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arXiv 2203.16733math.OC
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基于PDE反推的神经元生长输出反馈控制

Neuron Growth Output-Feedback Control by PDE Backstepping

Cenk Demir, Shumon Koga, Miroslav Krstic

摘要:

神经损伤主要导致神经元功能丧失。这些神经元可以在特定的药物治疗后恢复功能,例如软骨素酶ABC(ChABC),其通过操纵细胞外基质、细胞外大分子网络和控制微管蛋白蛋白浓度的矿物质来促进轴突伸长,这是轴突伸长的基础。我们介绍了一个观察员的浓度沿轴突,以及在生长锥,使用测量的轴突长度和微管蛋白通量在生长锥的微管蛋白。我们在边界控制定律中使用该观测器,该定律驱动胞体(核)处的微管蛋白浓度,即,在远离测量位置的轴突末端。对于这个带有移动边界的PDE系统,在空间$\mathcal{H}_1$ -范数下,我们建立了观测器的全局指数收敛性和[axon,observer]系统的局部指数镇定性.结果要求轴突生长速度有界。对于开环观测器,这是通过假设(其要求限制胞体处的微管蛋白流入)来确保的,而对于输出反馈系统,轴突的生长速率通过假设所有状态的初始条件(包括轴突长度)充分接近其设定点值来确保。

英文摘要:

Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the extracellular matrix, the network of extracellular macromolecules, and minerals that control the tubulin protein concentration, which is fundamental to axon elongation. We introduce an observer for the concentration of unmeasured tubulin along the axon, as well as in the growth cone, using the measurement of the axon length and the tubulin flux at the growth cone. We employ this observer in a boundary control law which actuates the tubulin concentration at the soma (nucleus), i.e., at the end of the axon distal from the measurement location. For this PDE system with a moving boundary, coupled with a two-state ODE system, we establish global exponential convergence of the observer and local exponential stabilization of the [axon, observer] system in the spatial $\mathcal{H}_1$-norm. The results require that the axon growth speed be bounded. For an open-loop observer, this is ensured by assumption (which requires that tubulin influx at the soma be limited), whereas for the output-feedback system the growth rate of the axon is ensured by assuming that the initial conditions of all the states, including the axon length, be sufficiently close to their setpoint values.

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