We consider the problem of nonparametric quantile regression for twice censored data. Two new estimates are presented, which are constructed by applying concepts of monotone rearrangements to estimates of the conditional distribution function. The proposed methods avoid the problem of crossing quantile curves. Weak uniform consistency and weak convergence is established for both estimates and their finite sample properties are investigated by means of a simulation study. As a by-product, we obtain a new result regarding the weak convergence of the Beran estimator for right censored data on the maximal possible domain, which is of its own interest.
When facing multivariate covariates, general semiparametric regression techniques come at hand to propose flexible models that are unexposed to the curse of dimensionality. In this work a semiparametric copula-based estimator for conditional quantiles is investigated for complete or right-censored data. In spirit, the methodology is extending the recent work of Noh et al. (2013) and Noh et al. (2015), as the main idea consists in appropriately defining the quantile regression in terms of a multivariate copula and marginal distributions. Prior estimation of the latter and simple plug-in lead to…
With the availability of high dimensional genetic biomarkers, it is of interest to identify heterogeneous effects of these predictors on patients' survival, along with proper statistical inference. Censored quantile regression has emerged as a powerful tool for detecting heterogeneous effects of covariates on survival outcomes. To our knowledge, there is little work available to draw inference on the effects of high dimensional predictors for censored quantile regression. This paper proposes a novel procedure to draw inference on all predictors within the framework of global censored quantile …
Department of Mathematics University of California San Diego（加利福尼亚大学圣地亚哥分校数学系）
Random forests are powerful non-parametric regression method but are severely limited in their usage in the presence of randomly censored observations, and naively applied can exhibit poor predictive performance due to the incurred biases. Based on a local adaptive representation of random forests, we develop its regression adjustment for randomly censored regression quantile models. Regression adjustment is based on new estimating equations that adapt to censoring and lead to quantile score whenever the data do not exhibit censoring. The proposed procedure named censored quantile regression f…
We consider quantile regression processes from censored data under dependent data structures and derive a uniform Bahadur representation for those processes. We also consider cases where the dimension of the parameter in the quantile regression model is large. It is demonstrated that traditional penalized estimators such as the adaptive lasso yield sub-optimal rates if the coefficients of the quantile regression cross zero. New penalization techniques are introduced which are able to deal with specific problems of censored data and yield estimates with an optimal rate. In contrast to most of t…
In many applications, heterogeneous treatment effects on a censored response variable are of primary interest, and it is natural to evaluate the effects at different quantiles (e.g., median). The large number of potential effect modifiers, the unknown structure of the treatment effects, and the presence of right censoring pose significant challenges. In this paper, we develop a hybrid forest approach called Hybrid Censored Quantile Regression Forest (HCQRF) to assess the heterogeneous effects varying with high-dimensional variables. The hybrid estimation approach takes advantage of the random …
This paper proposes a new test for the comparison of conditional quantile curves when the outcome of interest, typically a duration, is subject to right censoring. The test can be applied both in the case of two independent samples and for paired data, and can be used for the comparison of quantiles at a fixed quantile level, a finite set of levels or a range of quantile levels. The asymptotic distribution of the proposed test statistics is obtained both under the null hypothesis and under local alternatives. We describe a bootstrap procedure in order to approximate the critical values, and pr…
In this paper, we study a novel approach for the estimation of quantiles when facing potential right censoring of the responses. Contrary to the existing literature on the subject, the adopted strategy of this paper is to tackle censoring at the very level of the loss function usually employed for the computation of quantiles, the so-called "check" function. For interpretation purposes, a simple comparison with the latter reveals how censoring is accounted for in the newly proposed loss function. Subsequently, when considering the inclusion of covariates for conditional quantile estimation, by…
This paper, investigates the conditional quantile estimation of a scalar random response and a functional random covariate (i.e. valued in some infinite-dimensional space) whenever {\it functional stationary ergodic data with random censorship} are considered. We introduce a kernel type estimator of the conditional quantile function. We establish the strong consistency with rate of this estimator as well as the asymptotic normality which induces a confidence interval that is usable in practice since it does not depend on any unknown quantity. An application to electricity peak demand interval …
University of California San Diego（加州大学圣地亚哥分校）；Alexa AI（Alexa人工智能部门）
Random forests are powerful non-parametric regression method but are severely limited in their usage in the presence of randomly censored observations, and naively applied can exhibit poor predictive performance due to the incurred biases. Based on a local adaptive representation of random forests, we develop its regression adjustment for randomly censored regression quantile models. Regression adjustment is based on a new estimating equation that adapts to censoring and leads to quantile score whenever the data do not exhibit censoring. The proposed procedure named {\it censored quantile regr…
We propose a censored quantile regression estimator motivated by unbiased estimating equations. Under the usual conditional independence assumption of the survival time and the censoring time given the covariates, we show that the proposed estimator is consistent and asymptotically normal. We develop an efficient computational algorithm which uses existing quantile regression code. As a result, bootstrap-type inference can be efficiently implemented. We illustrate the finite-sample performance of the proposed method by simulation studies and analysis of a survival data set.
Tsinghua University（清华大学）；Microsoft Research（微软研究院）；University of Pittsburgh（匹兹堡大学）
This paper considers doing quantile regression on censored data using neural networks (NNs). This adds to the survival analysis toolkit by allowing direct prediction of the target variable, along with a distribution-free characterisation of uncertainty, using a flexible function approximator. We begin by showing how an algorithm popular in linear models can be applied to NNs. However, the resulting procedure is inefficient, requiring sequential optimisation of an individual NN at each desired quantile. Our major contribution is a novel algorithm that simultaneously optimises a grid of quantile…
Outlying observations, which significantly deviate from other measurements, may distort the conclusions of data analysis. Therefore, identifying outliers is one of the important problems that should be solved to obtain reliable results. While there are many statistical outlier detection algorithms and software programs for uncensored data, few are available for censored data. In this article, we propose three outlier detection algorithms based on censored quantile regression, two of which are modified versions of existing algorithms for uncensored or censored data, while the third is a newly d…
In this paper, we develop a new censored quantile instrumental variable (CQIV) estimator and describe its properties and computation. The CQIV estimator combines Powell (1986) censored quantile regression (CQR) to deal with censoring, with a control variable approach to incorporate endogenous regressors. The CQIV estimator is obtained in two stages that are non-additive in the unobservables. The first stage estimates a non-additive model with infinite dimensional parameters for the control variable, such as a quantile or distribution regression model. The second stage estimates a non-additive …
Censored quantile regression (CQR) has become a valuable tool to study the heterogeneous association between a possibly censored outcome and a set of covariates, yet computation and statistical inference for CQR have remained a challenge for large-scale data with many covariates. In this paper, we focus on a smoothed martingale-based sequential estimating equations approach, to which scalable gradient-based algorithms can be applied. Theoretically, we provide a unified analysis of the smoothed sequential estimator and its penalized counterpart in increasing dimensions. When the covariate dimen…
Thus far, likelihood-based interval estimates for quantiles have not been studied in the literature on interval censored case 2 data and partly interval censored data, and, in this context, the use of smoothing has not been considered for any type of censored data. This article constructs smoothed weighted empirical likelihood ratio confidence intervals (WELRCI) for quantiles in a unified framework for various types of censored data, including right censored data, doubly censored data, interval censored data and partly interval censored data. The fourth order expansion of the weighted empirica…
Quantile regression has been advocated in survival analysis to assess evolving covariate effects. However, challenges arise when the censoring time is not always observed and may be covariate-dependent, particularly in the presence of continuously-distributed covariates. In spite of several recent advances, existing methods either involve algorithmic complications or impose a probability grid. The former leads to difficulties in the implementation and asymptotics, whereas the latter introduces undesirable grid dependence. To resolve these issues, we develop fundamental and general quantile cal…
We develop inference procedures for longitudinal data where some of the measurements are censored by fixed constants. We consider a semi-parametric quantile regression model that makes no distributional assumptions. Our research is motivated by the lack of proper inference procedures for data from biomedical studies where measurements are censored due to a fixed quantification limit. In such studies the focus is often on testing hypotheses about treatment equality. To this end, we propose a rank score test for large sample inference on a subset of the covariates. We demonstrate the importance …
We consider a regression modeling of the quantiles of residual life, remaining lifetime at a specific time. We propose a smoothed induced version of the existing non-smooth estimating equations approaches for estimating regression parameters. The proposed estimating equations are smooth in regression parameters, so solutions can be readily obtained via standard numerical algorithms. Moreover, the smoothness in the proposed estimating equations enables one to obtain a robust sandwich-type covariance estimator of regression estimators aided by an efficient resampling method. To handle data subje…
The computational prediction algorithm of neural network, or deep learning, has drawn much attention recently in statistics as well as in image recognition and natural language processing. Particularly in statistical application for censored survival data, the loss function used for optimization has been mainly based on the partial likelihood from Cox's model and its variations to utilize existing neural network library such as Keras, which was built upon the open source library of TensorFlow. This paper presents a novel application of the neural network to the quantile regression for survival…
The classic censored regression model (tobit model) has been widely used in the economic literature. This model assumes normality for the error distribution and is not recommended for cases where positive skewness is present. Moreover, in regression analysis, it is well-known that a quantile regression approach allows us to study the influences of the explanatory variables on the dependent variable considering different quantiles. Therefore, we propose in this paper a quantile tobit regression model based on quantile-based log-symmetric distributions. The proposed methodology allows us to mode…
A flexible quantile mixed-effects model for censored outcomes
Syneos Health；Department of Mathematical Statistics and Actuarial Science, University of the Free State（自由州大学数学统计与精算科学系）；I-BioStat, KU Leuven（KU鲁汶大学生物统计研究所）；Department of Statistics and Actuarial Science, University of Stellenbosch（斯泰伦博斯大学统计与精算科学系）
$\ell_1$-penalized quantile regression is widely used for analyzing high-dimensional data with heterogeneity. It is now recognized that the $\ell_1$-penalty introduces non-negligible estimation bias, while a proper use of concave regularization may lead to estimators with refined convergence rates and oracle properties as the signal strengthens. Although folded concave penalized $M$-estimation with strongly convex loss functions have been well studied, the extant literature on quantile regression is relatively silent. The main difficulty is that the quantile loss is piecewise linear: it is non…
Quantile regression is a powerful tool for learning the relationship between a response variable and a multivariate predictor while exploring heterogeneous effects. In this paper, we consider statistical inference for quantile regression with large-scale data in the "increasing dimension" regime. We provide a comprehensive and in-depth analysis of a convolution-type smoothing approach that achieves adequate approximation to computation and inference for quantile regression. This method, which we refer to as {\it{conquer}}, turns the non-differentiable quantile loss function into a twice-differ…
In this work we show a Bayesian quantile regression method to response variables with mixed discrete-continuous distribution with a point mass at zero, where these observations are believed to be left censored or true zeros. We combine the information provided by the quantile regression analysis to present a more complete description of the probability of being censored given that the observed value is equal to zero, while also studying the conditional quantiles of the continuous part. We build up an Markov Chain Monte Carlo method from related models in the literature to obtain samples from t…
In this paper, nonparametric estimation of the conditional Weibull-tail coefficient when the variable of interest is right random censored is addressed. A Weissman-type estimator of conditional extreme quantile is also proposed. In addition, a simulation study is conducted to assess the finite-sample behavior of the proposed estimators and a comparison with alternative strategies is provided. Finally, the practical applicability of the methodology is presented using a real datasets of men suffering from a larynx cancer.
Here we develop a method for performing nonparametric Bayesian inference on quantiles. Relying on geometric measure theory and employing a Hausdorff base measure, we are able to specify meaningful priors for the quantile while treating the distribution of the data otherwise nonparametrically. We further extend the method to a hierarchical model for quantiles of subpopulations, linking subgroups together solely through their quantiles. Our approach is computationally straightforward, allowing for censored and noisy data. We demonstrate the proposed methodology on simulated data and an applied p…
Estimating Distributions with Failure Rate Properties from Noisy Quantile Data
Department of Mechanical and Industrial Engineering, University of Toronto（多伦多大学机械与工业工程系）；Rotman School of Management, University of Toronto（多伦多大学罗特曼管理学院）；The Wharton School, University of Pennsylvania（宾夕法尼亚大学沃顿商学院）
We study tail estimation in Pareto-like settings for datasets with a high percentage of randomly right-censored data, and where some expert information on the tail index is available for the censored observations. This setting arises for instance naturally for liability insurance claims, where actuarial experts build reserves based on the specificity of each open claim, which can be used to improve the estimation based on the already available data points from closed claims. Through an entropy-perturbed likelihood we derive an explicit estimator and establish a close analogy with Bayesian meth…
In survey analysis, the estimation of the cumulative distribution function (cdf) is of great interest: it allows for instance to derive quantiles estimators or other non linear parameters derived from the cdf. We consider the case where the response variable is a right censored duration variable. In this framework, the classical estimator of the cdf is the Kaplan-Meier estimator. As an alternative, we propose a nonparametric model-based estimator of the cdf in a finite population. The new estimator uses auxiliary information brought by a continuous covariate and is based on nonparametric media…
In this paper we survey and unify a large class or $L$-functionals of the conditional distribution of the response variable in regression models. This includes robust measures of location, scale, skewness, and heavytailedness of the response, conditionally on covariates. We generalize the concepts of $L$-moments (Sittinen, 1969), $L$-skewness, and $L$-kurtosis (Hosking, 1990) and introduce order numbers for a large class of $L$-functionals through orthogonal series expansions of quantile functions. In particular, we motivate why location, scale, skewness, and heavytailedness have order numbers…
Nonparametric and semiparametric methods are commonly used in survival analysis to mitigate the bias due to model misspecification. However, such methods often cannot estimate upper-tail survival quantiles when a sizable proportion of the data are censored, in which case parametric likelihood-based estimators present a viable alternative. In this article, we extend a popular family of parametric survival models which make the Accelerated Failure Time (AFT) assumption to account for heteroscedasticity in the survival times. The conditional variances can depend on arbitrary covariates, thus addi…
We consider estimation of the extreme value index and extreme quantiles for heavy-tailed data that are right-censored. We study a general procedure of removing low importance observations in tail estimators. This trimming procedure is applied to the state-of-the-art estimators for randomly right-censored tail estimators. Through an averaging procedure over the amount of trimming we derive new kernel type estimators. Extensive simulation suggests that one of the new considered kernels leads to a highly competitive estimator against virtually any other available alternative in this framework. Mo…
In a unified framework, we provide estimators and confidence bands for a variety of treatment effects when the outcome of interest, typically a duration, is subjected to right censoring. Our methodology accommodates average, distributional, and quantile treatment effects under different identifying assumptions including unconfoundedness, local treatment effects, and nonlinear differences-in-differences. The proposed estimators are easy to implement, have close-form representation, are fully data-driven upon estimation of nuisance parameters, and do not rely on parametric distributional assumpt…
This paper develops a general theory on rates of convergence of penalized spline estimators for function estimation when the likelihood functional is concave in candidate functions, where the likelihood is interpreted in a broad sense that includes conditional likelihood, quasi-likelihood, and pseudo-likelihood. The theory allows all feasible combinations of the spline degree, the penalty order, and the smoothness of the unknown functions. According to this theory, the asymptotic behaviors of the penalized spline estimators depends on interplay between the spline knot number and the penalty pa…
This paper studies the identification and estimation of weighted average derivatives of conditional location functionals including conditional mean and conditional quantiles in settings where either the outcome variable or a regressor is interval-valued. Building on Manski and Tamer (2002) who study nonparametric bounds for mean regression with interval data, we characterize the identified set of weighted average derivatives of regression functions. Since the weighted average derivatives do not rely on parametric specifications for the regression functions, the identified set is well-defined w…
It is challenging to deal with censored data, where we only have access to the incomplete information of survival time instead of its exact value. Fortunately, under linear predictor assumption, people can obtain guaranteed coverage for the confidence band of survival time using methods like Cox Regression. However, when relaxing the linear assumption with neural networks (e.g., Cox-MLP (Katzman et al., 2018; Kvamme et al., 2019)), we lose the guaranteed coverage. To recover the guaranteed coverage without linear assumption, we propose two algorithms based on conformal inference. In the first …
Residuals in normal regression are used to assess a model's goodness-of-fit (GOF) and discover directions for improving the model. However, there is a lack of residuals with a characterized reference distribution for censored regression. In this paper, we propose to diagnose censored regression with normalized randomized survival probabilities (RSP). The key idea of RSP is to replace the survival probability of a censored failure time with a uniform random number between 0 and the survival probability of the censored time. We prove that RSPs always have the uniform distribution on $(0,1)$ unde…
The estimation of extreme flood quantiles is challenging due to the relative scarcity of extreme data compared to typical target return periods. Several approaches have been developed over the years to face this challenge, including regional estimation and the use of historical flood data. This paper investigates the combination of both approaches using a multivariate peaks-over-threshold model, that allows estimating altogether the intersite dependence structure and the marginal distributions at each site. The joint distribution of extremes at several sites is constructed using a semi-paramet…
This paper studies computationally and theoretically attractive estimators called the Laplace type estimators (LTE), which include means and quantiles of Quasi-posterior distributions defined as transformations of general (non-likelihood-based) statistical criterion functions, such as those in GMM, nonlinear IV, empirical likelihood, and minimum distance methods. The approach generates an alternative to classical extremum estimation and also falls outside the parametric Bayesian approach. For example, it offers a new attractive estimation method for such important semi-parametric problems as c…
Modern Statistical Models and Methods for Estimating Fatigue-Life and Fatigue-Strength Distributions from Experimental Data
Iowa State University（爱荷华州立大学）；Louisiana State University（路易斯安那州立大学）；Washington State University（华盛顿州立大学）；Virginia Tech（弗吉尼亚理工大学）；JMP Statistical Discovery LLC（JMP统计发现有限责任公司）；U.S. Food and Drug Administration（美国食品药品监督管理局）；Honda Aero（本田航空）
