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arXiv 2602.21150q-bio.PE
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具有疫苗接种的年龄结构传染病模型与媒介传播

Age Structured Epidemic Model under Vaccination with Vector Transmission

NIT Calicut(印度国家技术学院加利卡特分校);Mathematical Institute University of Koblenz(科布伦茨大学数学研究所)

Sourav Banerjee, Thomas Götz, Satyananda Panda

AI总结:

本文研究疫苗接种对登革热长期动态的影响,通过年龄结构模型和疫苗接种时间分析,建立非线性稳态方程并探讨疫病平衡点的唯一性。

摘要:

登革热仍是全球重大公共卫生问题,因其高死亡率和经济负担。数学建模对于理解其传播机制和评估干预策略至关重要。本文提出一个媒介宿主模型,其中人类人口按年龄结构划分,接种者进一步按接种时间描述。蚊虫种群与宿主动态耦合,并在准稳态假设下减少。通过整合疫苗接种年龄,获得非线性稳态方程,并将流行病平衡点表示为感染蚊虫种群的固定点问题。利用Lipschitz估计和收缩论证,在弱传播条件下建立平衡点的存在性和唯一性。分析突显了年龄依赖性疫苗接种对登革热长期动态的影响。

英文摘要:

Dengue remains a major global public health concern due to its high mortality and economic burden. Mathematical modeling is essential to understand its transmission mechanisms and for evaluating intervention strategies. In this paper, we formulate a vector host model in which the human population is structured by age, and vaccinated individuals are further described by time since vaccination. The mosquito population is coupled to the host dynamics and reduced under a quasi steady state assumption. By integrating over vaccination age, we obtain a nonlinear steady state formulation and express the endemic equilibrium as a fixed point problem for the infected mosquito population. Using Lipschitz estimates and a contraction argument, we establish existence and uniqueness of the equilibrium under a weak transmission condition. The analysis highlights the influence of age dependent vaccination on long term dengue dynamics.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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