Topological Descriptors for Parkinson's Disease Classification and Regression Analysis
Edson College of Nursing and Health Innovation, Arizona State University（亚利桑那州立大学埃德森护理与健康创新学院）；School of Arts, Media and Engineering, Arizona State University（亚利桑那州立大学艺术、媒体与工程学院）
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson's disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson's would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing Parkinson's disease postural shifts data through the representation of persistence images. Studying the topology of a system has proven to be invariant to small changes in data and has been shown to perform well in discrimination tasks. The contributions of the paper are twofold. We propose a method to 1) classify healthy patients from those afflicted by disease and 2) diagnose the severity of disease. We explore the use of the proposed method in an application involving a Parkinson's disease dataset comprised of healthy-elderly, healthy-young and Parkinson's disease patients. Our code is available at https://github.com/itsmeafra/Sublevel-Set-TDA.
IBM Hellas（IBM希腊公司）；National Technical University of Athens（雅典国立技术大学）；University of Lincoln（林肯大学）
This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In particular, our approach adopts a combination of transfer learning, k-means clustering and k-Nearest Neighbour classification of deep neural network learned representations to provide enriched prediction of the disease based on MRI and/or DaT Scan data. A new loss function is introduced and used in the training of the DNNs, so as to perform adaptation of the ge…
Azerbaijan State Oil and Industry University（阿塞拜疆石油与工业大学）；Istanbul University Cerrahpasa Faculty of Medicine Hospital（伊斯坦布尔大学切拉帕萨医学院附属医院）
In the world, about 7 to 10 million elderly people are suffering from Parkinson's Disease (PD) disease. Parkinson's disease is a common neurological degenerative disease, and its clinical characteristics are Tremors, rigidity, bradykinesia, and decreased autonomy. Its clinical manifestations are very similar to Multiple System Atrophy (MSA) disorders. Studies have shown that patients with Parkinson's disease often reach an irreparable situation when diagnosed, so As Parkinson's disease can be distinguished from MSA disease and get an early diagnosis, people are constantly exploring new methods…
Parkinson's Disease (PD) is a chronic, degenerative disorder which leads to a range of motor and cognitive symptoms. PD diagnosis is a challenging task since its symptoms are very similar to other diseases such as normal ageing and essential tremor. Much research has been applied to diagnosing this disease. This project aims to automate the PD diagnosis process using deep learning, Recursive Neural Networks (RNN) and Convolutional Neural Networks (CNN), to differentiate between healthy and PD patients. Besides that, since different datasets may capture different aspects of this disease, this p…
University of Lincoln（林肯大学）；National Technical University of Athens（雅典国立技术大学）
The paper presents a novel approach, based on deep learning, for diagnosis of Parkinson's disease through medical imaging. The approach includes analysis and use of the knowledge extracted by Deep Convolutional and Recurrent Neural Networks (DNNs) when trained with medical images, such as Magnetic Resonance Images and DaTscans. Internal representations of the trained DNNs constitute the extracted knowledge which is used in a transfer learning and domain adaptation manner, so as to create a unified framework for prediction of Parkinson's across different medical environments. A large experiment…
Parkinson's Disease(PD) is one of the major nervous system disorders that affect people over 60. PD can cause cognitive impairments. In this work, we explore various approaches to identify Parkinson's using Magnetic Resonance (MR) T1 images of the brain. We experiment with ensemble architectures combining some winning Convolutional Neural Network models of ImageNet Large Scale Visual Recognition Challenge (ILSVRC) and propose two architectures. We find that detection accuracy increases drastically when we focus on the Gray Matter (GM) and White Matter (WM) regions from the MR images instead of…
Institute of Robotics and Intelligent Systems（机器人与智能系统研究所）；ETH Zurich（苏黎世联邦理工学院）
Parkinson's disease is a neurodegenerative disease that can affect a person's movement, speech, dexterity, and cognition. Clinicians primarily diagnose Parkinson's disease by performing a clinical assessment of symptoms. However, misdiagnoses are common. One factor that contributes to misdiagnoses is that the symptoms of Parkinson's disease may not be prominent at the time the clinical assessment is performed. Here, we present a machine-learning approach towards distinguishing between people with and without Parkinson's disease using long-term data from smartphone-based walking, voice, tapping…
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in addition to providing a plausible reason for the prediction. This is kind of reasoning is done through the use of visual indicators generated using Local Interpretable Model-Agnostic Explainer (LIME) methods. DaTscans were drawn from the Parkinson'…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degeneration of dopaminergic neurons in the substantia nigra region of the brain. Clinically, dopamine levels are monitored through observing dopamine transporter (DaT) activity. One method of DaT activity analysis is performed with the injection of an Iodine-123 fluoropropyl (123I-FP-C…
Indian Institute of Technology Bhubaneswar（布巴内斯瓦尔印度理工学院）；G.G Vishwavidyalaya, Central University（G.G大学（中央大学））
Parkinson's disease (PD) is one of the major public health problems in the world. It is a well-known fact that around one million people suffer from Parkinson's disease in the United States whereas the number of people suffering from Parkinson's disease worldwide is around 5 million. Thus, it is important to predict Parkinson's disease in early stages so that early plan for the necessary treatment can be made. People are mostly familiar with the motor symptoms of Parkinson's disease, however, an increasing amount of research is being done to predict the Parkinson's disease from non-motor sympt…
In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a complete data analysis and during the exploratory phase, we selected a list of differentially expressed genes. Despite their association with the diseased state, we could not use them as a biomarker tool. Therefore, our research was extended to include a multivariate analysis approach resulting in the identification and selection of a group of 20 genes that showed …
University of Antioquia UdeA（安蒂奥基亚大学）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）
Background and objectives: Parkinson's disease is a neurological disorder that affects the motor system producing lack of coordination, resting tremor, and rigidity. Impairments in handwriting are among the main symptoms of the disease. Handwriting analysis can help in supporting the diagnosis and in monitoring the progress of the disease. This paper aims to evaluate the importance of different groups of features to model handwriting deficits that appear due to Parkinson's disease; and how those features are able to discriminate between Parkinson's disease patients and healthy subjects. Method…
Diagnosing Parkinson's disease is a complex task that requires the evaluation of several motor and non-motor symptoms. During diagnosis, gait abnormalities are among the important symptoms that physicians should consider. However, gait evaluation is challenging and relies on the expertise and subjectivity of clinicians. In this context, the use of an intelligent gait analysis algorithm may assist physicians in order to facilitate the diagnosis process. This paper proposes a novel intelligent Parkinson detection system based on deep learning techniques to analyze gait information. We used 1D co…
Topological descriptors of foot clearance gait dynamics improve differential diagnosis of Parkinsonism
Centre of Mathematics (CMAT) School of Sciences University of Minho（数学中心（CMAT）科学学院矿产大学）；Neurology Departmet Hospital da Senhora da Oliveira（神经科部门圣奥古斯丁医院）；ICVS School of Medicine University of Minho（ICVS医学院矿产大学）；Algoritmi Centre School of Engineering University of Minho（算法中心工程学院矿产大学）；Centre of Mathematics (CMUP) University of Porto（数学中心（CMUP）波尔图大学）；School and Economics and Management University of Porto（学校和经济管理波尔图大学）
Ghent University（根特大学）；Queen Mary University of London（伦敦玛丽女王大学）；Tallinn University of Technology（塔林理工大学）；University of Tartu（塔尔图大学）；Tartu University Hospital（塔尔图大学医院）；Tallinn University（塔林大学）
In recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural network for Parkinson's disease diagnostics, in which a series of hand-drawn data are collected to distinguish Parkinson's disease patients from healthy control subjects. The proposed model consists of a convolution neural network (CNN) cascading to long-short-term memory (LSTM) to adapt the characteristics of collected time-series signals. To make full use of their advantages, a multilayered LSTM model i…
Parkinson's disease is a neurodegenerative disorder characterized by the presence of different motor impairments. Information from speech, handwriting, and gait signals have been considered to evaluate the neurological state of the patients. On the other hand, user models based on Gaussian mixture models - universal background models (GMM-UBM) and i-vectors are considered the state-of-the-art in biometric applications like speaker verification because they are able to model specific speaker traits. This study introduces the use of GMM-UBM and i-vectors to evaluate the neurological state of Par…
Interpretable Early Detection of Parkinson's Disease through Speech Analysis
Department of Computer Science, University of Pisa（比萨大学计算机科学系）；School of Public Health, Yale University（耶鲁大学公共卫生学院）；Department of Computer Science, University of Bari（巴里大学计算机科学系）
Parkinson's disease (PD) is debilitating, progressive, and clinically marked by motor symptoms. As the second most common neurodegenerative disease in the world, it affects over 10 million lives globally. Existing diagnoses methods have limitations, such as the expense of visiting doctors and the challenge of automated early detection, considering that behavioral differences in patients and healthy individuals are often indistinguishable in the early stages. However, micrographia, a handwriting disorder that leads to abnormally small handwriting, tremors, dystonia, and slow movement in the han…
Carnegie Mellon University Africa（卡内基梅隆大学非洲分校）；Carnegie Mellon University（卡内基梅隆大学）；INSOFE（国际工程与科学教育研究所）
One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches to predict PD. Acoustic features such as shimmer and jitter variants, and Mel Frequency Cepstral Coefficients (MFCC) are extracted from speech signals. We use two datasets in this work: the MDVR-KCL and the Italian Parkinson's Voice and Speech database. To separate PD and non-PD speech signals, seven classification models were implemented: K-Nearest Neighbo…
People with Parkinson's disease must be regularly monitored by their physician to observe how the disease is progressing and potentially adjust treatment plans to mitigate the symptoms. Monitoring the progression of the disease through a voice recording captured by the patient at their own home can make the process faster and less stressful. Using a dataset of voice recordings of 42 people with early-stage Parkinson's disease over a time span of 6 months, we applied multiple machine learning techniques to find a correlation between the voice recording and the patient's motor UPDRS score. We ap…
Parkinson's disease (PD) is a slowly progressive debilitating neurodegenerative disease which is prominently characterised by motor symptoms. Indoor localisation, including number and speed of room to room transitions, provides a proxy outcome which represents mobility and could be used as a digital biomarker to quantify how mobility changes as this disease progresses. We use data collected from 10 people with Parkinson's, and 10 controls, each of whom lived for five days in a smart home with various sensors. In order to more effectively localise them indoors, we propose a transformer-based ap…
One major challenge in the medication of Parkinson's disease is that the severity of the disease, reflected in the patients' motor state, cannot be measured using accessible biomarkers. Therefore, we develop and examine a variety of statistical models to detect the motor state of such patients based on sensor data from a wearable device. We find that deep learning models consistently outperform a classical machine learning model applied on hand-crafted features in this time series classification task. Furthermore, our results suggest that treating this problem as a regression instead of an ord…
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which could be well addressed if a personalized medication schedule and dosage could be administered to them. However, such personalized medication schedule requires a continuous, objective and precise measurement of motor symptoms experienced by the patients during their regular daily activities. In this work, we propose the use of a wrist-worn smart-watch, which is…
Parkinson's disease (PD) is a progressive neurological disorder primarily affecting motor function resulting in tremor at rest, rigidity, bradykinesia, and postural instability. The physical severity of PD impairments can be quantified through the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a widely used clinical rating scale. Accurate and quantitative assessment of disease progression is critical to developing a treatment that slows or stops further advancement of the disease. Prior work has mainly focused on dopamine transport neuroimaging for diagnosis or…
Department of Computer Science University of Pisa（比萨大学计算机科学系（更准确的常见译法））
In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during the sketching of spiral tests, without the need for feature extraction and data preprocessing. We evaluated the proposed approach on a public dataset of spiral tests. The results of experimental analysis show that DeepESNs perform significantly better than shallow ESN model. Overall, the proposed approach obtains state-of-the-art results in the identificatio…
Universidad de Antioquia UdeA（安蒂奥基亚大学）；Czech Technical University in Prague（布拉格捷克技术大学）
Parkinson's disease patients develop different speech impairments that affect their communication capabilities. The automatic assessment of the speech of the patients allows the development of computer aided tools to support the diagnosis and the evaluation of the disease severity. This paper introduces a methodology to classify Parkinson's disease from speech in three different languages: Spanish, German, and Czech. The proposed approach considers convolutional neural networks trained with time frequency representations and a transfer learning strategy among the three languages. The transfer …
This paper focuses on the detection of Parkinson's disease based on the analysis of a patient's gait. The growing popularity and success of Transformer networks in natural language processing and image recognition motivated us to develop a novel method for this problem based on an automatic features extraction via Transformers. The use of Transformers in 1D signal is not really widespread yet, but we show in this paper that they are effective in extracting relevant features from 1D signals. As Transformers require a lot of memory, we decoupled temporal and spatial information to make the model…
Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function alterations. Functional magnetic resonance imaging (fMRI) is a promising tool in revealing functional connectivity (FC) differences and developing biomarkers in PD. Some machine learning approaches like support vector machine and logistic regression have been successfully applied in the early diagnosis of PD using fMRI data, which outperform classifiers based on manual…
Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution longitudinal activity data collected by smartphone applications nowadays make it possible to conduct remote and convenient health assessment. However, out-of-lab tests often suffer from poor quality controls as well as irregularly collected observations, leading to noisy test results. To address these issues, we propose a novel time-series based approach to predict…
Accurate and early prediction of a disease allows to plan and improve a patient's quality of future life. During pandemic situations, the medical decision becomes a speed challenge in which physicians have to act fast to diagnose and predict the risk of the severity of the disease, moreover this is also of high priority for neurodegenerative diseases like Parkinson's disease. Machine Learning (ML) models with Features Selection (FS) techniques can be applied to help physicians to quickly diagnose a disease. FS optimally subset features that improve a model performance and help reduce the numbe…
University of Southern California（南加州大学）；Chang Gung Memorial Hospital（长庚纪念医院）；University of Pennsylvania Perelman School of Medicine（宾夕法尼亚大学佩雷尔曼医学院）；Chang Gung University（长庚大学）；Amsterdam UMC, Vrije Universiteit Amsterdam（阿姆斯特丹大学医学中心，阿姆斯特丹自由大学）
There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early stages. Here we leverage severity-based meta-data on the stages of disease to define a curriculum for training a deep convolutional neural network (CNN). Typically, deep learning networks are trained by randomly selecting samples in each mini-batch. By contrast, curriculum learning is a training strategy that aims to boost classifier performance by starting wi…
Cloud Computing Research Center（云计算研究中心）；National Sun Yat-sen University（国立中山大学）；National Institute of Technology（国家理工学院）
In this modern era of overpopulation disease prediction is a crucial step in diagnosing various diseases at an early stage. With the advancement of various machine learning algorithms, the prediction has become quite easy. However, the complex and the selection of an optimal machine learning technique for the given dataset greatly affects the accuracy of the model. A large amount of datasets exists globally but there is no effective use of it due to its unstructured format. Hence, a lot of different techniques are available to extract something useful for the real world to implement. Therefore…
University of Münster（明斯特大学）；Klinikum Osnabrück（奥斯纳布吕克医院）
Sensors from smart consumer devices have demonstrated high potential to serve as digital biomarkers in the identification of movement disorders in recent years. With the usage of broadly available smartwatches we have recorded participants performing technology-based assessments in a prospective study to research Parkinson's Disease (PD). In total, 504 participants, including PD patients, differential diagnoses (DD) and healthy controls (HC), were captured with a comprehensive system utilizing two smartwatches and two smartphones. To the best of our knowledge, this study provided the largest P…
Ludwig-Maximilians-Universität München（慕尼黑大学）；Technical University of Munich（慕尼黑工业大学）；Schön Klinik München Schwabing（慕尼黑施瓦宾 Schön 诊所）；University of Waterloo（滑铁卢大学）
The assessment of Parkinson's disease (PD) poses a significant challenge as it is influenced by various factors which lead to a complex and fluctuating symptom manifestation. Thus, a frequent and objective PD assessment is highly valuable for effective health management of people with Parkinson's disease (PwP). Here, we propose a method for monitoring PwP by stochastically modeling the relationships between their wrist movements during unscripted daily activities and corresponding annotations about clinical displays of movement abnormalities. We approach the estimation of PD motor signs by ind…
The University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）；The University of Texas at Dallas（德克萨斯大学达拉斯分校）
Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim of this study was to develop a model using clinical measures and biomechanical measures of gait and postural stability to predict an individual's PD progression over two years. Data from 160 PD subjects were utilized. Machine learning models, including XGBoost and Feed Forward Neural Networks, were developed using extensive model optimization and cross-vali…
University of Münster（明斯特大学）；Klinikum Osnabrück（奥斯纳布吕克医院）
In recent years, sensors from smart consumer devices have shown great diagnostic potential in movement disorders. In this context, data modalities such as electronic questionnaires, hand movement and voice captures have successfully captured biomarkers and allowed discrimination between Parkinson's disease (PD) and healthy controls (HC) or differential diagnosis (DD). However, to the best of our knowledge, a comprehensive evaluation of assessments with a multi-modal smart device system has still been lacking. In a prospective study exploring PD, we used smartwatches and smartphones to collect …
Motor-Imagery based BCI (MI-BCI) neurorehabilitation can improve locomotor ability and reduce the deficit symptoms in Parkinson's Disease patients. Advanced Motor-Imagery BCI methods are needed to overcome the accuracy and time-related MI BCI calibration challenges in such patients. In this study, we proposed a Multi-session FBCSP (msFBCSP) based on inter-session transfer learning and we investigated its performance compared to the single-session based FBSCP. The main result of this study is the significantly improved accuracy obtained by proposed msFBCSP compared to single-session FBCSP in PD…
SAFE-D: A Spatiotemporal Detection Framework for Abnormal Driving Among Parkinson's Disease-like Drivers
Hong Kong JC STEM Lab of Smart City and Department of Computer Science, City University of Hong Kong（香港JC STEM实验室及城市大学计算机科学系）；Department of Computer Science and Engineering, Hong Kong University of Science and Technology（香港理工大学计算机科学与工程系）；Department of Electrical and Electronic Engineering, The University of Hong Kong（香港大学电子与电气工程系）
Modeling Parkinson's Disease Progression Using Longitudinal Voice Biomarkers: A Comparative Study of Statistical and Neural Mixed-Effects Models
Department of Mathematical Sciences（数学科学系）；Naveen Jindal School of Management（奈文·金达管理学院）；Department of Biology（生物系）；University of Texas at Dallas（德克萨斯大学达拉斯分校）；Duke University（杜克大学）；The Second Affiliated Hospital, Zhejiang University School of Medicine（浙江大学医学院第二附属医院）；Department of Neurosurgery（神经外科系）
Parkinson's Disease Detection through Vocal Biomarkers and Advanced Machine Learning Algorithms
New Jersey City University（新泽西城市大学）；University of South Dakota（南达科他大学）；Monroe College（门罗学院）；University of Texas at Dallas（德州大学达拉斯分校）；International American University（国际美国大学）；Gannon University（甘农大学）；Saint Francis College（圣弗朗西斯学院）
Brno University of Technology（布尔诺理工大学）；St. Anne’s University Hospital（圣安妮大学医院）；Masaryk University（马萨里克大学）；Escola Universitaria Politecnica de Mataro（马塔罗理工学院）；University of the Basque Country UPV/EHU（巴斯克大学）
Up to 90% of patients with Parkinson's disease (PD) suffer from hypokinetic dysathria (HD) which is also manifested in the field of phonation. Clinical signs of HD like monoloudness, monopitch or hoarse voice are usually quantified by conventional clinical interpretable features (jitter, shimmer, harmonic-to-noise ratio, etc.). This paper provides large and robust insight into perceptual analysis of 5 Czech vowels of 84 PD patients and proves that despite the clinical inexplicability the perceptual features outperform the conventional ones, especially in terms of discrimination power (classifi…
