In this paper, an interpretable classifier using an interval type-2 fuzzy neural network for detecting patients suffering from Parkinson's Disease (PD) based on analyzing the gait cycle is presented. The proposed method utilizes clinical features extracted from the vertical Ground Reaction Force (vGRF), measured by 16 wearable sensors placed in the soles of subjects' shoes and learns interpretable fuzzy rules. Therefore, experts can verify the decision made by the proposed method based on investigating the firing strength of interpretable fuzzy rules. Moreover, experts can utilize the extracted fuzzy rules for patient diagnosing or adjust them based on their knowledge. To improve the robustness of the proposed method against uncertainty and noisy sensor measurements, Interval Type-2 Fuzzy Logic is applied. To learn fuzzy rules, two paradigms are proposed: 1- A batch learning approach based on clustering available samples is applied to extract initial fuzzy rules, 2- A complementary online learning is proposed to improve the rule base encountering new labeled samples. The performance of the method is evaluated for classifying patients and healthy subjects in different conditions including the presence of noise or observing new instances. Moreover, the performance of the model is compared to some previous supervised and unsupervised machine learning approaches. The final Accuracy, Precision, Recall, and F1 Score of the proposed method are 88.74%, 89.41%, 95.10%, and 92.16%. Finally, the extracted fuzzy sets for each feature are reported.
Parkinson's disease (PD) is a non-curable disease that commonly found among elders that greatly reduce their quality of life. PD primarily affects the gait pattern and slowly changes the walking gait from the normality to disability. The early diagnosing of PD is important for treatments and gait pattern analysis is used as a technique to diagnose PD. The present paper has identified the raw spatiotemporal ground reaction force (GRF) as a key parameter to identify the changes in human gait patterns associated with PD. The changes in GRF are identified using a convolutional neural network throu…
This paper focuses on the detection of Parkinson's disease based on the analysis of a patient's gait. The growing popularity and success of Transformer networks in natural language processing and image recognition motivated us to develop a novel method for this problem based on an automatic features extraction via Transformers. The use of Transformers in 1D signal is not really widespread yet, but we show in this paper that they are effective in extracting relevant features from 1D signals. As Transformers require a lot of memory, we decoupled temporal and spatial information to make the model…
Diagnosing Parkinson's disease is a complex task that requires the evaluation of several motor and non-motor symptoms. During diagnosis, gait abnormalities are among the important symptoms that physicians should consider. However, gait evaluation is challenging and relies on the expertise and subjectivity of clinicians. In this context, the use of an intelligent gait analysis algorithm may assist physicians in order to facilitate the diagnosis process. This paper proposes a novel intelligent Parkinson detection system based on deep learning techniques to analyze gait information. We used 1D co…
Parkinson's disease is a neurodegenerative disorder characterized by the presence of different motor impairments. Information from speech, handwriting, and gait signals have been considered to evaluate the neurological state of the patients. On the other hand, user models based on Gaussian mixture models - universal background models (GMM-UBM) and i-vectors are considered the state-of-the-art in biometric applications like speaker verification because they are able to model specific speaker traits. This study introduces the use of GMM-UBM and i-vectors to evaluate the neurological state of Par…
Topological descriptors of foot clearance gait dynamics improve differential diagnosis of Parkinsonism
Centre of Mathematics (CMAT) School of Sciences University of Minho（数学中心（CMAT）科学学院矿产大学）；Neurology Departmet Hospital da Senhora da Oliveira（神经科部门圣奥古斯丁医院）；ICVS School of Medicine University of Minho（ICVS医学院矿产大学）；Algoritmi Centre School of Engineering University of Minho（算法中心工程学院矿产大学）；Centre of Mathematics (CMUP) University of Porto（数学中心（CMUP）波尔图大学）；School and Economics and Management University of Porto（学校和经济管理波尔图大学）
Freezing of gait (FoG) is a common gait disability in Parkinson's disease, that usually appears in its advanced stage. Freeze episodes are associated with falls, injuries, and psychological consequences, negatively affecting the patients' quality of life. For detecting FoG episodes automatically, a highly accurate detection method is necessary. This paper presents an approach for detecting FoG episodes utilizing a deep recurrent neural network (RNN) on 3D-accelerometer measurements. We investigate suitable features and feature combinations extracted from the sensors' time series data. Specific…
Center for Computational Natural Sciences and Bioinformatics, IIIT Hyderabad（海得拉巴国际信息技术学院计算自然科学与生物信息学中心）
Parkinson's Disease (PD) is a chronic and progressive neurological disorder that results in rigidity, tremors and postural instability. There is no definite medical test to diagnose PD and diagnosis is mostly a clinical exercise. Although guidelines exist, about 10-30% of the patients are wrongly diagnosed with PD. Hence, there is a need for an accurate, unbiased and fast method for diagnosis. In this study, we propose LPGNet, a fast and accurate method to diagnose PD from gait. LPGNet uses Linear Prediction Residuals (LPR) to extract discriminating patterns from gait recordings and then uses …
Solarillion Foundation（Solarillion基金会）；SRM Institute of Science and Technology（SRM科学技术学院）
Freezing of Gait (FoG) is a common gait deficit among patients diagnosed with Parkinson's Disease (PD). In order to help these patients recover from FoG episodes, Rhythmic Auditory Stimulation (RAS) is needed. The authors propose a ubiquitous embedded system that detects FOG events with a Machine Learning (ML) subsystem from accelerometer signals . By making inferences on-device, we avoid issues prevalent in cloud-based systems such as latency and network connection dependency. The resource-efficient classifier used, reduces the model size requirements by approximately 400 times compared to th…
Improvement of Performance in Freezing of Gait detection in Parkinsons Disease using Transformer networks and a single waist worn triaxial accelerometer
Universidad Politécnica de Madrid（马德里理工大学）；University of Minho（米尼奥大学）；Politecnico di Torino（都灵理工大学）
The University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）；The University of Texas at Dallas（德克萨斯大学达拉斯分校）
Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim of this study was to develop a model using clinical measures and biomechanical measures of gait and postural stability to predict an individual's PD progression over two years. Data from 160 PD subjects were utilized. Machine learning models, including XGBoost and Feed Forward Neural Networks, were developed using extensive model optimization and cross-vali…
University of Toronto（多伦多大学）；Toronto Rehabilitation Institute, University Health Network（大学健康网络多伦多康复研究所）
This paper presents the design of a wireless sensor network for detecting and alerting the freezing of gait (FoG) symptoms in patients with Parkinson's disease. Three sensor nodes, each integrating a 3-axis accelerometer, can be placed on a patient at ankle, thigh, and truck. Each sensor node can independently detect FoG using an on-device deep learning (DL) model, featuring a squeeze and excitation convolutional neural network (CNN). In a validation using a public dataset, the prototype developed achieved a FoG detection sensitivity of 88.8% and an F1 score of 85.34%, using less than 20 k tra…
Parkinson's disease (PD) is a progressive neurological disorder primarily affecting motor function resulting in tremor at rest, rigidity, bradykinesia, and postural instability. The physical severity of PD impairments can be quantified through the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a widely used clinical rating scale. Accurate and quantitative assessment of disease progression is critical to developing a treatment that slows or stops further advancement of the disease. Prior work has mainly focused on dopamine transport neuroimaging for diagnosis or…
Bi-cephalic self-attended model to classify Parkinson's disease patients with freezing of gait
University of South Dakota（南达科他大学）；LMU University Hospital, Ludwig-Maximilians-Universität München（路德维希-马克西米利安-慕尼黑大学LMU大学医院）；Medical University of South Carolina（南卡罗来纳医科大学）
Deep Learning-Based Estimation of Ground Reaction Forces in Parkinsonian Gait Using an Optimized Set of IMU Data
University of Exeter（埃克塞特大学）；École Polytechnique Fédérale de Lausanne (EPFL)（洛桑联邦理工学院）；University of Cambridge（剑桥大学）；University of Exeter Medical School（埃克塞特大学医学院）；NIHR Exeter BRC（英国国立卫生研究院埃克塞特生物医学研究中心）
School of Arts, Media and Engineering, Arizona State University (ASU)（亚利桑那州立大学艺术、媒体与工程学院）；School of Electrical, Computer and Energy Engineering, ASU（亚利桑那州立大学电气、计算机与能源工程学院）；Edson College of Nursing and Health Innovation, ASU（亚利桑那州立大学埃德森护理与健康创新学院）；College of Health Solutions, ASU（亚利桑那州立大学健康解决方案学院）
Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distrib…
Clinical methods that assess gait in Parkinson's Disease (PD) are mostly qualitative. Quantitative methods necessitate costly instrumentation or cumbersome wearable devices, which limits their usability. Only few of these methods can discriminate different stages in PD progression. This study applies machine learning methods to discriminate six stages of PD. The data was acquired by low cost walker-mounted sensors in an experiment at a movement disorders clinic and the PD stages were clinically labeled. A large set of features, some unique to this study are extracted and three feature selectio…
A Survey of Artificial Intelligence in Gait-Based Neurodegenerative Disease Diagnosis
Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University（南洋理工大学）；College of Computing and Data Science, Nanyang Technological University（南洋理工大学计算机与数据科学学院）
3D image scans are an assessment tool for neurological damage in Parkinson's disease (PD) patients. This diagnosis process can be automatized to help medical staff through Decision Support Systems (DSSs), and Convolutional Neural Networks (CNNs) are good candidates, because they are effective when applied to spatial data. This paper proposes a 3D CNN ordinal model for assessing the level or neurological damage in PD patients. Given that CNNs need large datasets to achieve acceptable performance, a data augmentation method is adapted to work with spatial data. We consider the Ordinal Graph-base…
Interpretable Early Detection of Parkinson's Disease through Speech Analysis
Department of Computer Science, University of Pisa（比萨大学计算机科学系）；School of Public Health, Yale University（耶鲁大学公共卫生学院）；Department of Computer Science, University of Bari（巴里大学计算机科学系）
In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a complete data analysis and during the exploratory phase, we selected a list of differentially expressed genes. Despite their association with the diseased state, we could not use them as a biomarker tool. Therefore, our research was extended to include a multivariate analysis approach resulting in the identification and selection of a group of 20 genes that showed …
Sample-Efficient Reinforcement Learning Controller for Deep Brain Stimulation in Parkinson's Disease
Department of Electrical and Computer Engineering, Clemson University（电子与计算机工程系，克莱姆森大学）；Department of Biomedical Engineering, Michigan Technological University（生物医学工程系，密歇根技术大学）
Brno University of Technology（布尔诺理工大学）；St. Anne’s University Hospital（圣安妮大学医院）；Masaryk University（马萨里克大学）；Escola Universitaria Politecnica de Mataro（马塔罗理工学院）；University of the Basque Country UPV/EHU（巴斯克大学）
Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by conventional clinical interpretable features (jitter, shimmer, harmonic-to-noise ratio, etc.). This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classifi…
Parkinson's disease (PD) is debilitating, progressive, and clinically marked by motor symptoms. As the second most common neurodegenerative disease in the world, it affects over 10 million lives globally. Existing diagnoses methods have limitations, such as the expense of visiting doctors and the challenge of automated early detection, considering that behavioral differences in patients and healthy individuals are often indistinguishable in the early stages. However, micrographia, a handwriting disorder that leads to abnormally small handwriting, tremors, dystonia, and slow movement in the han…
Institute of Robotics and Intelligent Systems（机器人与智能系统研究所）；ETH Zurich（苏黎世联邦理工学院）
Parkinson's disease is a neurodegenerative disease that can affect a person's movement, speech, dexterity, and cognition. Clinicians primarily diagnose Parkinson's disease by performing a clinical assessment of symptoms. However, misdiagnoses are common. One factor that contributes to misdiagnoses is that the symptoms of Parkinson's disease may not be prominent at the time the clinical assessment is performed. Here, we present a machine-learning approach towards distinguishing between people with and without Parkinson's disease using long-term data from smartphone-based walking, voice, tapping…
Parkinson's Disease Detection through Vocal Biomarkers and Advanced Machine Learning Algorithms
New Jersey City University（新泽西城市大学）；University of South Dakota（南达科他大学）；Monroe College（门罗学院）；University of Texas at Dallas（德州大学达拉斯分校）；International American University（国际美国大学）；Gannon University（甘农大学）；Saint Francis College（圣弗朗西斯学院）
Semnan University（塞姆南大学）；Amirkabir University of Technology (Tehran Polytechnic)（阿米尔卡比尔理工大学（德黑兰理工大学））
Background and Objective: Parkinson's disease (PD) is the second most common progressive neurological condition after Alzheimer's, characterized by motor and non-motor symptoms. Developing a method to diagnose the condition in its beginning phases is essential because of the significant number of individuals afflicting with this illness. PD is typically identified using motor symptoms or other Neuroimaging techniques, such as DATSCAN and SPECT. These methods are expensive, time-consuming, and unavailable to the general public; furthermore, they are not very accurate. These constraints encourag…
IBM Hellas（IBM希腊公司）；National Technical University of Athens（雅典国立技术大学）；University of Lincoln（林肯大学）
This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In particular, our approach adopts a combination of transfer learning, k-means clustering and k-Nearest Neighbour classification of deep neural network learned representations to provide enriched prediction of the disease based on MRI and/or DaT Scan data. A new loss function is introduced and used in the training of the DNNs, so as to perform adaptation of the ge…
Weill Cornell Medical College, Cornell University（康奈尔大学威尔康奈尔医学院）
With the arrival of the big data era, more and more data are becoming readily available in various real-world applications and those data are usually highly heterogeneous. Taking computational medicine as an example, we have both Electronic Health Records (EHR) and medical images for each patient. For complicated diseases such as Parkinson's and Alzheimer's, both EHR and neuroimaging information are very important for disease understanding because they contain complementary aspects of the disease. However, EHR and neuroimage are completely different. So far the existing research has been mainl…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degeneration of dopaminergic neurons in the substantia nigra region of the brain. Clinically, dopamine levels are monitored through observing dopamine transporter (DaT) activity. One method of DaT activity analysis is performed with the injection of an Iodine-123 fluoropropyl (123I-FP-C…
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in addition to providing a plausible reason for the prediction. This is kind of reasoning is done through the use of visual indicators generated using Local Interpretable Model-Agnostic Explainer (LIME) methods. DaTscans were drawn from the Parkinson'…
Motor-Imagery based BCI (MI-BCI) neurorehabilitation can improve locomotor ability and reduce the deficit symptoms in Parkinson's Disease patients. Advanced Motor-Imagery BCI methods are needed to overcome the accuracy and time-related MI BCI calibration challenges in such patients. In this study, we proposed a Multi-session FBCSP (msFBCSP) based on inter-session transfer learning and we investigated its performance compared to the single-session based FBSCP. The main result of this study is the significantly improved accuracy obtained by proposed msFBCSP compared to single-session FBCSP in PD…
Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution longitudinal activity data collected by smartphone applications nowadays make it possible to conduct remote and convenient health assessment. However, out-of-lab tests often suffer from poor quality controls as well as irregularly collected observations, leading to noisy test results. To address these issues, we propose a novel time-series based approach to predict…
Azerbaijan State Oil and Industry University（阿塞拜疆石油与工业大学）；Istanbul University Cerrahpasa Faculty of Medicine Hospital（伊斯坦布尔大学切拉帕萨医学院附属医院）
In the world, about 7 to 10 million elderly people are suffering from Parkinson's Disease (PD) disease. Parkinson's disease is a common neurological degenerative disease, and its clinical characteristics are Tremors, rigidity, bradykinesia, and decreased autonomy. Its clinical manifestations are very similar to Multiple System Atrophy (MSA) disorders. Studies have shown that patients with Parkinson's disease often reach an irreparable situation when diagnosed, so As Parkinson's disease can be distinguished from MSA disease and get an early diagnosis, people are constantly exploring new methods…
Edson College of Nursing and Health Innovation, Arizona State University（亚利桑那州立大学埃德森护理与健康创新学院）；School of Arts, Media and Engineering, Arizona State University（亚利桑那州立大学艺术、媒体与工程学院）
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson's disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson's would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing…
