emission Tomograph. We present the device allowing for determination of the impact position as well as time and deph of interaction of the annihilation gamma quanta. The device is comprised of scintillation chamber consisting of organic scintillators surrounding the body of the patient. We discuss two possible solutions: (i) the tomograph built out of scintillator strips, and (ii) the tomograph built out of the scintillator plates. The application of the fast scintillators will enable to take advantage of the di…
Positron Emission Tomography with quantum-entangled Compton events: first imaging results at clinically relevant activities
University of Zagreb（萨格勒布大学）；Institute for Medical Research and Occupational Health（医学研究与职业健康研究所）；University Hospital Centre Zagreb（萨格勒布大学医院中心）；School of Physics, University of Sydney（悉尼大学物理学院）；Instituto de Física Corpuscular (IFIC), CSIC-UV（粒子物理研究所（IFIC），西班牙国家研究委员会-瓦伦西亚大学）
Detection of $γ$-ray polarization in Positron Emission Tomography (PET) is as yet an unexploited feature that could be used as an additional handle to improve signal-to-background ratio in this imaging modality. The $γ$ polarization is related to the azimuthal angle in the Compton scattering process, so the initial correlation of polarizations of the annihilation quanta translates to the correlation of the azimuthal angles in events where both annihilation photons undergo Compton scattering. This results in a modulated distribution of the azimuthal angle difference for true events, while this …
Gamma-ray emission from special nuclear material (SNM) is relatively easy to shield from detection using modest amounts of high-Z material. In contrast, fast-neutrons are much more penetrating and can escape relatively thick high-Z shielding without losing significant energy. Furthermore, fast neutrons provide a clear and unambiguous signature of the presence of SNM with few competing natural background sources. The challenge of detecting fast neutrons is twofold. First, the neutron flux from SNM are only a fraction of the corresponding gamma-ray flux. Second, fast neutrons can be difficult to…
Currently inorganic scintillator detectors are used in all commercial Time of Flight Positron Emission Tomograph (TOF-PET) devices. The J-PET collaboration investigates a possibility of construction of a PET scanner from plastic scintillators which would allow for single bed imaging of the whole human body. This paper describes a novel method of hit-position reconstruction based on sampled signals and an example of an application of the method for a single module with a 30 cm long plastic strip, read out on both ends by Hamamatsu R4998 photomultipliers. The sampling scheme to generate a vector…
A novel Positron Emission Tomography system, based on plastic scintillators, is being developed by the J-PET collaboration. In this article we present the simulation results of the scatter fraction, representing one of the parameters crucial for background studies defined in the NEMA-NU-2-2012 norm. We elaborate an event selection methods allowing to suppress events in which gamma quanta were scattered in the phantom or underwent the multiple scattering in the detector. The estimated scatter fraction for the single-layer J-PET scanner varies from 37% to 53% depending on the applied energy thre…
J-PET Framework is an open-source software platform for data analysis, written in C++ and based on the ROOT package. It provides a common environment for implementation of reconstruction, calibration and filtering procedures, as well as for user-level analyses of Positron Emission Tomography data. The library contains a set of building blocks that can be combined by users with even little programming experience, into chains of processing tasks through a convenient, simple and well-documented API. The generic input-output interface allows processing the data from various sources: low-level data…
Transforming the resistive plate chambers from charged-particle into gamma-quanta detectors opens the way towards their application as a basic element of a hybrid imaging system, which combines positron emission tomography (PET) with magnetic resonance imaging (MRI) in a single device and provides non- and minimally- invasive quantitative methods for diagnostics. To this end, we performed detailed investigations encompassing the whole chain from the annihilation of the positron in the body, through the conversion of the created photons into electrons and to the optimization of the electron yie…
The possibility to separate signals caused by 511 keV photons created in annihilation of electron-positron pairs and the so-called prompt photons from nuclei de- excitation is investigated. It could potentially be used to improve the quality of reconstructed images in the J-PET scanner in 2+1 photon tomography. Firstly, a research is conducted for several radioisotopes that decay via \b{eta}+ decay followed by de-excitation of an excited nucleus. Efficiency, purity and false positive rate are calculated for each isotope as a function of energy deposited threshold, with a hypothesis that signal…
PETALO (Positron Emission Tof Apparatus with Liquid xenOn) is a novel concept for positron emission tomography scanners, which uses liquid xenon as a scintillation medium and silicon photomultipliers as a readout. The large scintillation yield and the fast scintillation time of liquid xenon, as well as its scalability, makes it an excellent candidate for PET scanners with Time-of-Flight measurements, especially for total-body machines. A first prototype of PETALO is fully operating, devoted to demonstrate the potential of the concept, measuring the energy and time resolution and to test techni…
We present a study of the application of the Jagiellonian Positron Emission Tomograph (J-PET) for the registration of gamma quanta from decays of ortho-positronium (o-Ps). The J-PET is the first positron emission tomography scanner based on organic scintillators in contrast to all current PET scanners based on inorganic crystals. Monte Carlo simulations show that the J-PET as an axially symmetric and high acceptance scanner can be used as a multi-purpose detector well suited to pursue research including e.g. tests of discrete symmetries in decays of ortho-positronium in addition to the medical…
We are investigating a prototype virtual pinhole positron emission tomography (VP-PET) system for small animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consists of 0.6 mm pixelated Cadmium Zinc Telluride (CdZnTe). To validate the imaging experiment, we conducted a Monte Carlo simulation for the VP-PET system in Geant4 Application for Emission Tomography (GATE). For a point source of Na-22 with 0.5 mm diameter, the filtered back-projection (FBP) algorithm reconstructed PET image shows a resolu…
Recent tests of a single module of the Jagiellonian Positron Emission Tomography system (J-PET) consisting of 30 cm long plastic scintillator strips have proven its applicability for the detection of annihilation quanta (0.511 MeV) with a coincidence resolving time (CRT) of 0.266 ns. The achieved resolution is almost by a factor of two better with respect to the current TOF-PET detectors and it can still be improved since, as it is shown in this article, the intrinsic limit of time resolution for the determination of time of the interaction of 0.511 MeV gamma quanta in plastic scintillators is…
Novel Positron Emission Tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.
PETALO (a Positron Emission Tof Apparatus based on Liquid xenOn) is a new approach for Positron Emission Tomography scanners, based on liquid xenon. The PETALO detector aims at capturing the light produced by the scintillation in LXe taking advantage of its uniform response and continuity. This strategy will lead to a geometrical distortion free behavior compared to other PET detectors. To this end, the sensors chosen for the light readout are SiPMs, which provide large area, high gain and very low noise. In order to take advantage of the unique PETALO detector characteristics a read-out archi…
Positron Emission Tomography (PET) using time-of-flight information, which can greatly improve the quality of the reconstructed image, has recently become an exciting topic. In this work, 3.2mm*3.2mm*25mm finger-like LYSO crystals were used to make a 5*5 array, coupled to the Hamamatsu H8500 photomultiplier tube (PMT) as a detector. A fast leading-edge discriminator was designed for the LYSO-H8500 detector. Average coincidence time resolution FWHM of 330 ps was obtained for the LYSO detector with a reference BaF2 detector, whose time resolution for 511 keV γ-rays was FWHM 150 ps. Time resoluti…
