AI 中文总结
研究生物分子凝聚物相关问题，通过发展具有非马尔可夫反应的活性相分离理论，揭示延迟反应反馈对液滴状态的影响，以及在多液滴系统中的作用，确立反应记忆为控制参数，关联多种细胞行为。
AI 中文摘要
生物分子凝聚物通过生化反应不断重塑，可展现非马尔可夫、历史依赖动力学。我们发展了具有非马尔可夫反应的活性相分离理论，表明延迟反应反馈会使静止液滴不稳定。当记忆时间与反应周转时间可比时，凝聚物变形并自发获得极性、自推进状态。在多液滴系统中，持久记忆尾流介导排列，产生极性聚集体，在更高浓度下产生移动迷宫。这些结果将反应记忆确立为活性相分离的控制参数，连接凝聚物重塑、自主运动性和集体组织，并提示细胞内类聚集行为的可能途径。
英文摘要
Biomolecular condensates are continually remodeled by biochemical reactions that can exhibit non-Markovian, history-dependent dynamics. We develop a theory of active phase separation with non-Markovian reactions and show that delayed reaction feedback destabilizes stationary droplets: when the memory time becomes comparable to the reaction turnover time, condensates deform and spontaneously acquire a polar, self-propelled state. In multidroplet systems, persistent memory wakes mediate alignment, producing polar flocks and, at higher concentrations, traveling labyrinths. These results establish reaction memory as a control parameter of active phase separation, linking condensate remodeling, autonomous motility, and collective organization, and suggest a possible route to flocking-like behavior within cells.
