Cardiac Magnetic Resonance (CMR) images are widely used for cardiac diagnosis and ventricular assessment. Extracting specific landmarks like the right ventricular insertion points is of importance for spatial alignment and 3D modeling. The automatic detection of such landmarks has been tackled by multiple groups using Deep Learning, but relatively little attention has been paid to the failure cases of evaluation metrics in this field. In this work, we extended the public ACDC dataset with additional labels of the right ventricular insertion points and compare different variants of a heatmap-based landmark detection pipeline. In this comparison, we demonstrate very likely pitfalls of apparently simple detection and localisation metrics which highlights the importance of a clear detection strategy and the definition of an upper limit for localisation-based metrics. Our preliminary results indicate that a combination of different metrics is necessary, as they yield different winners for method comparison. Additionally, they highlight the need of a comprehensive metric description and evaluation standardisation, especially for the error cases where no metrics could be computed or where no lower/upper boundary of a metric exists. Code and labels: https://github.com/Cardio-AI/rvip_landmark_detection
University of Auckland（奥克兰大学）；Queen Mary University of London（伦敦玛丽女王大学）；University of Oxford（牛津大学）
Purpose: To demonstrate the feasibility and performance of a fully automated deep learning framework to estimate myocardial strain from short-axis cardiac magnetic resonance tagged images. Methods and Materials: In this retrospective cross-sectional study, 4508 cases from the UK Biobank were split randomly into 3244 training and 812 validation cases, and 452 test cases. Ground truth myocardial landmarks were defined and tracked by manual initialization and correction of deformable image registration using previously validated software with five readers. The fully automatic framework consisted …
Imperial College London（帝国理工学院）；MRC London Institute of Medical Sciences（MRC伦敦医学科学研究所）；National Heart and Lung Institute（国家心肺研究所）
Deep learning approaches have achieved state-of-the-art performance in cardiac magnetic resonance (CMR) image segmentation. However, most approaches have focused on learning image intensity features for segmentation, whereas the incorporation of anatomical shape priors has received less attention. In this paper, we combine a multi-task deep learning approach with atlas propagation to develop a shape-constrained bi-ventricular segmentation pipeline for short-axis CMR volumetric images. The pipeline first employs a fully convolutional network (FCN) that learns segmentation and landmark localisat…
View planning for the acquisition of cardiac magnetic resonance imaging (CMR) requires acquaintance with the cardiac anatomy and remains a challenging task in clinical practice. Existing approaches to its automation relied either on an additional volumetric image not typically acquired in clinic routine, or on laborious manual annotations of cardiac structural landmarks. This work presents a clinic-compatible and annotation-free system for automatic CMR view planning. The system mines the spatial relationship -- more specifically, locates and exploits the intersecting lines -- between the sour…
Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）；The University of Tokyo（东京大学）；Duke University（杜克大学）；Robarts Research Institute（罗伯茨研究所）；Western University（韦仕敦大学）；RIKEN（理化学研究所）
With the increasing availability of new image registration approaches, an unbiased evaluation is becoming more needed so that clinicians can choose the most suitable approaches for their applications. Current evaluations typically use landmarks in manually annotated datasets. As a result, the quality of annotations is crucial for unbiased comparisons. Even though most data providers claim to have quality control over their datasets, an objective third-party screening can be reassuring for intended users. In this study, we use the variogram to screen the manually annotated landmarks in two data…
Facial landmark detection plays an important role for the similarity analysis in artworks to compare portraits of the same or similar artists. With facial landmarks, portraits of different genres, such as paintings and prints, can be automatically aligned using control-point-based image registration. We propose a deep-learning-based method for facial landmark detection in high-resolution images of paintings and prints. It divides the task into a global network for coarse landmark prediction and multiple region networks for precise landmark refinement in regions of the eyes, nose, and mouth tha…
Towards a vision foundation model for comprehensive assessment of Cardiac MRI
Siemens Healthineers（西门子医疗）；Klinikum rechts der Isar, Technical University of Munich（慕尼黑工业大学 rechts der Isar 医院）；Siemens Healthineers AG（西门子医疗股份公司）；Imperial College London（伦敦帝国学院）
National Heart, Lung and Blood Institute, National Institutes of Health（美国国立卫生研究院心肺血液研究所）；Barts Heart Centre, Barts Health NHS Trust（巴特健康国民保健信托巴特心脏中心）；National Amyloidosis Centre, Royal Free Hospital（皇家自由医院国家淀粉样变性病中心）
Purpose: To develop a convolutional neural network (CNN) solution for robust landmark detection in cardiac MR images. Methods: This retrospective study included cine, LGE and T1 mapping scans from two hospitals. The training set included 2,329 patients and 34,019 images. A hold-out test set included 531 patients and 7,723 images. CNN models were developed to detect two mitral valve plane and apical points on long-axis (LAX) images. On short-axis (SAX) images, anterior and posterior RV insertion points and LV center were detected. Model outputs were compared to manual labels by two operators fo…
Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；Imperial College London（帝国理工学院）；Universitat de Barcelona（巴塞罗那大学）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Harbin Institute of Technology（哈尔滨工业大学）；Southern University of Science and Technology（南方科技大学）；Technical University of Munich（慕尼黑工业大学）；INRIA（法国国家信息与自动化研究所）；Université Côte d’Azur（蔚蓝海岸大学）；NVIDIA（英伟达）；Xiamen University（厦门大学）；Sichuan University（四川大学）；Tencent AI Lab（腾讯人工智能实验室）
Accurate computing, analysis and modeling of the ventricles and myocardium from medical images are important, especially in the diagnosis and treatment management for patients suffering from myocardial infarction (MI). Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) provides an important protocol to visualize MI. However, automated segmentation of LGE CMR is still challenging, due to the indistinguishable boundaries, heterogeneous intensity distribution and complex enhancement patterns of pathological myocardium from LGE CMR. Furthermore, compared with the other sequences LG…
University of Basel（巴塞尔大学）；University Hospital Basel（巴塞尔大学医院）；MIAC AG
We present an automated method for localizing an anatomical landmark in three-dimensional medical images. The method combines two recurrent neural networks in a coarse-to-fine approach: The first network determines a candidate neighborhood by analyzing the complete given image volume. The second network localizes the actual landmark precisely and accurately in the candidate neighborhood. Both networks take advantage of multi-dimensional gated recurrent units in their main layers, which allow for high model complexity with a comparatively small set of parameters. We localize the medullopontine …
Dense facial landmark detection is one of the key elements of face processing pipeline. It is used in virtual face reenactment, emotion recognition, driver status tracking, etc. Early approaches were suitable for facial landmark detection in controlled environments only, which is clearly insufficient. Neural networks have shown an astonishing qualitative improvement for in-the-wild face landmark detection problem, and are now being studied by many researchers in the field. Numerous bright ideas are proposed, often complimentary to each other. However, exploration of the whole volume of novel a…
Imperial College London（帝国理工学院）；UK Dementia Research Institute（英国痴呆症研究所）；MRC London Institute of Medical Sciences（医学研究理事会伦敦医学科学研究所）
The effectiveness of a cardiovascular magnetic resonance (CMR) scan depends on the ability of the operator to correctly tune the acquisition parameters to the subject being scanned and on the potential occurrence of imaging artefacts such as cardiac and respiratory motion. In the clinical practice, a quality control step is performed by visual assessment of the acquired images: however, this procedure is strongly operator-dependent, cumbersome and sometimes incompatible with the time constraints in clinical settings and large-scale studies. We propose a fast, fully-automated, learning-based qu…
Department of Computer Science, Rutgers University, Piscataway, NJ 08854, USA（美国新泽西州皮斯卡塔韦市罗格斯大学计算机科学系）
Adolescent idiopathic scoliosis (AIS) is a lifetime disease that arises in children. Accurate estimation of Cobb angles of the scoliosis is essential for clinicians to make diagnosis and treatment decisions. The Cobb angles are measured according to the vertebrae landmarks. Existing regression-based methods for the vertebra landmark detection typically suffer from large dense mapping parameters and inaccurate landmark localization. The segmentation-based methods tend to predict connected or corrupted vertebra masks. In this paper, we propose a novel vertebra-focused landmark detection method. …
Cascaded regression has been recently applied to reconstructing 3D faces from single 2D images directly in shape space, and achieved state-of-the-art performance. This paper investigates thoroughly such cascaded regression based 3D face reconstruction approaches from four perspectives that are not well studied yet: (i) The impact of the number of 2D landmarks; (ii) the impact of the number of 3D vertices; (iii) the way of using standalone automated landmark detection methods; and (iv) the convergence property. To answer these questions, a simplified cascaded regression based 3D face reconstruc…
The Chinese University of Hong Kong（香港中文大学）；Massachusetts Institute of Technology（麻省理工学院）
In medical imaging, surface registration is extensively used for performing systematic comparisons between anatomical structures, with a prime example being the highly convoluted brain cortical surfaces. To obtain a meaningful registration, a common approach is to identify prominent features on the surfaces and establish a low-distortion mapping between them with the feature correspondence encoded as landmark constraints. Prior registration works have primarily focused on using manually labeled landmarks and solving highly nonlinear optimization problems, which are time-consuming and hence hin…
This report presents a generic image registration benchmark with automatic evaluation using landmark annotations. The key features of the BIRL framework are: easily extendable, performance evaluation, parallel experimentation, simple visualisations, experiment's time-out limit, resuming unfinished experiments. From the research practice, we identified and focused on these two main use-cases: (a) comparison of user's (newly developed) method with some State-of-the-Art (SOTA) methods on a common dataset and (b) experimenting SOTA methods on user's custom dataset (which should contain landmark an…
Shandong University（山东大学）；University of Hong Kong（香港大学）；Texas A&M University（德克萨斯A&M大学）；Nanjing University（南京大学）
Artificial intelligence (AI) technology is increasingly used for digital orthodontics, but one of the challenges is to automatically and accurately detect tooth landmarks and axes. This is partly because of sophisticated geometric definitions of them, and partly due to large variations among individual tooth and across different types of tooth. As such, we propose a deep learning approach with a labeled dataset by professional dentists to the tooth landmark/axis detection on tooth model that are crucial for orthodontic treatments. Our method can extract not only tooth landmarks in the form of …
Sagol Brain Institute, Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心萨戈尔脑研究所）；University College London（伦敦大学学院）
Fetal growth assessment from ultrasound is based on a few biometric measurements that are performed manually and assessed relative to the expected gestational age. Reliable biometry estimation depends on the precise detection of landmarks in standard ultrasound planes. Manual annotation can be time-consuming and operator dependent task, and may results in high measurements variability. Existing methods for automatic fetal biometry rely on initial automatic fetal structure segmentation followed by geometric landmark detection. However, segmentation annotations are time-consuming and may be inac…
School of Mathematical Sciences, University of Science and Technology of China（中国科学技术大学数学科学学院）；School of Data Science, University of Science and Technology of China（中国科学技术大学数据科学学院）
Caricature is an artistic abstraction of the human face by distorting or exaggerating certain facial features, while still retains a likeness with the given face. Due to the large diversity of geometric and texture variations, automatic landmark detection and 3D face reconstruction for caricature is a challenging problem and has rarely been studied before. In this paper, we propose the first automatic method for this task by a novel 3D approach. To this end, we first build a dataset with various styles of 2D caricatures and their corresponding 3D shapes, and then build a parametric model on ve…
An objective comparison of methods for augmented reality in laparoscopic liver resection by preoperative-to-intraoperative image fusion
University of Leeds（利兹大学）；Centre Hospitalier Universitaire de Clermont-Ferrand（克莱蒙费朗大学医院中心）；National University of Singapore (NUS)（新加坡国立大学）；National Center for Tumor Diseases (NCT/UCC Dresden)（德国国家肿瘤疾病中心（德累斯顿））；Fudan University（复旦大学）；University of Pennsylvania（宾夕法尼亚大学）
Heidelberg University Hospital（海德堡大学医院）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；German Competence Network for Congenital Heart Defects（德国先天性心脏病能力网络）
Anisotropic multi-slice Cardiac Magnetic Resonance (CMR) Images are conventionally acquired in patient-specific short-axis (SAX) orientation. In specific cardiovascular diseases that affect right ventricular (RV) morphology, acquisitions in standard axial (AX) orientation are preferred by some investigators, due to potential superiority in RV volume measurement for treatment planning. Unfortunately, due to the rare occurrence of these diseases, data in this domain is scarce. Recent research in deep learning-based methods mainly focused on SAX CMR images and they had proven to be very successfu…
Heidelberg University Hospital（海德堡大学医院）；Mannheim University of Applied Sciences（曼海姆应用科学大学）
To support minimally-invasive intraoperative mitral valve repair, quantitative measurements from the valve can be obtained using an infra-red tracked stylus. It is desirable to view such manually measured points together with the endoscopic image for further assistance. Therefore, hand-eye calibration is required that links both coordinate systems and is a prerequisite to project the points onto the image plane. A complementary approach to this is to use a vision-based endoscopic stereo-setup to detect and triangulate points of interest, to obtain the 3D coordinates. In this paper, we aim to c…
Institute for Systems and Robotics（系统与机器人研究所）；Instituto Superior Técnico（高等理工学院）
In image analysis, many tasks require representing two-dimensional (2D) shape, often specified by a set of 2D points, for comparison purposes. The challenge of the representation is that it must not only capture the characteristics of the shape but also be invariant to relevant transformations. Invariance to geometric transformations, such as translation, rotation, and scale, has received attention in the past, usually under the assumption that the points are previously labeled, i.e., that the shape is characterized by an ordered set of landmarks. However, in many practical scenarios, the poin…
Panacea Cooperative Research S. Coop.（帕纳西亚合作研究合作社）；Andalusian Research Institute in Artificial Intelligence (DaSCI), University of Granada（格拉纳达大学安达卢西亚人工智能研究院（DaSCI））
Craniofacial Superimposition involves the superimposition of an image of a skull with a number of ante-mortem face images of an individual and the analysis of their morphological correspondence. Despite being used for one century, it is not yet a mature and fully accepted technique due to the absence of solid scientific approaches, significant reliability studies, and international standards. In this paper we present a comprehensive experimentation on the limitations of Craniofacial Superimposition as a forensic identification technique. The study involves different experiments over more than …
Zuse Institute Berlin（柏林祖斯研究所）；City University of Hong Kong（香港城市大学）；Freie Universität Berlin（柏林自由大学）
3D shapes provide substantially more information than 2D images. However, the acquisition of 3D shapes is sometimes very difficult or even impossible in comparison with acquiring 2D images, making it necessary to derive the 3D shape from 2D images. Although this is, in general, a mathematically ill-posed problem, it might be solved by constraining the problem formulation using prior information. Here, we present a new approach based on Kendall's shape space to reconstruct 3D shapes from single monocular 2D images. The work is motivated by an application to study the feeding behavior of the bas…
Deformable Image Registration for Self-supervised Cardiac Phase Detection in Multi-View Multi-Disease Cardiac Magnetic Resonance Images
Department of Internal Medicine III, Heidelberg University Hospital（海德堡大学第三内科部门医院）；Medical Faculty of Heidelberg University（海德堡大学医学院）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；Division of Pediatric Cardiology, Department of Pediatrics, UT Southwestern /Children’s Health（儿童心脏病科，德克萨斯西南医学中心/儿童健康）；Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School（汉诺威医学院心胸外科、移植外科和血管外科部门）
本文提出一种自监督深度学习方法，通过多视角多疾病心脏磁共振图像检测五个关键帧，提高了心脏相位检测的准确率，适用于SAX和4CH cine CMR。
Vision is one of the most important of the senses, and humans use it extensively during navigation. We evaluated different types of image and video frame descriptors that could be used to determine distinctive visual landmarks for localizing a person based on what is seen by a camera that they carry. To do this, we created a database containing over 3 km of video-sequences with ground-truth in the form of distance travelled along different corridors. Using this database, the accuracy of localization - both in terms of knowing which route a user is on - and in terms of position along a certain …
Resource-Aware Evolutionary Neural Architecture Search for Cardiac MRI Segmentation
School of Computer Science, Nanjing University of Information Science and Technology（南京信息工程大学计算机科学学院）；School of Software, Nanjing University of Information Science and Technology（南京信息工程大学软件学院）；Eastern University（东东大学）；Research Centre for Intelligent Healthcare, Coventry University（科文大学智能医疗研究中心）；National Medical Research Association（国家医学研究协会）；Faculty of Engineering and Technology, Muscat University（穆斯cat大学工程与技术学院）；College of Computer and Information Sciences, King Saud University（沙特国王大学计算机与信息学院）
A versatile foundation model for cine cardiac magnetic resonance image analysis tasks
UCL Hawkes Institute, Department of Medical Physics and Biomedical Engineering, University College London（伦敦大学霍克斯研究所、医学物理与生物医学工程系、伦敦大学学院）；InstaDeep；Department of Computing, Imperial College London（伦敦帝国学院计算机系）；Department of Brain Sciences, Imperial College London（伦敦帝国学院脑科学系）；Institute of Cardiovascular Sciences, University College London（伦敦大学学院心血管科学研究所）；Barts Heart Centre, Barts Health NHS Trust（巴特斯心脏中心、巴特斯健康 NHS信托）
