选择的人畜共患冠状病毒S基因区的计算机核苷酸和蛋白质分析揭示了保守结构域和进化出现，以及来自SARS-CoV2基因组数据的病毒进入轨迹
In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data
摘要：
最近爆发的新型人畜共患冠状病毒[COVID 19]需要充分了解对人类群体产生不利影响的人畜共患病毒的进化途径，以用于现在和未来对抗大流行病的治疗构建。我们分析了严重急性呼吸道冠状病毒2型（SARS-CoV 2）的保守结构域，以寻找病毒进入宿主细胞抑制的可能靶点，分析了人冠状病毒[229 E]和人畜共患冠状病毒与SARS-CoV 2的进化关系，以及选择的SARS-CoV 2基因组数据之间的进化关系。SARS-CoV 2中对宿主先天抗病毒细胞机制具有拮抗作用的保守结构域包括nsp 11、nsp 13等。此外，选择的候选人畜共患冠状病毒的刺突[S]基因蛋白与SARS-CoV 2的S基因蛋白的多个序列比对显示与穿山甲冠状病毒[S]基因最接近[95.6%]。武汉SARS-CoV 2基因组数据和其他五个数据之间形成的分支表明病毒进入轨迹，同时揭示来自菲律宾的SARS CoV 2基因组和蛋白质数据作为早期祖先。因此，SARS-CoV 2基因组数据的同源性表明，在有和没有爆发的不同人群中，以及迁移历史和种族背景中进行突变跟踪和病毒亚型分歧的日期确定，这对于有效管理当前和未来的人畜共患冠状病毒爆发至关重要。
英文摘要：
The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has necessitated the adequate understanding of the evolutionary pathway of zoonotic viruses which adversely affects human populations for therapeutic constructs to combat the pandemic now and in the future. We analyzed conserved domains of the severe acute respiratory coronavirus 2 [SARS-CoV2] for possible targets of viral entry inhibition in host cells, evolutionary relationship of human coronavirus [229E] and zoonotic coronaviruses with SAR-CoV2 as well as evolutionary relationship between selected SARS-CoV 2 genomic data. Conserved domains with antagonistic action on host innate antiviral cellular mechanisms in SARS-CoV 2 include nsp 11, nsp 13 etc. Also, multiple sequence alignments of the spike [S] gene protein of selected candidate zoonotic coronaviruses alongside the S gene protein of the SARs-CoV2 revealed closest evolutionary relationship [95.6%] with pangolin coronaviruses [S] gene. Clades formed between Wuhan SARS-CoV2 phylogeny data and five others suggests viral entry trajectory while revealing genomic and protein SARS CoV 2 data from Philippines as early ancestors. Therefore, phylogeny of SARS-CoV 2 genomic data suggests profiling in diverse populations with and without the outbreak alongside migration history and racial background for mutation tracking and dating of viral subtype divergence which is essential for effective management of present and future zoonotic coronavirus outbreaks.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
