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arXiv 2501.08780cs.LG
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用于时间超分辨率4D Flow MRI的深度学习

Deep learning for temporal super-resolution 4D Flow MRI

Karolinska Institute(卡罗林斯卡学院);University of Michigan(密歇根大学);Telkom University(Telkom大学);University of Auckland(奥克兰大学);Siemens Healthineers AG(西门子医疗健康股份公司);Friedrich-Alexander-Universität Erlangen-Nürnberg(埃尔朗根-纽伦堡弗里德里希-亚历山大大学);King’s College London(伦敦国王学院);Karolinska University Hospital(卡罗林斯卡大学医院);Massachusetts Institute of Technology(麻省理工学院)

Pia Callmer, Mia Bonini, Edward Ferdian, David Nordsletten, Daniel Giese, Alistair A. Young, Alexander Fyrdahl, David Marlevi

AI总结:

本研究针对4D Flow MRI时间分辨率不足的问题,改造4DFlowNet构建时间超分辨率残差网络,经合成与在体数据验证,其性能优于传统插值方法,可在不延长采集时间的前提下实现高帧率血流定量。

摘要:

4D Flow磁共振成像(4D Flow MRI)是一种用于容积式、时间分辨血流定量的无创技术。然而,采集时间、图像噪声与分辨率之间存在明显的权衡关系,限制了其临床应用。尤其是在高瞬态血流区域,粗糙的时间分辨率会阻碍对生理相关血流变化的准确捕捉。为解决这些问题,采用深度学习的后处理技术已展现出可观前景,可通过所谓的超分辨率网络在扫描后提升分辨率。不过,现有超分辨率研究多聚焦于空间上采样,时间超分辨率仍在很大程度上未被探索。因此,本研究的目标是实现并评估一种用于4D Flow MRI时间超分辨率的残差网络。为此,我们对现有的空间网络4DFlowNet进行了重新设计以适配时间上采样,调整了输入维度并优化了内部层结构。研究采用源自患者特异性在体硅模型的合成4D Flow MRI数据以及在体数据集开展训练与测试。总体而言,该网络实现了优异性能,有效对输入速度进行去噪和时间上采样,在未见过的在体硅测试场景中平均绝对误差(MAE)为1.0 cm/s,优于确定性替代方法(线性插值MAE=2.3 cm/s,sinc插值MAE=2.6 cm/s)。此外,该网络能从未见过的低分辨率在体数据中合成高分辨率时间信息,在峰值血流帧处观测到强相关性。综上,我们的结果凸显了将数据驱动的神经网络用于4D Flow MRI时间超分辨率的潜力,可在不将采集时间延长至临床可接受限度之外的前提下实现高帧率血流定量。

英文摘要:

4D Flow Magnetic Resonance Imaging (4D Flow MRI) is a non-invasive technique for volumetric, time-resolved blood flow quantification. However, apparent trade-offs between acquisition time, image noise, and resolution limit clinical applicability. In particular, in regions of highly transient flow, coarse temporal resolution can hinder accurate capture of physiologically relevant flow variations. To overcome these issues, post-processing techniques using deep learning have shown promising results to enhance resolution post-scan using so-called super-resolution networks. However, while super-resolution has been focusing on spatial upsampling, temporal super-resolution remains largely unexplored. The aim of this study was therefore to implement and evaluate a residual network for temporal super-resolution 4D Flow MRI. To achieve this, an existing spatial network (4DFlowNet) was re-designed for temporal upsampling, adapting input dimensions, and optimizing internal layer structures. Training and testing were performed using synthetic 4D Flow MRI data originating from patient-specific in-silico models, as well as using in-vivo datasets. Overall, excellent performance was achieved with input velocities effectively denoised and temporally upsampled, with a mean absolute error (MAE) of 1.0 cm/s in an unseen in-silico setting, outperforming deterministic alternatives (linear interpolation MAE = 2.3 cm/s, sinc interpolation MAE = 2.6 cm/s). Further, the network synthesized high-resolution temporal information from unseen low-resolution in-vivo data, with strong correlation observed at peak flow frames. As such, our results highlight the potential of utilizing data-driven neural networks for temporal super-resolution 4D Flow MRI, enabling high-frame-rate flow quantification without extending acquisition times beyond clinically acceptable limits.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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