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arXiv 2006.01504physics.ins-detphysics.bio-ph
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基于康普顿X射线散射的成像新技术

A new imaging technology based on Compton X-ray scattering

Ángela Saá Hernández, Diego González-Díaz, Pablo Villanueva, Carlos Azevedo, Marcos Seoane

摘要:

我们描述了一种可行的实现方案的一种新型的X射线探测器的高能X射线光子具有大的立体角覆盖,最佳的康普顿X射线散射光子的检测。该装置由一个20厘米厚的充满大气压氙气的敏感体组成。当康普顿散射的光子与氙相互作用时,释放的光电子产生二次电离云,这些云使用定制的多孔丙烯酸结构中产生的电致发光成像。可以通过处理以连续读出模式拍摄的所得图像来实现逐光子计数。Geant 4模拟的基础上,通过考虑一个现实的探测器设计和响应,我们表明,光子速率高达至少$10^{11}$ ph/s的样品($5~μ$ m水当量电池)可以处理,限制了光电子在气体中的空间扩散。说明性地,如果利用玫瑰准则和假设的剂量分配定理,我们展示了这样的探测器将如何允许获得三维图像的$5~μ$ m大小的未染色细胞在其原生环境中在约24小时,分辨率为36 nm。

英文摘要:

We describe a feasible implementation of a novel X-ray detector for highly energetic x-ray photons with a large solid angle coverage, optimal for the detection of Compton x-ray scattered photons. The device consists of a 20~cm-thick sensitive volume filled with xenon at atmospheric pressure. When the Compton-scattered photons interact with the xenon, the released photoelectrons create clouds of secondary ionization, which are imaged using the electroluminescence produced in a custom-made multi-hole acrylic structure. Photon-by-photon counting can be achieved by processing the resulting image, taken in a continuous readout mode. Based on Geant4 simulations, by considering a realistic detector design and response, we show that photon rates up to at least $10^{11}$ ph/s on-sample ($5~μ$m water-equivalent cell) can be processed, limited by the spatial diffusion of the photoelectrons in the gas. Illustratively, if making use of the Rose criterion and assuming the dose partitioning theorem, we show how such a detector would allow obtaining 3d images of $5~μ$m-size unstained cells in their native environment in about 24~h, with a resolution of 36~nm.

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