We consider a Parabolic-Elliptic system of PDE's with a chemotactic term in a $N$-dimensional unit ball describing the behavior of the density of a biological species "$u$" and a chemical stimulus "$v$". The system includes a
nonlinear chemotactic coefficient depending of ``$\nabla v$", i.e. the chemotactic term is given in the form $$- div (χu |\nabla v|^{p-2} \nabla v), \qquad \mbox{ for } \ p \in ( \frac{N}{N-1},2), \qquad N >2 $$ for a positive constant $χ$ when $v$ satisfies the poisson equation $$- Δv = u - \frac{1}{|Ω|} \int_Ω u_0dx.$$ We study the radially symmetric solutions under the assumption in the initial mass $$ \frac{1}{|Ω|} \int_Ω u_0dx>6.$$ For $χ$ large enough, we present conditions in the initial data, such that any regular solution of the problem blows up at finite time.
In this article we investigate a parabolic-parabolic-elliptic two-species chemotaxis system with weak competition and show global asymptotic stability of the coexistence steady state under a smallness condition on the chemotactic strengths, which seems more natural than the condition previously known. For the proof we rely on the method of eventual comparison, which thereby is shown to be a useful tool even in the presence of chemotactic terms.
Chemotaxis, the directional locomotion of cells towards a source of a chemical gradient, is an integral part of many biological processes - for example, bacteria motion, single-cell or multicellular organisms development, immune response, etc. Chemotaxis directs bacteria's movement to find food (e.g., glucose) by swimming toward the highest concentration of food molecules. In multicellular organisms, chemotaxis is critical to early development (e.g., movement of sperm towards the egg during fertilization). Chemotaxis also helps mobilize phagocytic and immune cells at sites of infection, tissue…
This paper deals with the two-species chemotaxis-competition models \begin{align*} \begin{cases} u_t = d_1 Δu - χ_1 \nabla \cdot (u \nabla w) + μ_1 u (1- u^{κ_1-1} - a_1 v^{λ_1-1}), &\quad x \in Ω,\ t>0,\\ % v_t = d_2 Δv - χ_2 \nabla \cdot (v \nabla w) + μ_2 v (1- a_2 u^{λ_2-1} - v^{κ_2-1}), &\quad x \in Ω,\ t>0,\\ % 0 = d_3 Δw + αu + βv - h(u,v,w), &\quad x \in Ω,\ t>0, \end{cases} \end{align*} where $Ω\subset \mathbb{R}^n$ $(n\ge2)$ is a bounded domain with smooth boundary, and $h=γw$ or $h=\frac{1}{|Ω|}\int_Ω(αu+ βv)\,dx$. In the case that $κ_1=λ_1=κ_2=λ_2=2$ and $h=γw$, it is known that sm…
Chemotaxis refers to the directed movement of cells in response to a chemical signal called chemoattractant. A crucial point in the mathematical modeling of chemotactic processes is the correct description of the chemotactic sensitivity and of the production rate of the chemoattractant. In this paper, we investigate the identification of these non-linear parameter functions in a chemotaxis model with volume filling. We also discuss the numerical realization of Tikhonov regularization for the stable solution of the inverse problem. Our theoretical findings are supported by numerical tests.
We consider a system coupling the parabolic-parabolic Keller-Segel equations to the in- compressible Navier-Stokes equations in spatial dimensions two and three. We establish the local existence of regular solutions and present some blow-up criteria. For two dimensional Navier-Stokes-Keller-Segel equations, regular solutions constructed locally in time are, in reality, extended globally under some assumptions pertinent to experimental observation in [20] on the consumption rate and chemotactic sensitivity. We also show the existence of global weak solutions in spatially three dimensions with r…
We consider a phenotype-switching chemotaxis model for aggregation, in which a chemotactic population is capable of switching back and forth between a chemotaxing state (performing chemotactic movement) and a secreting state (producing the attractant). We show that the switching rate provides a powerful mechanism for controlling the densities of spontaneously emerging aggregates. Specifically, in two- and three-dimensional settings it is shown that when both switching rates coincide and are suitably large, then the densities of both the chemotaxing and the secreting population will exceed any …
In this paper, we study the minimal Keller-Segel model with a logistic source and obtain quantitative and qualitative descriptions of the competition between logistic damping and other ingredient, especially, chemotactic aggregation to guarantee boundedness and convergence. More specifically, we establish how precisely strong a logistic source can prevent blow-up, and then we obtain an explicit relationship between logistic damping and other ingredient, especially, chemotactic aggregation so that convergences are ensured and their respective convergence rates are explicitly calculated out. Kno…
For the parabolic-elliptic Keller-Segel system in R^2 it has been proved that if the initial mass is less than 8π/χ global solution exist and in the case that the initial mass is larger than 8π/χ blow-up happens. The case of several chemotactic species introduces an additional question: What is the analog for the critical mass obtained for the single species system? We find a threshold curve in the case of two especies case that allows us to determine if the system has blow-up or has a global in time solution.
We consider a second order PDEs system of Parabolic-Elliptic type with chemotactic terms. The system describes the evolution of a biological species "$u$" moving towards a higher concentration of a chemical stimuli "$v$" in a bounded and open domain of $ \mathcal{R}^N$. In the system considered, the chemotaxis sensitivity depends on the gradient of $v$, i.e., the chemotaxis term has the following expression $$- div \left(χu |\nabla v|^{p-2}\nabla v \right),$$ where $χ$ is a positive constant and $p$ satisfies $$p \in (1, \infty), \quad \mbox{ if } N=1 \quad \mbox{ and } \quad p\in \left(1, \fr…
In this paper, we study chemotaxis effect vs logistic dampening on boundedness for the two-dimensional minimal Keller-Segel model with logistic source in a 2-D smooth and bounded domain. It is well-known that this model allows only for global and uniform-in-time bounded solutions for any chemotactic strength and logistic dampening. Here, we carefully employ a simple and new method to regain its boundedness and, with particular attention to how boundedness depends qualitatively on the coefficient of chemotactic strength and logistic dampening rate. Up to a scaling constant depending only on ini…
In this article we deal with a class of strongly coupled parabolic systems that encompasses two different effects: degenerate diffusion and chemotaxis. Such classes of equations arise in the mesoscale level modeling of biomass spreading mechanisms via chemotaxis. We show the existence of an exponential attractor and, hence, of a finite-dimensional global attractor under certain 'balance conditions' on the order of the degeneracy and the growth of the chemotactic function.
We consider the simplest parabolic-elliptic model of chemotaxis in the whole space in several dimensions. Criteria for the blowup of radially symmetric solutions in terms of suitable Morrey spaces norms are derived.
We revisit the question of global regularity for the Patlak-Keller-Segel (PKS) chemotaxis model. The classical 2D hyperbolic-elliptic model blows up for initial mass M>8π. We consider more realistic scenario which takes into account the flow of the ambient environment induced by harmonic potentials, and thus retain the identical elliptic structure as in the original PKS. Surprisingly, we find that already the simplest case of linear stationary vector field, $Ax^\top$, with large enough amplitude $A$, prevents chemotactic blow-up. Specifically, the presence of such an ambient fluid transport cr…
In this paper we study a two-dimensional chemotaxis-consumption system with singular sensitivity and endowed with Neumann boundary conditions. Sufficient conditions on the data of the problem are given so that the globability of classical solutions is shown, thus excluding any finite-time blow-up scenario.
By employing the Fourier transform to derive key a priori estimates for the temporal gradient of the chemical signal, we establish the existence of global solutions and hydrodynamic limit of a chemotactic kinetic model with internal states and temporal gradient in one dimension, which is a system of two transport equations coupled to a parabolic equation proposed in [4].
We consider two-dimensional versions of the Keller--Segel model for the chemotaxis with either classical (Brownian) or fractional (anomalous) diffusion. Criteria for blowup of solutions in terms of suitable Morrey spaces norms are derived. Moreover, the impact of the consumption term on the global-in-time existence of solutions is analyzed for the classical Keller--Segel system.
In this paper, we study a free boundary problem for a class of parabolic-elliptic type chemotaxis model in high dimensional symmetry domain Ω. By using the contraction mapping principle and operator semigroup approach, we establish the existence of the solution for such kind of chemotaxis system in the domain Ωwith free boundary condition. Besides, we get the explicit formula for the free boundary and show the chemotactic collapse for the solution of the system.
Finite time blow-up is shown to occur for solutions to a one-dimensional quasilinear parabolic-parabolic chemotaxis system as soon as the mean value of the initial condition exceeds some threshold value. The proof combines a novel identity of virial type with the boundedness from below of the Liapunov functional associated to the system, the latter being peculiar to the one-dimensional setting.
It is well-known that the Neumann initial-boundary value problem for the minimal-chemotaxis-logistic system in a 2D bounded smooth domain has no blow-up for any choice of parameters. Here, for a large class of kinetic terms including sub-logistic sources, we show that the corresponding 2D Neumann initial-boundary value problems do not possess any blow-up. This illustrates a new phenomenon that even a class of sub-logistic sources can prevent blow-up for the 2D problem, indicating that logistic damping is not the weakest damping to guarantee uniform-in-time boundedness for the 2D minimal Keller…
In this work, we rigorously study chemotaxis effect versus haptotaxis effect on boundedness, blow-up and asymptotical behavior of solutions for a combined chemotaxis-haptotaxis model in 2D settings. It is well-known that the corresponding Keller-Segel chemotaxis-only model possesses a striking feature of critical mass blow-up phenomenon, namely, subcritical mass ensures boundedness, whereas, supercritical mass induces the existence of blow-ups. Herein, we show that this critical mass blow-up phenomenon stays almost the same in the full chemotaxis-haptotaxis model. For negligibility of haptotax…
We consider an initial-boundary value problem describing the formation of colony patterns of bacteria Escherichia coli. This model consists of reaction-diffusion equations coupled with the Keller-Segel system from the chemotaxis theory in a bounded domain, supplemented with zero-flux boundary conditions and with non-negative initial data. We answer questions on the global in time existence of solutions as well as on their large time behaviour. Moreover, we show that solutions of a related model may blow up in a finite time.
We study a system of PDEs modeling the population dynamics of two competitive species whose spatial movements are governed by both diffusion and mutually repulsive chemotaxis effects. We prove that solutions to this system are globally well-posed, without any smallness assumptions on the chemotactic coefficients. Moreover, in the weak competition regime, we prove that neither species can be driven to extinction as the time goes to infinity, regardless of how strong the chemotaxis coefficients are. Finally, long-time behaviors of the system are studied both analytically in the weakly nonlinear …
We show that the attraction-repulsion chemotaxis system \begin{equation*} \begin{cases} u_t = Δu - χ\nabla\cdot(u\nabla v_1) + ξ\nabla\cdot(u\nabla v_2)\\ \partial_t v_1 = Δv_1 - βv_1 + αu \\ \partial_t v_2 = Δv_2 - δv_2 + γu, \end{cases} \end{equation*} posed with homogeneous Neumann boundary conditions in bounded domains $Ω=B_R \subset \mathbb{R}^3$, $R>0$, admits radially symmetric solutions which blow-up in finite time if it is attraction-dominated in the sense that $χα-ξγ>0$.
We consider two dimensional Keller-Segel equations coupled with the Navier-Stokes equations modelled by Tuval et al.[32]. Assuming that the chemotactic sensitivity and oxygen consumption rate are nondecreasing and differentiable, we prove that there is no blow-up in a finite time for solutions with large initial data to chemotaxis-Navier-Stokes equations in two dimensions. In addition, temporal decays of solutions are shown, as time tends to infinity.
As motivated by studies of cellular motility driven by spatiotemporal chemotactic gradients in microdevices, we develop a framework for constructing approximate analytical solutions for the location, speed and cellular densities for cell chemotaxis waves in heterogeneous fields of chemoattractant from the underlying partial differential equation models. In particular, such chemotactic waves are not in general translationally invariant travelling waves, but possess a spatial variation that evolves in time, and may even may oscillate back and forth in time, according to the details of the chemot…
This paper deals with the fully parabolic attraction-repulsion chemotaxis system \begin{align*} u_t=Δu-χ\nabla \cdot (u\nabla v)+ξ\nabla\cdot(u \nabla w), \quad v_t=Δv-v+u, \quad w_t=Δw-w+u, \quad x \in Ω,\ t>0 \end{align*} under homogeneous Neumann boundary conditions and initial conditions, where $Ω$ is an open ball in $\mathbb{R}^n$ ($n \ge 3$), $χ, ξ>0$ are constants. When $w=0$, finite-time blow-up in the corresponding Keller-Segel system has already been obtained. However, finite-time blow-up in the above attraction-repulsion chemotaxis system has not yet been established except for the …
We investigate the propagating profiles of a degenerate chemotaxis model describing the bacteria chemotaxis and consumption of oxygen by aerobic bacteria, in particular, the effect of the initial attractant distribution on bacterial clustering. We prove that the compact support of solutions may shrink if the signal concentration satisfies a special structure, and show the finite speed propagating property without assuming the special structure on attractant concentration, and obtain an explicit formula of the population spreading speed in terms of model parameters. The presented results sugges…
We consider a chemotaxis-fluid system involving nonlinear cell diffusion of porous medium type, signal consumption by cells, and rather general, possibly matrix-valued, chemotactic sensitivities. It is shown that if the corresponding diffusion exponent $m$ satisfies $m>7/6$, then for all reasonably regaular initial data an associated initial-boundary value problem in smoothly bounded three-dimensional domains possesses a globally defined weak solution which is bounded. Under a mild additional assumption on the signal consumption rate, it is moreover shown that any nontrivial of these solutions…
This paper deals with unbounded solutions to a class of chemotaxis systems. In particular, for a rather general attraction-repulsion model, with nonlinear productions, diffusion, sensitivities and logistic term, we detect Lebesgue spaces where given unbounded solutions blow-up also in the corresponding norms of those spaces; subsequently, estimates for the blow-up time are established. Finally, for a simplified version of the model, some blow-up criteria are proved.
This work considers a chemotaxis system for multi-species that includes birth or death rate terms, which implies no mass preservation of the populations. We aim to show the convergence to a $L^{\infty}\ -\ $weak solutions, that is local in time, of the JKO - scheme arising from the Optimal Transport Theory, in the spirit of [35,14]. Currently, $L^{\infty}$ solutions have shown to be important in order to get uniqueness. Since death rate case does not ensure global solutions, for arbitrary initial data, in this framework, it could be interest to analyze the Blowing-up phenomenon of this system.…
This paper is concerned with the attraction-repulsion chemotaxis system with superlinear logistic degradation, \begin{align*} \begin{cases} u_t = Δu - χ\nabla\cdot(u \nabla v) + ξ\nabla\cdot (u \nabla w) + λu - μu^k, \quad &x \in Ω,\ t>0,\\[1.05mm] 0= Δv + αu - βv, \quad &x \in Ω,\ t>0,\\[1.05mm] 0= Δw + γu - δw, \quad &x \in Ω,\ t>0, \end{cases} \end{align*} under homogeneous Neumann boundary conditions, in a ball $Ω\subset \mathbb{R}^n$ ($n \ge 3$), with constant parameters $λ\in \mathbb{R}$, $k>1$, $μ, χ, ξ, α, β, γ, δ>0$. Blow-up phenomena in the system have been well investigated in the c…
For a specific choice of the diffusion, the parabolic-elliptic Patlak-Keller-Segel system with non-linear diffusion (also referred to as the quasi-linear Smoluchowski-Poisson equation) exhibits an interesting threshold phenomenon: there is a critical mass $M_c>0$ such that all the solutions with initial data of mass smaller or equal to $M_c$ exist globally while the solution blows up in finite time for a large class of initial data with mass greater than $M_c$. Unlike in space dimension 2, finite mass self-similar blowing-up solutions are shown to exist in space dimension $d?3$.
This paper deals with the fully parabolic chemotaxis system of local sensing in higher dimensions. Despite the striking similarity between this system and the Keller--Segel system, we prove the absence of finite-time blow-up phenomenon in this system even in the supercritical case. It means that for any regular initial data, independently of the magnitude of mass, the classical solution exists globally in time in the higher dimensional setting. Moreover, for the exponential decaying motility case, it is established that solutions may blow up at infinite time for any magnitude of mass. In order…
In this paper we study a zero-flux attraction-repulsion che\-mo\-taxis-system. We show that despite any mutual interplay between the repulsive and attractive coefficients from the corresponding chemo-sensitivities, even less any restriction on their own sizes, if the production rate of that chemical signal responsible of the cellular coalescence is sublinear, then any initial data emanate a unique global classical solution, which is as well bounded. Further, in a remark of the manuscript, we also address an open question given in \cite{Viglialoro2019RepulsionAttraction}.
In this paper we consider nonnegative solutions of the following parabolic-elliptic cross-diffusion system \begin{equation*} \left\{ \begin{array}{l} \begin{aligned} &u_t = Δu - \nabla(u f(|\nabla v|^2 )\nabla v), \\[6pt] &0= Δv -μ+ u , \quad \int_Ωv =0, \ \ μ:= \frac 1 {|Ω|} \int_Ω u dx, \\[6pt] &u(x,0)= u_0(x), \end{aligned} \end{array} \right. \end{equation*} in $Ω\times (0,\infty)$, with $Ω$ a ball in $\mathbb{R}^N$, $N\geq 3$ under homogeneous Neumann boundary conditions and $f(ξ) = (1+ ξ)^{-α}$, $0<α< \frac{N-2}{2(N-1)}$, which describes gradient-dependent limitation of cross diffusion f…
This paper studies the non-negative solutions of the Keller-Segel model with a nonlocal nonlinear source in a bounded domain. The competition between the aggregation and the nonlocal reaction term is highlighted: when the growth factor is stronger than the dampening effect, with the help of the nonlocal term, the model admits a classical solution which is uniformly bounded. Moreover, when the growth factor is of the same order compared to the dampening effect, the nonlocal nonlinear exponents can prevent the chemotactic collapse. Global existence of classical solutions is shown for an appropri…
Chemotaxis is the process by which cells behave in a way that follows the chemical gradient. Applications to bacteria growth, tissue inflammation, and vascular tumors provide a focus on optimization strategies. Experiments can characterize the form of possible chemotactic sensitivities. This paper addresses the recovery of the chemotactic sensitivity from these experiments while allowing for nonlinear dependence of the parameter on the state variables. The existence of solutions to the forward problem is analyzed. The identification of a chemotactic parameter is determined by inverse problem t…
Collective motion of chemotactic bacteria as E. Coli relies, at the individual level, on a continuous reorientation by runs and tumbles. It has been established that the length of run is decided by a stiff response to a temporal sensingof chemical cues along the pathway.We describe a novel mechanism for pattern formation stemming from the stiffness of chemotactic response relying on a kinetic chemotaxis model which includes a recently discovered formalism for the bacterial chemotaxis. We prove instability both for amicroscopic description in the space-velocity space and for the macroscopic equ…
This paper deals with the quasilinear degenerate chemotaxis system with flux limitation \begin{align*} \begin{cases} u_t = \nabla\cdot\left(\dfrac{u^p \nabla u}{\sqrt{u^2 + |\nabla u|^2}} \right) -χ\nabla\cdot\left( \dfrac{u^q\nabla v}{\sqrt{1 + |\nabla v|^2}}\right), &x\in Ω,\ t>0, \\[1mm] 0 = Δv - μ+ u, &x\in Ω,\ t>0, \end{cases} \end{align*} where $Ω:= B_R(0) \subset \mathbb{R}^n$ ($n \in \mathbb{N}$) is a ball with some $R>0$, and $χ>0$, $p,q\geq1$, $μ:= \frac 1{|Ω|} \int_Ωu_0$ and $u_0$ is an initial data of an unknown function $u$. Bellomo--Winkler (Trans.\ Amer.\ Math.\ Soc.\ Ser.\ B;20…
This paper deals with the quasilinear parabolic-elliptic chemotaxis system with logistic source and nonlinear production, \begin{equation*} \begin{cases} u_t=\nabla \cdot (D(u) \nabla u) - \nabla \cdot (S(u)\nabla v) + λu - μu^κ, & x\inΩ,\ t>0, \\[1mm] 0=Δv - \overline{M_f}(t) + f(u), & x\inΩ,\ t>0, \end{cases} \end{equation*} where $λ>0$, $μ>0$, $κ>1$ and $\overline{M_f}(t):=\frac{1}{|Ω|}\int_Ω f(u(x,t))\,dx$, and $D$, $S$ and $f$ are functions generalizing the prototypes \begin{align*} D(u)=(u+1)^{m-1},\quad S(u)=u(u+1)^{α-1}\quad\mbox{and}\quad f(u)=u^\ell \end{align*} with $m\in\mathbb{R}$…
Bridging Scales in Chemotaxis: Scale-Uniform Forward Stability for Run-and-Tumble Kernel Estimation
Mathematical Institute, University of Oxford（牛津大学数学研究所）；School of Mathematical Sciences, Institute of Natural Sciences, Shanghai Jiao Tong University（上海交通大学数学科学学院、自然科学研究院）；School of Mathematical Sciences, Institute of Natural Sciences and MOE-LSC, Shanghai Jiao Tong University（上海交通大学数学科学学院、自然科学研究院、教育部线性科学中心）
In this work, we study dynamic properties of classical solutions to a homogenous Neumann initial-boundary value problem (IBVP) for a two-species and two-stimuli chemotaxis model with/without chemical signalling loop in a 2D bounded and smooth domain. We successfully detect the product of two species masses as a feature to determine boundedness, gradient estimates, blow-up and $W^{j,\infty}(1\leq j\leq 3)$-exponential convergence of classical solutions for the corresponding IBVP. More specifically, we first show generally a smallness on the product of both species masses, thus allowing one spec…
This paper deals with the quasilinear degenerate chemotaxis system with flux limitation \begin{equation*} \begin{cases} u_t = \nabla\cdot\left(\dfrac{u^p \nabla u}{\sqrt{u^2 + |\nabla u|^2}} \right) -χ\nabla\cdot\left(\dfrac{u^q\nabla v}{\sqrt{1 + |\nabla v|^2}}\right), \\[1mm] 0 = Δv - μ+ u \end{cases}\end{equation*} under no-flux boundary conditions in balls $Ω\subset\mathbb{R}^n$, and the initial condition $u|_{t=0}=u_0$ for a radially symmetric and positive initial data $u_0\in C^3(\overlineΩ)$, where $χ>0$ and $μ:=\frac{1}{|Ω|}\int_Ωu_0$. Bellomo--Winkler (Comm.\ Partial Differential Equa…
This paper deals with nonnegative solutions of the Neumann initial-boundary value problem for the fully parabolic chemotaxis-growth system $ (u_{\varepsilon})_t$ $=Δu_{\varepsilon} - \varepsilon \nabla \cdot ( u_\varepsilon \nabla v_\varepsilon) + μu_\varepsilon(1 - u_\varepsilon)$, $ (v_{\varepsilon})_t=Δv_\varepsilon -v_\varepsilon+u_\varepsilon,$ with positive small parameter $\varepsilon>0$ in a bounded convex domain $Ω\subset\mathbb{R}^n$ ($n\geq 1$) with smooth boundary. The solutions converge to the solution $u$ to the Fisher-KPP equation as $\varepsilon\to 0$. It is shown that for all …
In this paper we study classical solutions to the zero--flux attraction--repulsion chemotaxis--system \begin{equation}\label{ProblemAbstract} \tag{$\Diamond$} \begin{cases} u_{ t}=Δu -χ\nabla \cdot (u\nabla v)+ξ\nabla \cdot (u\nabla w) & \textrm{in }Ω\times (0,t^*), \\ 0=Δv+αu-βv & \textrm{in } Ω\times (0,t^*),\\ 0=Δw+γu-δw & \textrm{in } Ω\times (0,t^*),\\ \end{cases} \end{equation} where $Ω$ is a smooth and bounded domain of $\mathbb{R}^2$, $t^*$ is the blow--up time and $α,β,γ,δ,χ,ξ$ are positive real numbers. From the literature it is known that under a proper interplay between the above p…
This paper deals with unbounded solutions to the following zero--flux chemotaxis system \begin{equation}\label{ProblemAbstract} \tag{$\Diamond$} \begin{cases} % about u u_t=\nabla \cdot [(u+α)^{m_1-1} \nabla u-χu(u+α)^{m_2-2} \nabla v] & (x,t) \in Ω\times (0,T_{max}), \\[1mm] % about v 0=Δv-M+u & (x,t) \in Ω\times (0,T_{max}), \end{cases} \end{equation} where $α>0$, $Ω$ is a smooth and bounded domain of $\mathbb{R}^n$, with $n\geq 1$, $t\in (0, T_{max})$, where $T_{max}$ the blow-up time, and $m_1,m_2$ real numbers. Given a sufficiently smooth initial data $u_0:=u(x,0)\geq 0$ and set $M:=\frac…
We study the Keller-Segel model of chemotaxis and develop a composite particle-grid numerical method with adaptive time stepping which allows us to accurately resolve singular solutions. The numerical findings (in two dimensions) are then compared with analytical predictions regarding formation and interaction of singularities obtained via analysis of the stochastic differential equations associated with the Keller-Segel model.
