Optimisation of a diamond nitrogen vacancy centre magnetometer for sensing of biological signals
James Webb, Luca Troise, Nikolaj W. Hansen, Jocelyn Achard, Ovidiu Brinza, Robert Staacke, Michael Kieschnick, Jan Meijer, Jean-François Perrier, Kirstine Berg … 展开作者
James Webb, Luca Troise, Nikolaj W. Hansen, Jocelyn Achard, Ovidiu Brinza, Robert Staacke, Michael Kieschnick, Jan Meijer, Jean-François Perrier, Kirstine Berg Sørensen, Alexander Huck, Ulrik Lund Andersen
Sensing of signals from biological processes, such as action potential propagation in nerves, are essential for clinical diagnosis and basic understanding of physiology. Sensing can be performed electrically by placing sensor probes near or inside a living specimen or dissected tissue using well established electrophysiology techniques. However, these electrical probe techniques have poor spatial resolution and cannot easily access tissue deep within a living subject, in particular within the brain. An alternative approach is to detect the magnetic field induced by the passage of the electrical signal, giving the equivalent readout without direct electrical contact. Such measurements are performed today using bulky and expensive superconducting sensors with poor spatial resolution. An alternative is to use nitrogen vacancy (NV) centres in diamond that promise biocompatibilty and high sensitivity without cryogenic cooling. In this work we present advances in biomagnetometry using NV centres, demonstrating magnetic field sensitivity of approximately 100 pT/$\sqrt{Hz}$ in the DC/low frequency range using a setup designed for biological measurements. Biocompatibility of the setup with a living sample (mouse brain slice) is studied and optimized, and we show work toward sensitivity improvements using a pulsed magnetometry scheme. In addition to the bulk magnetometry study, systematic artifacts in NV-ensemble widefield fluorescence imaging are investigated.
Silicon vacancy in silicon carbide has drawn much attention for various quantum sensing. However, most of the previous experiments are achieved using confocal scanning systems, which limit its applications in practical applications. In this work, we demonstrate a compact fiber-integrated silicon carbide silicon vacancy-based vector magnetometer at room temperature. First, we effectively couple the silicon vacancy in a tiny silicon carbide slice to an optical fiber tip and realize the readout of the spin signal through the fiber at the same time. We then study the optically detected magnetic re…
Magnetic field sensors that exploit quantum effects have shown that they can outperform classical sensors in terms of sensitivity enabling a range of novel applications in future, such as a brain machine interface. Negatively charged nitrogen-vacancy (NV) centers in diamond have emerged as a promising high sensitivity platform for measuring magnetic fields at room temperature. Transferring this technology from laboratory setups into products and applications, the total size of the sensor, the overall power consumption, and the costs need to be reduced and optimized. Here, we demonstrate a fibe…
Diamond nitrogen-vacancy (NV) center magnetometry has recently received considerable interest from researchers in the fields of applied physics and sensors. The purpose of this review is to analyze the principle, sensitivity, technical development potential, and application prospect of the diamond NV center magnetometry. This review briefly introduces the physical characteristics of NV centers, summarizes basic principles of the NV center magnetometer, analyzes the theoretical sensitivity, and discusses the impact of technical noise on the NV center magnetometer. Furthermore, the most critical…
Improved constraints on exotic spin-dependent interactions are established at the micrometer scale by a magnetometer with ensembles of nitrogen-vacancy (NV) centers in diamond. A thin layer of NV electronic spin ensembles is utilized as the sensor, and a lead sphere is taken as the source of the nucleons. The exotic spin-dependent interactions are explored by detecting the possible effective magnetic fields by the sensor. Stringent bounds on an exotic parity-odd spin- and velocity-dependent interaction are set within the force range from 5 to 500 $μ$m. The upper limit of the corresponding coup…
Single-Spin Nitrogen-Vacancy Hybrid Magnetometer with Enhanced Static Field Sensitivity
University of Calgary（卡尔加里大学）；Max Planck Institute for Biophysical Chemistry（马克斯·普朗克生物物理化学研究所）；Sichuan University of Science and Engineering（四川理工学院）；QNeura；VinUniversity（越南大学）；XeedQ GmbH（XeedQ有限公司）
Magnetic sensing and imaging instruments are important tools in biological and material sciences. There is an increasing demand for attaining higher sensitivity and spatial resolution, with implementations using a single qubit offering potential improvements in both directions. In this article we describe a scanning magnetometer based on the nitrogen-vacancy center in diamond as the sensor. By means of a quantum-assisted readout scheme together with advances in photon collection efficiency, our device exhibits an enhancement in signal to noise ratio of close to an order of magnitude compared t…
We describe here the construction and characterization of a high-resolution optical magnetometer to measure the full vector magnetic field on an ultrathin layer near the surface of the device. This solid-state device is based on quantum sensors created by a layer of nitrogen-vacancy (NV) centers less than 20 nm below the surface of an ultrapure diamond. This ensemble of nanosensors provides a versatile device capable of mapping magnetic fields and surface current densities with a sub-micrometer resolution and high sensitivity, making it suitable for many applications. Here, we show a custom-bu…
Nitrogen-vacancy quantum defects in diamond offer a promising platform for magnetometry because of their remarkable optical and spin properties. In this Letter, we present a high-sensitivity and wide-bandwidth fiber-based quantum magnetometer for practical applications. By coating the diamond surface with silver reflective film, both the fluorescence collection and excitation efficiency are enhanced. Additionally, tracking pulsed optically detected magnetic resonance spectrum allowed a magnetic field sensitivity of $35$ pT$/\sqrt{\rm{Hz}}$ and a bandwidth of $4.1$ KHz. Finally, this magnetomet…
We report a new method to determine the orientation of individual nitrogen-vacancy (NV) centers in a bulk diamond and use them to realize a calibration-free vector magnetometer with nanoscale resolution. Optical vortex beam is used for optical excitation and scanning the NV center in a [111]-oriented diamond. The scanning fluorescence patterns of NV center with different orientations are completely different. Thus, the orientation information on each NV center in the lattice can be known directly without any calibration process. Further, we use three differently oriented NV centers to form a m…
Squeezing for dispersive readout of NV magnetometer
Russian Quantum Center（俄罗斯量子中心）；Moscow Institute of Physics and Technology（莫斯科物理工程技术学院）；P.N.Lebedev Physical Institute of the Russian Academy of Science（俄罗斯科学院列别杰夫物理研究所）；LLC Sensor Spin Technologies（传感器自旋技术有限责任公司）
We present an experimental method to perform dual-channel lock-in magnetometry of time-dependent magnetic fields using a single spin associated with a nitrogen-vacancy (NV) color center in diamond. We incorporate multi-pulse quantum sensing sequences with phase estimation algorithms to achieve linearized field readout and constant, nearly decoherence-limited sensitivity over a wide dynamic range. Furthermore, we demonstrate unambiguous reconstruction of the amplitude and phase of the magnetic field. We show that our technique can be applied to measure random phase jumps in the magnetic field, …
We demonstrate a robust, scale-factor-free vector magnetometer, which uses a closed-loop frequency-locking scheme to simultaneously track Zeeman-split resonance pairs of nitrogen-vacancy (NV) centers in diamond. Compared with open-loop methodologies, this technique is robust against fluctuations in temperature, resonance linewidth, and contrast; offers a three-order-of-magnitude increase in dynamic range; and allows for simultaneous interrogation of multiple transition frequencies. By directly detecting the resonance frequencies of NV centers aligned along each of the diamond's four tetrahedra…
We study relaxation processes of the spins of dipolar-coupled negatively charged nitrogen vacancy (NV$^-$) centers under transverse electric and magnetic fields. Specifically, we uncover regimes where flip-flop, double-flip processes as well as mixing induced by local electric fields play a significant role in NV-NV cross-relaxation. Our results are relevant for understanding decoherence in many-body spin systems as well as for high sensitivity magneto- and electro-metry with long-lived interacting solid-state spins. As a proof of principle, we present an orientation and microwave-free magneto…
A single nitrogen-vacancy (NV) center in diamond is a prime candidate for a solid-state quantum magnetometer capable of detecting single nuclear spins with prospective application to nuclear magnetic resonance (NMR) at the nanoscale. Nonetheless, an NV magnetometer is still less accessible to many chemists and biologists, as its experimental setup and operational principle are starkly different from those of conventional NMR. Here, we design, construct, and operate a compact tabletop-sized system for quantum sensing with a single NV center, built primarily from commercially available optical c…
Etching experiments were performed that reveal the vertical distribution of optically active nitrogen-vacancy (NV) centers in diamond created in close proximity to a surface through ion implantation and annealing. The NV distribution depends strongly on the native nitrogen concentration, and spectral measurements of the neutral and negatively-charged NV peaks give evidence for electron depletion effects in lower-nitrogen material. The results are important for potential quantum information and magnetometer devices where NV centers must be created in close proximity to a surface for coupling to…
Quantum sensing of low-frequency magnetic fields using nitrogen-vacancy (NV) center ensembles has been demonstrated in multiple experiments with sensitivities as low as $\sim$1 pT/$\sqrt{\text{Hz}}$. To date, however, demonstrations of high-frequency magnetometry in the GHz regime with NV diamond are orders of magnitude less sensitive, above the nT/$\sqrt{\text{Hz}}$ level. Here we adapt for microwave frequencies techniques that have enabled high-performance, low-frequency quantum sensors. Using a custom-grown NV-enriched diamond combined with a noise cancellation scheme designed for high-freq…
Ensembles of nitrogen-vacancy (NV) centers in diamonds are widely utilized for magnetometry, magnetic-field imaging and magnetic-resonance detection. They have not been used for magnetometry at zero ambient field because Zeeman sublevels lose first-order sensitivity to magnetic fields as they are mixed due to crystal strain or electric fields. In this work, we realize a zero-field (ZF) magnetometer using polarization-selective microwave excitation in a 12C-enriched HPHT crystal sample. We employ circularly polarized microwaves to address specific transitions in the optically detected magnetic …
We report on the implementation of a scanning nitrogen-vacancy (NV) magnetometer in a dry dilution refrigerator. Using pulsed optically detected magnetic resonance combined with efficient microwave delivery through a co-planar waveguide, we reach a base temperature of 350 mK, limited by experimental heat load and thermalization of the probe. We demonstrate scanning NV magnetometry by imaging superconducting vortices in a 50-nm-thin aluminum microstructure. The sensitivity of our measurements is approximately 3 μT per square root Hz. Our work demonstrates the feasibility for performing non-inva…
We present a highly sensitive miniaturized cavity-enhanced room-temperature magnetic-field sensor based on nitrogen-vacancy (NV) centers in diamond. The magnetic resonance signal is detected by probing absorption on the 1042\,nm spin-singlet transition. To improve the absorptive signal the diamond is placed in an optical resonator. The device has a magnetic-field sensitivity of 28 pT/$\sqrt{\rm{Hz}}$, a projected photon shot-noise-limited sensitivity of 22 pT/$\sqrt{\rm{Hz}}$ and an estimated quantum projection-noise-limited sensitivity of 0.43 pT/$\sqrt{\rm{Hz}}$ with the sensing volume of $\…
Ultimate sensitivity for quantum magnetometry using nitrogen-vacancy (NV) centers in diamond is limited by number of NV centers and coherence time. Microwave irradiation with a high and homogeneous power density for a large detection volume is necessary to achieve highly sensitive magnetometer. Here, we demonstrate a microwave resonator to enhance the power density of the microwave field and an optical system with a detection volume of 1.4e-3 mm$^3$. The strong microwave field enables us to achieve 48 ns Rabi oscillation which is sufficiently faster than the phase relaxation time of NV centers…
We present two fiberized vector magnetic-field sensors, based on nitrogen-vacancy (NV) centers in diamond. The sensors feature sub-nT/$\sqrt{\textrm{Hz}}$ magnetic sensitivity. We use commercially available components to construct sensors with a small sensor size, high photon collection, and minimal sensor-sample distance. Both sensors are located at the end of optical fibres with the sensor-head freely accessible and robust under movement. These features make them ideal for mapping magnetic fields with high sensitivity and spatial resolution ($\leq$\,mm). As a demonstration we use one of the …
Here, we demonstrate a gradiometry technique that significantly enhances the measurement sensitivity of such static fields, leading to new opportunities in the imaging of weakly magnetic systems. Our method relies on the mechanical oscillation of a single nitrogen-vacancy center at the tip of a scanning diamond probe, which up-converts the local spatial gradients into ac magnetic fields enabling the use of sensitive ac quantum protocols. We show that gradiometry provides important advantages over static field imaging: (i) an order-of-magnitude better sensitivity, (ii) a more localized and shar…
We demonstrate an absolute magnetometer immune to temperature fluctuation and strain inhomogeneity, based on quantum beats in the ground state of nitrogen-vacancy centers in diamond. We apply this technique to measure low-frequency magnetic field noise using a single nitrogen-vacancy center located within 500 nm of the surface of an isotopically-pure (99.99% C12) diamond. The photon-shot-noise limited sensitivity achieves 38 nT/Hz^1/2 for 4.45 s acquisition time, a factor of 2^1/2 better than the implementation which uses only two spin levels. For long acquisition times (>10 s), we realize up …
The confluence of quantum physics and biology is driving a new generation of quantum-based sensing and imaging technology capable of harnessing the power of quantum effects to provide tools to understand the fundamental processes of life. One of the most promising systems in this area is the nitrogen-vacancy centre in diamond - a natural spin qubit which remarkably has all the right attributes for nanoscale sensing in ambient biological conditions. Typically the nitrogen-vacancy qubits are fixed in tightly controlled/isolated experimental conditions. In this work quantum control principles of …
In this work, a burst eddy current testing technique based on the employment of a diamond nitrogen vacancy (NV) center magnetometer with the Hahn echo (HE) sequence is demonstrated. With the confocal experiment apparatus, the HE-based NV magnetometer attained a magnetic sensitivity of $4.3 ~ \mathrm{nT} / \sqrt{\mathrm{Hz}}$ and a volume-normalized sensitivity of $3.6 ~ \mathrm{pT} / \sqrt{\mathrm{Hz} \cdot \mathrm{mm}^{-3}}$, which are 5 times better than the already existing method under the same conditions. Based on the proposed magnetometer configuration, a burst eddy current (BEC) testing…
Magnetic Resonance Imaging (MRI) can characterize and discriminate among tissues using their diverse physical and biochemical properties. Unfortunately, submicrometer screening of biological specimens is presently not possible, mainly due to lack of detection sensitivity. Here we analyze the use of a nitrogen-vacancy center in diamond as a magnetic sensor for nanoscale nuclear spin imaging and spectroscopy. We examine the ability of such a sensor to probe the fluctuations of the "classical" dipolar field due to a large number of neighboring nuclear spins in a densely protonated sample. We iden…
We introduce a microwave-assisted spectroscopy technique to determine the relative concentrations of nitrogen vacancy (NV) centers in diamond that are negatively-charged (NV${}^-$) and neutrally-charged (NV${}^0$), and present its application to studying spin-dependent ionization in NV ensembles and enhancing NV-magnetometer sensitivity. Our technique is based on selectively modulating the NV${}^-$ fluorescence with a spin-state-resonant microwave drive to isolate, in-situ, the spectral shape of the NV${}^-$ and NV${}^0$ contributions to an NV-ensemble sample's fluorescence. As well as serving…
Dispersive readout with two orthogonal modes of a dielectric cavity
Russian Quantum Center（俄罗斯量子中心）；Moscow Institute of Physics and Technology（莫斯科物理技术学院）；P.N. Lebedev Institute RAS（列别捷夫物理研究所）；LLC Sensor Spin Technologies（传感器自旋技术有限公司）；National Research Nuclear University “MEPhI”（国立研究核子大学“莫斯科工程物理学院”）；LLC Velman（韦尔曼有限公司）；B.I. Stepanov Institute of Physics NASB（白俄罗斯国家科学院B.I.斯特潘诺夫物理研究所）
The sensitivity of a practical quantum magnetometer is challenged by both inhomogeneous coupling between sensors and environment and errors in quantum control. Based on the physical criteria of modern quantum sensing, we present a robust and effective composite-pulse for high fidelity operation against inhomogeneous broadening of sensor and control errors via optimized modulation of control field. Such a technique is verified on nitrogen-vacancy (NV) center in diamond to keep almost perfect operation up to a detuning as larger as $110\%$. The sensitivity of the magnetometer with NV center ense…
Magnetometers based on ensembles of nitrogen-vacancy centres are a promising platform for continuously sensing static and low-frequency magnetic fields. Their combination with phase-sensitive (lock-in) detection creates a highly versatile sensor with a sensitivity that is proportional to the derivative of the optical magnetic resonance lock-in spectrum, which is in turn dependant on the lock-in modulation parameters. Here we study the dependence of the lock-in spectral slope on the modulation of the spin-driving microwave field. Given the presence of the intrinsic nitrogen hyperfine spin trans…
Nanoscale electronic transport gives rise to a number of intriguing physical phenomena that are accompanied by distinct spatial patterns of current flow. Here, we report on sensitive magnetic imaging of two-dimensional current distributions in bilayer graphene at room temperature. By combining dynamical modulation of the source-drain current with ac quantum sensing of a nitrogen-vacancy center in a diamond probe, we acquire magnetic field and current density maps with excellent sensitivities of 4.6 nT and 20 nA/$μ$m, respectively. The spatial resolution is 50-100 nm. We further introduce a set…
Nitrogen-vacancy (NV) centers in millimeter-scale diamond samples were produced by irradiation and subsequent annealing under varied conditions. The optical and spin relaxation properties of these samples were characterized using confocal microscopy, visible and infrared absorption, and optically detected magnetic resonance. The sample with the highest NV- concentration, approximately 16 ppm = 2.8 x 10^{18} cm^{-3}, was prepared with no observable traces of neutrally-charged vacancy defects. The effective transverse spin relaxation time for this sample was T2* = 118(48) ns, predominately limit…
New magnetometry techniques based on Nitrogen Vacancy (NV) defects in diamond have received much attention of late as a means to probe nanoscale magnetic environments. The sensitivity of a single NV magnetometer is primarily determined by the transverse spin relaxation time, $T_2$. Current approaches to improving the sensitivity employ crystals with a high NV density at the cost of spatial resolution, or extend $T_2$ via the manufacture of novel isotopically pure diamond crystals. We adopt a complementary approach, in which optimal dynamic decoupling techniques extend coherence times out to th…
Nitrogen vacancy (NV) color centers in diamond have emerged as highly versatile optical emitters that exhibit room temperature spin properties. These characteristics make NV centers ideal for magnetometry, which plays an important role in chemical and biological sensing applications. The integration of NV magnetometers with microfluidic systems could enable the study of isolated chemical and biological samples in a fluid environment with high spatial resolution. Here we demonstrate a method to perform localized magnetometry with nanometer spatial precision using a single NV center in a microfl…
We demonstrate a vector magnetometer that simultaneously measures all Cartesian components of a dynamic magnetic field using an ensemble of nitrogen-vacancy (NV) centers in a single-crystal diamond. Optical NV-diamond measurements provide high-sensitivity, broadband magnetometry under ambient or extreme physical conditions; and the fixed crystallographic axes inherent to this solid-state system enable vector sensing free from heading errors. In the present device, multi-channel lock-in detection extracts the magnetic-field-dependent spin resonance shifts of NVs oriented along all four tetrahed…
Adaptive feedback normally provides the greatest accuracy for optical phase measurements. New advances in nitrogen vacancy centre technology have enabled magnetometry via individual spin measurements, which are similar to optical phase measurements but with low visibility. The adaptive measurements that previously worked well with high-visibility optical interferometry break down and give poor results for nitrogen vacancy centre measurements. We use advanced search techniques based on swarm optimisation to design better adaptive measurements that can provide improved measurement accuracy with …
