arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2103.09886physics.bio-phcond-mat.softcond-mat.stat-mech
收藏

活性液滴中的分子组装线

Molecular Assembly Lines in Active Droplets

Tyler S. Harmon, Frank Jülicher

摘要:

大的蛋白质复合物由蛋白质亚基组装而成,形成特定的结构。在我们的理论工作中,我们提出,组装成正确的结构可以可靠地实现通过装配线与特定序列的装配步骤。使用液滴接口定位隔室边界,我们表明,装配线可以自组织的活性液滴。因此,组装步骤可以在空间上布置,使得实现特定的组装顺序,并且强烈抑制不正确的组装。

英文摘要:

Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific sequence of assembly steps. Using droplet interfaces to position compartment boundaries, we show that an assembly line can be self organized by active droplets. As a consequence, assembly steps can be arranged spatially so that a specific order of assembly is achieved and incorrect assembly is strongly suppressed.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑