arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 0808.0630q-bio.PEcond-mat.stat-mech
收藏

带突变率修正的拟种模型的精确相图

Exact phase diagram of quasispecies model with mutation rate modifier

Apoorva Nagar, Kavita Jain

摘要:

我们考虑一个无限的无性群体,该群体具有一个可以提高突变率的突变等位基因。在概率为$f$的情况下,发生从非突变体到突变体状态的转变,但禁止反向转变。我们发现在$f=0$时,群体处于突变率最小的状态,而在$f=f_c$时,发生了一个由非突变体和突变体的混合相到纯突变体相的相变。我们精确地计算了混合相中突变子的临界概率$f_c$和总突变子分数$Q$。我们对$Q$的预测与静态环境中微生物种群的预测一致。

英文摘要:

We consider an infinite asexual population with a mutator allele which can elevate mutation rates. With probability $f$, a transition from nonmutator to mutator state occurs but the reverse transition is forbidden. We find that at $f=0$, the population is in the state with minimum mutation rate and at $f=f_c$, a phase transition occurs between a mixed phase with both nonmutators and mutators and a pure mutator phase. We calculate the critical probability $f_c$ and the total mutator fraction $Q$ in the mixed phase exactly. Our predictions for $Q$ are in agreement with those seen in microbial populations in static environments.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑