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arXiv 2104.08595stat.ME
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分位数回归的混合效应建模与变量选择

Mixed Effect Modeling and Variable Selection for Quantile Regression

Haim Bar, James Booth, Martin T. Wells

摘要:

已知分位数回归(QR)的估计方程可以使用期望最大化算法求解,其中M步通过加权最小二乘法计算,在E步处计算的权重作为独立广义逆高斯变量的期望。这里利用这一事实来扩展QR,以允许线性预测器中的随机效应。在这种设置的算法的收敛性建立表明,它是一个广义交替最小化(GAM)的过程。另一个修改的期望最大化算法也允许我们适应最近提出的方法,平均回归模型中的变量选择的QR设置。仿真结果表明,所得到的方法显着优于使用套索惩罚的QR模型中的变量选择。应用到实际数据包括住院时间的脆弱QR分析,以及使用高维基因表达阵列预测肺癌发病年龄和核黄素生产率的变量选择。

英文摘要:

It is known that the estimating equations for quantile regression (QR) can be solved using an EM algorithm in which the M-step is computed via weighted least squares, with weights computed at the E-step as the expectation of independent generalized inverse-Gaussian variables. This fact is exploited here to extend QR to allow for random effects in the linear predictor. Convergence of the algorithm in this setting is established by showing that it is a generalized alternating minimization (GAM) procedure. Another modification of the EM algorithm also allows us to adapt a recently proposed method for variable selection in mean regression models to the QR setting. Simulations show the resulting method significantly outperforms variable selection in QR models using the lasso penalty. Applications to real data include a frailty QR analysis of hospital stays, and variable selection for age at onset of lung cancer and for riboflavin production rate using high-dimensional gene expression arrays for prediction.

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