In the world, about 7 to 10 million elderly people are suffering from Parkinson's Disease (PD) disease. Parkinson's disease is a common neurological degenerative disease, and its clinical characteristics are Tremors, rigidity, bradykinesia, and decreased autonomy. Its clinical manifestations are very similar to Multiple System Atrophy (MSA) disorders. Studies have shown that patients with Parkinson's disease often reach an irreparable situation when diagnosed, so As Parkinson's disease can be distinguished from MSA disease and get an early diagnosis, people are constantly exploring new methods. With the advent of the era of big data, deep learning has made major breakthroughs in image recognition and classification. Therefore, this study proposes to use The deep learning method to realize the diagnosis of Parkinson's disease, multiple system atrophy, and healthy people. This data source is from Istanbul University Cerrahpasa Faculty of Medicine Hospital. The processing of the original magnetic resonance image (Magnetic Resonance Image, MRI) is guided by the doctor of Istanbul University Cerrahpasa Faculty of Medicine Hospital. The focus of this experiment is to improve the existing neural network so that it can obtain good results in medical image recognition and diagnosis. An improved algorithm was proposed based on the pathological characteristics of Parkinson's disease, and good experimental results were obtained by comparing indicators such as model loss and accuracy.
Interpretable machine learning predicts Parkinson's disease severity using motion-corrected QSM MRI and multiband multiecho fMRI features
Lyda Hill Department of Bioinformatics（Lyda Hill 生物信息学系）；Department of Biomedical Engineering（生物医学工程系）；University of Texas Southwestern Medical Center, Dallas, Texas, USA（德克萨斯西南医学中心，德克萨斯州达拉斯）
In this work, we use a deep learning framework for simultaneous classification and regression of Parkinson disease diagnosis based on MR-Images and personal information (i.e. age, gender). We intend to facilitate and increase the confidence in Parkinson disease diagnosis through our deep learning framework.
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in addition to providing a plausible reason for the prediction. This is kind of reasoning is done through the use of visual indicators generated using Local Interpretable Model-Agnostic Explainer (LIME) methods. DaTscans were drawn from the Parkinson'…
Diagnosing Parkinson's disease is a complex task that requires the evaluation of several motor and non-motor symptoms. During diagnosis, gait abnormalities are among the important symptoms that physicians should consider. However, gait evaluation is challenging and relies on the expertise and subjectivity of clinicians. In this context, the use of an intelligent gait analysis algorithm may assist physicians in order to facilitate the diagnosis process. This paper proposes a novel intelligent Parkinson detection system based on deep learning techniques to analyze gait information. We used 1D co…
Classifying SPECT images requires a preprocessing step which normalizes the images using a normalization region. The choice of the normalization region is not standard, and using different normalization regions introduces normalization region-dependent variability. This paper mathematically analyzes the effect of the normalization region to show that normalized-classification is exactly equivalent to a subspace separation of the half rays of the images under multiplicative equivalence. Using this geometry, a new self-normalized classification strategy is proposed. This strategy eliminates the …
Parkinson's disease (PD) is a progressive neurological disorder primarily affecting motor function resulting in tremor at rest, rigidity, bradykinesia, and postural instability. The physical severity of PD impairments can be quantified through the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a widely used clinical rating scale. Accurate and quantitative assessment of disease progression is critical to developing a treatment that slows or stops further advancement of the disease. Prior work has mainly focused on dopamine transport neuroimaging for diagnosis or…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degeneration of dopaminergic neurons in the substantia nigra region of the brain. Clinically, dopamine levels are monitored through observing dopamine transporter (DaT) activity. One method of DaT activity analysis is performed with the injection of an Iodine-123 fluoropropyl (123I-FP-C…
In this work, we explore various neural network architectures using Magnetic Resonance (MR) T1 images of the brain to identify Parkinson's Disease (PD), which is one of the most common neurodegenerative and movement disorders. We propose three ensemble architectures combining some winning Convolutional Neural Network models of ImageNet Large Scale Visual Recognition Challenge (ILSVRC). All of our proposed architectures outperform existing approaches to detect PD from MR images, achieving upto 95\% detection accuracy. We also find that when we construct our ensemble architecture using models pr…
Weill Cornell Medical College, Cornell University（康奈尔大学威尔康奈尔医学院）；University of Connecticut（康涅狄格大学）；Feinberg School of Medicine, Northwestern University（西北大学范伯格医学院）；Michigan State University（密歇根州立大学）
Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive or disease progression modeling of PD using clinical and biomarkers data. Neuroimaging, as another important information source for neurodegenerative disease, has also arisen considerable interests from the PD community. In this paper, we propose a deep learning method based on Graph Convolutional Networks (GCN) for fusing multiple modalities of brain images …
Parkinson's Disease (PD) is one of the most common types of neurological diseases caused by progressive degeneration of dopamin- ergic neurons in the brain. Even though there is no fixed cure for this neurodegenerative disease, earlier diagnosis followed by earlier treatment can help patients have a better quality of life. Magnetic Resonance Imag- ing (MRI) has been one of the most popular diagnostic tool in recent years because it avoids harmful radiations. In this paper, we investi- gate the plausibility of using MRIs for automatically diagnosing PD. Our proposed method has three main steps …
AI WALKUP: A Computer-Vision Approach to Quantifying MDS-UPDRS in Parkinson's Disease
Key Lab of Image Processing and Intelligent Control, Ministry of Education（教育部图像处理与智能控制重点实验室）；School of Artificial Intelligence and Automation（人工智能与自动化学院）；Huazhong University of Science and Technology（华中科技大学）
Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in a variety of motor dysfunction symptoms, including tremors, bradykinesia, rigidity and postural instability. The diagnosis of PD mainly relies on clinical experience rather than a definite medical test, and the diagnostic accuracy is only about 73-84% since it is challenged by the subjective opinions or experiences of different medical experts. Therefore, an efficient and interpretable automatic PD diagnosis system is valuable for supporting clinicians with more robust diagnostic decision-making. To this end, …
Brno University of Technology（布尔诺理工大学）；Masaryk University（马萨里克大学）；Escola Universitaria Politecnica de Mataro（马塔罗理工学院）
In this paper, we evaluate the contribution of different handwriting modalities to the diagnosis of Parkinson's disease. We analyse on-surface movement, in-air movement and pressure exerted on the tablet surface. Especially in-air movement and pressure-based features have been rarely taken into account in previous studies. We show that pressure and in-air movement also possess information that is relevant for the diagnosis of Parkinson's Disease (PD) from handwriting. In addition to the conventional kinematic and spatio-temporal features, we present a group of the novel features based on entro…
University of Waterloo（滑铁卢大学）；Ludwig-Maximilians-Univ. München（慕尼黑大学）；Technical University of Munich（慕尼黑工业大学）；Schön Klinik München Schwabing（慕尼黑施瓦宾 Schön 医院）
While convolutional neural networks (CNNs) have been successfully applied to many challenging classification applications, they typically require large datasets for training. When the availability of labeled data is limited, data augmentation is a critical preprocessing step for CNNs. However, data augmentation for wearable sensor data has not been deeply investigated yet. In this paper, various data augmentation methods for wearable sensor data are proposed. The proposed methods and CNNs are applied to the classification of the motor state of Parkinson's Disease patients, which is challenging…
University of Southern California（南加州大学）；Chang Gung Memorial Hospital（长庚纪念医院）；University of Pennsylvania Perelman School of Medicine（宾夕法尼亚大学佩雷尔曼医学院）；Chang Gung University（长庚大学）；Amsterdam UMC, Vrije Universiteit Amsterdam（阿姆斯特丹大学医学中心，阿姆斯特丹自由大学）
There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early stages. Here we leverage severity-based meta-data on the stages of disease to define a curriculum for training a deep convolutional neural network (CNN). Typically, deep learning networks are trained by randomly selecting samples in each mini-batch. By contrast, curriculum learning is a training strategy that aims to boost classifier performance by starting wi…
KITE — Toronto Rehabilitation Institute — University Health Network（凯特大西洋康复研究所——多伦多康复研究所——大学医疗网络）；University of Toronto（多伦多大学）；Sunnybrook Research Institute（森尼布鲁克研究所）
Orofacial deficits are common in people with Parkinson's disease (PD) and their evolution might represent an important biomarker of disease progression. We are developing an automated system for assessment of orofacial function in PD that can be used in-home or in-clinic and can provide useful and objective clinical information that informs disease management. Our current approach relies on color and depth cameras for the estimation of 3D facial movements. However, depth cameras are not commonly available, might be expensive, and require specialized software for control and data processing. Th…
Universidad del Atlántico Medio（中大西洋大学）；Bahria University（巴哈里亚大学）；University of Bari “Aldo Moro”（巴里大学“阿尔多·莫罗”）
Parkinson's disease (PD) is commonly characterized by several motor symptoms, such as bradykinesia, akinesia, rigidity, and tremor. The analysis of patients' fine motor control, particularly handwriting, is a powerful tool to support PD assessment. Over the years, various dynamic attributes of handwriting, such as pen pressure, stroke speed, in-air time, etc., which can be captured with the help of online handwriting acquisition tools, have been evaluated for the identification of PD. Motion events, and their associated spatio-temporal properties captured in online handwriting, enable effectiv…
University of Waterloo（滑铁卢大学）；Ludwig-Maximilians University（路德维希-马克西米利安大学）；Technical University of Munich（慕尼黑工业大学）；Schön Klinik München Schwabing（慕尼黑施瓦宾 Schön 诊所）
Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms, however, side-effects may include uncontrolled movements, known as dyskinesia. In this paper, an automatic PD motor-state assessment in free-living conditions is proposed using an accelerometer in a wrist-worn wearable sensor. In particular, an ensemble of convolutional neural networks (CNNs) is applied to capture the large variability of daily-living activities …
IBM Research Australia（IBM研究院澳大利亚分院）；IBM Research Yorktown Heights（IBM研究院约克镇高地分院）
This paper presents a novel deep learning enabled, video based analysis framework for assessing the Unified Parkinsons Disease Rating Scale (UPDRS) that can be used in the clinic or at home. We report results from comparing the performance of the framework to that of trained clinicians on a population of 32 Parkinsons disease (PD) patients. In-person clinical assessments by trained neurologists are used as the ground truth for training our framework and for comparing the performance. We find that the standard sit-to-stand activity can be used to evaluate the UPDRS sub-scores of bradykinesia (B…
Universidad Católica de Oriente（东方天主教大学）；Universidad de Antioquia（安蒂奥基亚大学）；Universidad Autónoma de Madrid（马德里自治大学）
In this paper we evaluate the suitability of handwriting patterns as potential biomarkers to model Parkinson disease (PD). Although the study of PD is attracting the interest of many researchers around the world, databases to evaluate handwriting patterns are scarce and knowledge about patterns associated to PD is limited and biased to the existing datasets. This paper introduces a database with a total of 935 handwriting tasks collected from 55 PD patients and 94 healthy controls (45 young and 49 old). Three feature sets are extracted from the signals: neuromotor, kinematic, and nonlinear dyn…
From Visual Attribution to Clinical Reasoning: Explainable Parkinson's Disease Screening from Hand-Drawn Patterns
Indian Institute of Technology Indore（印度理工学院印多尔分校）；Indian Institute of Technology Patna（印度理工学院巴特那分校）；M. R. Bangur Hospital（M. R. 班古尔医院）；University of Western Australia（西澳大利亚大学）
Interpretable and Granular Video-Based Quantification of Motor Characteristics from the Finger Tapping Test in Parkinson Disease
Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center（神经科、帕金森病和运动障碍专家中心、大脑、认知与行为研究所、拉德堡德大学医学中心）；Department of Artificial Intelligence, Donders Institute for Brain, Cognition and Behaviour, Radboud University（人工智能系、大脑、认知与行为研究所、拉德堡德大学）
