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arXiv 1609.04136q-bio.PEphysics.bio-phq-bio.GN
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人类基因组中转座子的随机捕食-被捕食动力学

Stochastic predator-prey dynamics of transposons in the human genome

Chi Xue, Nigel Goldenfeld

摘要:

转座因子或转座子是在细胞的生活周期〈动〉<动>中可以在基因组中从一个位点跳到另一个位点的DNA序列,通常编码执行其切除的酶。然而,一些转座子是寄生的,依赖于常规转座子产生的酶。在这种情况下,我们表明,一个随机模型,它考虑到在一个细胞中的转座子的小拷贝数,预测噪声诱导的捕食者-猎物振荡的特征时间尺度,这是远远长于细胞的复制时间,表明状态的捕食者-猎物振荡器存储在基因组中,并传递到连续几代。我们的工作证明了数量波动在移动遗传元件表达中的重要作用,并明确显示了生态学概念如何应用于活基因组的动态和波动。

英文摘要:

Transposable elements, or transposons, are DNA sequences that can jump from site to site in the genome during the life cycle of a cell, usually encoding the very enzymes which perform their excision. However, some transposons are parasitic, relying on the enzymes produced by the regular transposons. In this case, we show that a stochastic model, which takes into account the small copy numbers of the transposons in a cell, predicts noise-induced predator-prey oscillations with a characteristic time scale that is much longer than the cell replication time, indicating that the state of the predator-prey oscillator is stored in the genome and transmitted to successive generations. Our work demonstrates the important role of number fluctuations in the expression of mobile genetic elements, and shows explicitly how ecological concepts can be applied to the dynamics and fluctuations of living genomes.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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