准种协同进化中的周期性与间歇性适应循环
Periodic vs. intermittent adaptive cycles in quasispecies co-evolution
摘要：
我们研究了变异病毒和适应性免疫系统之间的协同进化的抽象模型。在序列空间中，这两个群体都位于瞬时显性菌株周围。离域或错误阈值表现出一种新的相互依赖性，因为免疫反应是有条件的病毒攻击。进化追逐是由随机波动引起的，可以通过周期性或间歇性循环发生。使用模拟和随机分析，我们展示了如何这两个动态制度之间的过渡取决于突变率，免疫反应，和人口规模。
英文摘要：
We study an abstract model for the co-evolution between mutating viruses and the adaptive immune system. In sequence space, these two populations are localized around transiently dominant strains. Delocalization or error thresholds exhibit a novel interdependence because immune response is conditional on the viral attack. An evolutionary chase is induced by stochastic fluctuations and can occur via periodic or intermittent cycles. Using simulations and stochastic analysis, we show how the transition between these two dynamic regimes depends on mutation rate, immune response, and population size.
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