Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the human cornea. Methods: We have developed a high-frequency optical coherence elastography (OCE) technique using shear-like antisymmetric (A0)-mode Lamb waves at frequencies above 10 kHz. Results: By incorporating an anisotropic, nonlinear constitutive model and utilizing the acoustoelastic theory, we gained quantitative insights into the influence of corneal tension on wave speeds and elastic moduli. Our study revealed significant spatial variations in the shear modulus of the corneal stroma on healthy subjects for the first time. The central cornea exhibited a shear modulus of 74 kPa, while the corneal periphery showed a decrease to 41 kPa. The limbus demonstrated an increased shear modulus exceeding 100 kPa. We obtained wave displacement profiles that are consistent with highly anisotropic corneal tissues. Conclusion: Our approach enabled precise measurement of corneal tissue elastic moduli in situ with high precision (< 7%) and high spatial resolution (< 1 mm). Significance: The high-frequency OCE technique holds promise for biomechanical evaluation in clinical settings, providing valuable information for refractive surgeries, degenerative disorder diagnoses, and intraocular pressure assessments.
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
Non-contact acoustic micro-tapping optical coherence elastography for evaluating biomechanical changes in the cornea following UV/riboflavin collagen cross linking: ex vivo human study
In Vivo Quantification of Glioma-Induced Solid Stress Using MR Elastography and Deformable Image Registration
Charité – Universitätsmedizin Berlin（柏林夏里特医科大学）；Berlin Institute of Health at Charité – Universitätsmedizin Berlin（柏林健康研究所（隶属于柏林夏里特医科大学））；Humboldt University, Berlin（柏林洪堡大学）；Physikalisch-Technische Bundesanstalt, Berlin（德国联邦物理技术研究院）；Technical University Berlin, Einstein Center Digital Future（柏林工业大学爱因斯坦数字中心）
Operator-Informed Gaussian Processes for Complex Helmholtz Wavefields: From Synthetic Benchmarks to In Vivo Brain Elastography
Department of Civil and Systems Engineering, Johns Hopkins University（约翰霍普金斯大学土木与系统工程系）；Department of Aerospace Engineering and Mechanics, University of Minnesota（明尼苏达大学航空航天工程与力学系）
Optical time-harmonic elastography for multiscale stiffness mapping across the phylogenetic tree
Charité – Universitätsmedizin Berlin（柏林夏里特医学院）；German Cancer Consortium (DKTK)—German Cancer Research Center (DKFZ)（德国癌症联盟（DKTK）—德国癌症研究中心（DKFZ））；The Hebrew University of Jerusalem（耶路撒冷希伯来大学）；Friedrich-Alexander Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希·亚历山大大学）；Max-Planck-Zentrum für Physik und Medizin（马克斯·普朗克物理与医学中心）；Universidad Técnica Federico Santa María（费德里科·圣玛丽亚技术大学）
Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography
提出结合 OCT 相位去相关与 AμT OCE 及双层模型，在离体人角膜中重建 CXL 后刚度的深度分布并量化手术效果。
Estimation of the surface mechanical properties of soft tissues mimicking phantoms using impact analyses: a comparative study
CNRS, Univ Paris Est Créteil, Univ Gustave Eiffel, UMR 8208, MSME（法国国家科学研究中心，巴黎东克雷泰伊大学，古斯塔夫埃菲尔大学）；Université de technologie de Compiègne, CNRS, BMBI (Biomechanics and Bioengineering)（贡比涅技术大学，法国国家科学研究中心）；Technical University of Munich（慕尼黑工业大学）；Diploma Hochschule（迪普拉玛高等学校）；Ulm University（乌尔姆大学）；Hôpital Henri Mondor AP-HP, CHU Paris 12, Université Paris-Est（亨利·蒙德医院，巴黎十二区大学医院，巴黎东大学）；INSERM U955, IMRB Université Paris-Est（法国国立健康与医学研究院，巴黎东大学）
