arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2108.02249q-bio.PEcond-mat.stat-mechq-bio.QM
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细胞周期年龄结构多阶段表征的等价框架

An equivalence framework for an age-structured multi-stage representation of the cell cycle

Joshua C. Kynaston, Chris Guiver, Christian A. Yates

摘要:

我们开发的理论等价物之间的随机和确定性模型的人口分层的个人细胞的年龄。具体来说,我们开发了一个分层系统的方程描述的年龄结构的多阶段马尔可夫过程的完整动态近似细胞周期时间分布。我们进一步证明,由此产生的平均行为是等价的,在大的时间尺度上,经典的McKendrick-von Foerster积分偏微分方程。最后,我们将这个框架扩展到空间背景,促进行波现象和细胞介导的图案形成的建模。更一般地说,这种方法可以扩展到无数的反应扩散过程中的个人的年龄是相关的动态。

英文摘要:

We develop theoretical equivalences between stochastic and deterministic models for populations of individual cells stratified by age. Specifically, we develop a hierarchical system of equations describing the full dynamics of an age-structured multi-stage Markov process for approximating cell cycle time distributions. We further demonstrate that the resulting mean behaviour is equivalent, over large timescales, to the classical McKendrick-von Foerster integro-partial differential equation. We conclude by extending this framework to a spatial context, facilitating the modelling of travelling wave phenomena and cell-mediated pattern formation. More generally, this methodology may be extended to myriad reaction-diffusion processes for which the age of individuals is relevant to the dynamics.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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