DaTscan SPECT Image Classification for Parkinson's Disease

An Explainable Machine Learning Model for Early Detection of Parkinson's Disease using LIME on DaTscan Imagery

Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in addition to providing a plausible reason for the prediction. This is kind of reasoning is done through the use of visual indicators generated using Local Interpretable Model-Agnostic Explainer (LIME) methods. DaTscans were drawn from the Parkinson'…

Self-normalized Classification of Parkinson's Disease DaTscan Images

Classifying SPECT images requires a preprocessing step which normalizes the images using a normalization region. The choice of the normalization region is not standard, and using different normalization regions introduces normalization region-dependent variability. This paper mathematically analyzes the effect of the normalization region to show that normalized-classification is exactly equivalent to a subspace separation of the half rays of the images under multiplicative equivalence. Using this geometry, a new self-normalized classification strategy is proposed. This strategy eliminates the …

Dopamine Transporter SPECT Image Classification for Neurodegenerative Parkinsonism via Diffusion Maps and Machine Learning Classifiers

Neurodegenerative parkinsonism can be assessed by dopamine transporter single photon emission computed tomography (DaT-SPECT). Although generating images is time consuming, these images can show interobserver variability and they have been visually interpreted by nuclear medicine physicians to date. Accordingly, this study aims to provide an automatic and robust method based on Diffusion Maps and machine learning classifiers to classify the SPECT images into two types, namely Normal and Abnormal DaT-SPECT image groups. In the proposed method, the 3D images of N patients are mapped to an N by N…

Disease-oriented image embedding with pseudo-scanner standardization for content-based image retrieval on 3D brain MRI

To build a robust and practical content-based image retrieval (CBIR) system that is applicable to a clinical brain MRI database, we propose a new framework -- Disease-oriented image embedding with pseudo-scanner standardization (DI-PSS) -- that consists of two core techniques, data harmonization and a dimension reduction algorithm. Our DI-PSS uses skull stripping and CycleGAN-based image transformations that map to a standard brain followed by transformation into a brain image taken with a given reference scanner. Then, our 3D convolutioinal autoencoders (3D-CAE) with deep metric learning acqu…

通过卷积神经网络从SPECT成像中准确早期检测帕金森病

Accurate early detection of Parkinson's disease from SPECT imaging through Convolutional Neural Networks

本研究利用SPECT图像特征开发机器学习模型，以高准确性早期区分帕金森病、SWEDD与正常受试者，助力临床诊断。

Parkinson's Disease Recognition Using SPECT Image and Interpretable AI: A Tutorial

In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results in difficult model interpretation when used in clinical. Even though there are multiple interpretation methods available for the DL model, there is no evidence of which method is suitable for PD recognition application. This tutorial aims to demonstrate the procedure to choose a suitable interpretation method for the PD recognition model. We exhibit four DC…