Freezing of gait (FoG) is a common gait disability in Parkinson's disease, that usually appears in its advanced stage. Freeze episodes are associated with falls, injuries, and psychological consequences, negatively affecting the patients' quality of life. For detecting FoG episodes automatically, a highly accurate detection method is necessary. This paper presents an approach for detecting FoG episodes utilizing a deep recurrent neural network (RNN) on 3D-accelerometer measurements. We investigate suitable features and feature combinations extracted from the sensors' time series data. Specifically, for detecting FoG episodes, we apply a deep RNN with Long Short-Term Memory cells. In our experiments, we perform both user dependent and user independent experiments, to detect freeze episodes. Our experimental results show that the frequency domain features extracted from the trunk sensor are the most informative feature group in the subject independent method, achieving an average AUC score of 93%, Specificity of 90% and Sensitivity of 81%. Moreover, frequency and statistical features of all the sensors are identified as the best single input for the subject dependent method, achieving an average AUC score of 97%, Specificity of 96% and Sensitivity of 87%. Overall, in a comparison to state-of-the-art approaches from literature as baseline methods, our proposed approach outperforms these significantly.
Topological descriptors of foot clearance gait dynamics improve differential diagnosis of Parkinsonism
Centre of Mathematics (CMAT) School of Sciences University of Minho（数学中心（CMAT）科学学院矿产大学）；Neurology Departmet Hospital da Senhora da Oliveira（神经科部门圣奥古斯丁医院）；ICVS School of Medicine University of Minho（ICVS医学院矿产大学）；Algoritmi Centre School of Engineering University of Minho（算法中心工程学院矿产大学）；Centre of Mathematics (CMUP) University of Porto（数学中心（CMUP）波尔图大学）；School and Economics and Management University of Porto（学校和经济管理波尔图大学）
Parkinson's disease (PD) is a non-curable disease that commonly found among elders that greatly reduce their quality of life. PD primarily affects the gait pattern and slowly changes the walking gait from the normality to disability. The early diagnosing of PD is important for treatments and gait pattern analysis is used as a technique to diagnose PD. The present paper has identified the raw spatiotemporal ground reaction force (GRF) as a key parameter to identify the changes in human gait patterns associated with PD. The changes in GRF are identified using a convolutional neural network throu…
Parkinson's disease is a common neurological disease, entailing a multitude of motor deficiency symptoms. In this project, we developed a device with an uploaded edge machine learning algorithm that can detect the onset of freezing of gait symptoms in a Parkinson's patient. The algorithm achieved an accuracy of 83.7% in a validation using data from ten patients. The model was deployed in a microcontroller Arduino Nano 33 BLE Sense Board model and validated in real-time operation with data streamed to the microcontroller from a computer.
Solarillion Foundation（Solarillion基金会）；SRM Institute of Science and Technology（SRM科学技术学院）
Freezing of Gait (FoG) is a common gait deficit among patients diagnosed with Parkinson's Disease (PD). In order to help these patients recover from FoG episodes, Rhythmic Auditory Stimulation (RAS) is needed. The authors propose a ubiquitous embedded system that detects FOG events with a Machine Learning (ML) subsystem from accelerometer signals . By making inferences on-device, we avoid issues prevalent in cloud-based systems such as latency and network connection dependency. The resource-efficient classifier used, reduces the model size requirements by approximately 400 times compared to th…
University of Toronto（多伦多大学）；Toronto Rehabilitation Institute, University Health Network（大学健康网络多伦多康复研究所）
This paper presents the design of a wireless sensor network for detecting and alerting the freezing of gait (FoG) symptoms in patients with Parkinson's disease. Three sensor nodes, each integrating a 3-axis accelerometer, can be placed on a patient at ankle, thigh, and truck. Each sensor node can independently detect FoG using an on-device deep learning (DL) model, featuring a squeeze and excitation convolutional neural network (CNN). In a validation using a public dataset, the prototype developed achieved a FoG detection sensitivity of 88.8% and an F1 score of 85.34%, using less than 20 k tra…
The University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）；The University of Texas at Dallas（德克萨斯大学达拉斯分校）
Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim of this study was to develop a model using clinical measures and biomechanical measures of gait and postural stability to predict an individual's PD progression over two years. Data from 160 PD subjects were utilized. Machine learning models, including XGBoost and Feed Forward Neural Networks, were developed using extensive model optimization and cross-vali…
Improvement of Performance in Freezing of Gait detection in Parkinsons Disease using Transformer networks and a single waist worn triaxial accelerometer
Universidad Politécnica de Madrid（马德里理工大学）；University of Minho（米尼奥大学）；Politecnico di Torino（都灵理工大学）
Detecting Daily Living Gait Amid Huntington's Disease Chorea using a Foundation Deep Learning Model
Tel Aviv University（特拉维夫大学）；Tel Aviv Sourasky Medical Center（特拉维夫苏拉斯基医疗中心）；Teachers College, Columbia University（哥伦比亚大学教师学院）；Wayne State University（韦恩州立大学）；Stony Brook University（石溪大学）；Rush University Medical Center（拉什大学医学中心）
The accurate and reliable detection or prediction of freezing of gaits (FOG) is important for fall prevention in Parkinson's Disease (PD) and studying the physiological transitions during the occurrence of FOG. Integrating both commercial and self-designed sensors, a protocal has been designed to acquire multimodal physical and physiological information during FOG, including gait acceleration (ACC), electroencephalogram (EEG), electromyogram (EMG), and skin conductance (SC). Two tasks were designed to trigger FOG, including gait initiation failure and FOG during walking. A total number of 12 P…
Deep Learning-Based Estimation of Ground Reaction Forces in Parkinsonian Gait Using an Optimized Set of IMU Data
University of Exeter（埃克塞特大学）；École Polytechnique Fédérale de Lausanne (EPFL)（洛桑联邦理工学院）；University of Cambridge（剑桥大学）；University of Exeter Medical School（埃克塞特大学医学院）；NIHR Exeter BRC（英国国立卫生研究院埃克塞特生物医学研究中心）
Freezing-of-gait a mysterious symptom of Parkinsons disease and defined as a sudden loss of ability to move forward. Common treatments of freezing episodes are currently of moderate efficacy and can likely be improved through a reliable freezing evaluation. Basic-science studies about the characterization of freezing episodes and a 24/7 evidence-support freezing detection system can contribute to the reliability of the evaluation in daily life. In this study, we analyzed multi-modal features from brain, eye, heart, motion, and gait activity from 15 participants with idiopathic Parkinsons disea…
Mobility is severely impacted in patients with Parkinson's disease (PD), especially when they experience involuntary stopping from the freezing of gait (FOG). Understanding the neurophysiological difference between "voluntary stopping" and "involuntary stopping" caused by FOG is vital for the detection and potential intervention of FOG in the daily lives of patients. This study characterised the electroencephalographic (EEG) signature associated with FOG in contrast to voluntary stopping. The protocol consisted of a timed up-and-go (TUG) task and an additional TUG task with a voluntary stoppin…
Clinical methods that assess gait in Parkinson's Disease (PD) are mostly qualitative. Quantitative methods necessitate costly instrumentation or cumbersome wearable devices, which limits their usability. Only few of these methods can discriminate different stages in PD progression. This study applies machine learning methods to discriminate six stages of PD. The data was acquired by low cost walker-mounted sensors in an experiment at a movement disorders clinic and the PD stages were clinically labeled. A large set of features, some unique to this study are extracted and three feature selectio…
Freezing of Gait Detection Using Gramian Angular Fields and Federated Learning from Wearable Sensors
College of Health Solutions, Arizona State University（亚利桑那州立大学健康解决方案学院）；Bangladesh University of Engineering and Technology（孟加拉国工程与技术大学）；Khulna University of Engineering and Technology（库尔纳工程与技术大学）；School of Computing and Augmented Intelligence, Arizona State University（亚利桑那州立大学计算与增强智能学院）
Movement disorders, such as Parkinson's disease, affect more than 10 million people worldwide. Gait analysis is a critical step in the diagnosis and rehabilitation of these disorders. Specifically, step length provides valuable insights into the gait quality and rehabilitation process. However, traditional approaches for estimating step length are not suitable for continuous daily monitoring since they rely on special mats and clinical environments. To address this limitation, we present a novel and practical step-length estimation technique using low-power wearable bend and inertial sensors. …
Passive monitoring in daily life may provide invaluable insights about a person's health throughout the day. Wearable sensor devices are likely to play a key role in enabling such monitoring in a non-obtrusive fashion. However, sensor data collected in daily life reflects multiple health and behavior related factors together. This creates the need for structured principled analysis to produce reliable and interpretable predictions that can be used to support clinical diagnosis and treatment. In this work we develop a principled modelling approach for free-living gait (walking) analysis. Gait i…
Over the years motor deficit in Parkinson's Disease (PD) patients was largely studied, however, no consistent pattern of relations between quantitative electroencephalography (qEEG) and motor scales emerged. There is a general lack of information on the relation between EEG changes and scales related to specific motor deficits. Therefore, the study aimed to investigate the relation between brain oscillatory activity alterations (EEG power bands) and most used PD-related motor deficit scales. A positive correlation was found between the freezing of the gait questionnaire (FOGQ) and delta spectr…
University of Padova（帕多瓦大学）；National Centre of Neurology and Psychiatry (NCNP)（国立精神·神经医疗研究中心）；Newcastle University（纽卡斯尔大学）；Newcastle upon Tyne Hospitals NHS Foundation Trust（纽卡斯尔医院NHS基金会信托）
Wearable technology for the automatic detection of gait events has recently gained growing interest, enabling advanced analyses that were previously limited to specialist centres and equipment (e.g., instrumented walkway). In this study, we present a novel method based on dilated convolutions for an accurate detection of gait events (initial and final foot contacts) from wearable inertial sensors. A rich dataset has been used to validate the method, featuring 71 people with Parkinson's disease (PD) and 67 healthy control subjects. Multiple sensors have been considered, one located on the fifth…
Deep brain stimulation (DBS) has shown great promise toward treating motor symptoms caused by Parkinson's disease (PD), by delivering electrical pulses to the Basal Ganglia (BG) region of the brain. However, DBS devices approved by the U.S. Food and Drug Administration (FDA) can only deliver continuous DBS (cDBS) stimuli at a fixed amplitude; this energy inefficient operation reduces battery lifetime of the device, cannot adapt treatment dynamically for activity, and may cause significant side-effects (e.g., gait impairment). In this work, we introduce an offline reinforcement learning (RL) fr…
