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arXiv 2401.04832stat.ME
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针对左截断和区间删失数据的贝叶斯加速失效时间模型的组 lasso 先验

Group lasso priors for Bayesian accelerated failure time models with left-truncated and interval-censored data

Harrison T. Reeder, Sebastien Haneuse, Kyu Ha Lee

AI总结:

本文提出一种带组结构 lasso 惩罚的贝叶斯加速失效时间模型,用于左截断和区间删失数据,通过定制 MCMC 采样器实现变量选择与估计,并在 ROSMAP 队列中识别阿尔茨海默病的预测性遗传和临床风险因素组。

摘要:

健康研究中的一项重要任务是用潜在高维的风险因素集合来刻画事件发生时间结局,例如疾病发病或死亡。例如,阿尔茨海默病的前瞻性队列研究通常会招募老年人进行长达数十年的观察,以评估遗传因素和其他因素对认知衰退和死亡的长期影响。加速失效时间模型特别适用于此类研究,它将协变量效应结构化为生存分位数的“水平”变化,从概念上反映了终身暴露导致的结局分布偏移。然而,这一建模任务因成年人在不同年龄入组以及间歇性随访导致区间删失的结局信息而变得复杂。此外,遗传和临床风险因素不仅具有高维特征,而且具有潜在的分组结构,例如按功能或基因位置分组。对于此类分组的高维协变量,需要能够直接利用该结构的收缩方法来促进变量选择和估计。在本文中,我们通过提出一种具有组结构 lasso 惩罚的贝叶斯加速失效时间模型来直接解决这些问题,该模型专为左截断和区间删失的事件发生时间数据而设计。我们开发了一个定制的马尔可夫链蒙特卡罗采样器以实现高效估计,并研究了不同的惩罚调参和阈值化方法对变量选择的影响。我们呈现了一项模拟研究,考察该方法相对于具有普通 lasso 惩罚模型的表现,并将所提出的方法应用于宗教秩序研究和记忆与衰老项目(ROSMAP)的阿尔茨海默病和痴呆前瞻性队列研究,以识别阿尔茨海默病的预测性遗传和临床风险因素组。

英文摘要:

An important task in health research is to characterize time-to-event outcomes such as disease onset or mortality in terms of a potentially high-dimensional set of risk factors. For example, prospective cohort studies of Alzheimer's disease typically enroll older adults for observation over several decades to assess the long-term impact of genetic and other factors on cognitive decline and mortality. The accelerated failure time model is particularly well-suited to such studies, structuring covariate effects as `horizontal' changes to the survival quantiles that conceptually reflect shifts in the outcome distribution due to lifelong exposures. However, this modeling task is complicated by the enrollment of adults at differing ages, and intermittent followup visits leading to interval censored outcome information. Moreover, genetic and clinical risk factors are not only high-dimensional, but characterized by underlying grouping structure, such as by function or gene location. Such grouped high-dimensional covariates require shrinkage methods that directly acknowledge this structure to facilitate variable selection and estimation. In this paper, we address these considerations directly by proposing a Bayesian accelerated failure time model with a group-structured lasso penalty, designed for left-truncated and interval-censored time-to-event data. We develop a custom Markov chain Monte Carlo sampler for efficient estimation, and investigate the impact of various methods of penalty tuning and thresholding for variable selection. We present a simulation study examining the performance of this method relative to models with an ordinary lasso penalty, and apply the proposed method to identify groups of predictive genetic and clinical risk factors for Alzheimer's disease in the Religious Orders Study and Memory and Aging Project (ROSMAP) prospective cohort studies of AD and dementia.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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