关于SARS-CoV-2病毒Omicron变异体的起源
On the origins of the Omicron variant of the SARS-CoV-2 virus
摘要：
一个可能的解释的基础上出现的Omicron变异的SARS-CoV-2病毒的第一性原理提出涉及与艾滋病毒的共感染。其要点是，由此产生的艾滋病毒诱导的免疫妥协允许SARS-CoV-2更大的自由探索自己的突变空间。这一纬度并非没有限制，并探讨了一个具体的生物物理约束。具体而言，在刺突糖蛋白的蛋白质数据库文件中的亚分子之间观察到骨架氢键的近2 - 5倍差异，从而得出两个结论：刺突的受体结合亚基中的诱变残基更频繁地不参与骨架氢键;因此，病毒逃逸技术是在物理化学和功能限制内去除此类键。早期的工作，从前面的讨论是完全独立的，解释这些现象的自由能，即糖蛋白的亚稳态的一般原则。因此，这些结论可能更普遍地适用于病毒学的原则。
英文摘要：
A possible explanation based on first principles for the appearance of the Omicron variant of the SARS-CoV-2 virus is proposed involving coinfection with HIV. The gist is that the resultant HIV-induced immunocompromise allows SARS-CoV-2 greater latitude to explore its own mutational space. This latitude is not withoutr estriction, and a specific biophysical constraint is explored. Specifically, a nearly two- to five-fold discrepancy in backbone hydrogen bonding is observed between sub-molecules in Protein Data Bank files of the spike glycoprotein yielding two conclusions: mutagenic residues in the receptor-binding subunit of the spike much more frequently do not participate in backbone hydrogen bonds; and a technique of viral escape is therefore to remove such bonds within physico-chemical and functional constraints. Earlier work, from which the previous discussion is entirely independent, explains these phenomena from general principles of free energy, namely, the metastability of the glycoprotein. The conclusions therefore likely hold more generally as principles in virology.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
