We have further extended our compartmental model describing the spread of the infection in Italy. The model is based on the assumption that the time evolution of all of the observable quantities (number of people still positive to the infection, hospitalized and fatalities cases, healed people, and total number of people that has contracted the infection) depend on average parameters, namely people diffusion coefficient, infection cross-section, and population density. The model provides precious information on the tight relationship between the variation of the reported infection cases and a well defined observable physical quantity: the average number of people that lie within the daily displacement area of any single person. The extension of the model now includes self-consistent evaluation of the reproduction index, effect of immunization due to vaccination, and potential impact of virus variants on the dynamical evolution of the outbreak. The model fits very well the epidemic data, and allows us to strictly relate the time evolution of the number of hospitalized case and fatalities to the change of people mobility, vaccination rate, and appearance of an initial concentration of people positives for new variants of the virus.
Most countries have started vaccinating people against COVID-19. However, due to limited production capacities and logistical challenges it will take months/years until herd immunity is achieved. Therefore, vaccination and social distancing have to be coordinated. In this paper, we provide some insight on this topic using optimization-based control on an age-differentiated compartmental model. For real-life decision making, we investigate the impact of the planning horizon on the optimal vaccination/social distancing strategy. We find that in order to reduce social distancing in the long run, …
How to prevent the spread of human diseases is a great challenge for the scientific community and so far there are many studies in which immunization strategies have been developed. However, these kind of strategies usually do not consider that medical institutes may have limited vaccine resources available. In this manuscript, we explore the Susceptible-Infected-Recovered (SIR) model with local dynamic vaccination, and considering limited vaccines. In this model, susceptibles in contact with an infected individual, are vaccinated -with probability $ω$- and then get infected -with probability …
This paper is concerned with the analysis of vaccination strategies in a stochastic SIR (susceptible $\to$ infected $\to$ removed) model for the spread of an epidemic amongst a population of individuals with a random network of social contacts that is also partitioned into households. Under various vaccine action models, we consider both household-based vaccination schemes, in which the way in which individuals are chosen for vaccination depends on the size of the households in which they reside, and acquaintance vaccination, which targets individuals of high degree in the social network. For …
We analyse the data for the global corona virus (COVID-19) outbreak using the results of a previously studied Susceptible-Infected-Removed (SIR) model of epidemic spreading on Euclidean networks. We also directly study the correlation of the distance from the epicenter and the number of cases. An inverse square law is seen to exist approximately. The studies are made for China and the rest of the world separately.
By the end of 2020, a year since the first cases of infection by the Covid-19 virus have been reported, there is a light at the end of the tunnel. Several pharmaceutical companies made significant progress in developing effective vaccines against the Covid-19 virus that has claimed the lives of more than a million people over the world. On the other hand, there is growing evidence of re-infection by the virus, which can cause further outbreaks. In this paper, we apply statistical physics tools to examine the vaccination rate required to control the pandemic for three different vaccine efficien…
The mitigation of an infectious disease spreading has recently gained considerable attention from the research community. It may be obtained by adopting sanitary measurements social rules, together with an extensive vaccination campaign. Vaccination is currently the primary way for mitigating the Coronavirus Disease (COVID-19) outbreak without severe lockdown. Its effectiveness also depends on the number and timeliness of administrations and thus demands strict prioritization criteria. Almost all countries have prioritized similar classes of exposed workers obtaining to maximize the survival o…
We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network. We analyze a networked version of the Susceptible-Infected-Susceptible (SIS) epidemic model when individuals in the network present different levels of susceptibility to the epidemic. In this context, controlling the spread of an epidemic outbreak can be written as a spectral condition involving the eigenvalues of a matrix that depends on the network structure and the parameters of the model. We study the problem of finding…
Opposition to vaccination has long been a non-negligible public health phenomenon resulted from people's varied perceptions toward vaccination (e.g., vaccine-phobia). This paper investigates the voluntary vaccination behavior of a heterogeneous population during an epidemic outbreak, where each individual makes its own vaccination decision to minimize its expected disutility from both vaccine-phobia and the risk of infection. Such a problem is known as a vaccination game, as people's vaccination decisions not only affect their own disutilities but those of all others through probabilistic dise…
Vaccination and outbreak monitoring are essential tools for preventing and minimizing outbreaks of infectious diseases. Targeted strategies, where the individuals most important for monitoring or preventing outbreaks are selected for intervention, offer a possibility to significantly improve these measures. Although targeted strategies carry a strong potential, identifying optimal target groups remains a challenge. Here we consider the problem of identifying target groups based on digital communication networks (telecommunication, online social media) in order to predict and contain an infecti…
The 6th wave of COVID-19 in Tokyo continued for the longest period of infection (about 190 days from late Nov. 2021), and the 7th wave, which occurred in mid-May 2022, was the largest wave ever (cumulative 1.7 million people). In order to elucidate their factors, the infection wave was analyzed by using the Avrami equation. The main component of the 6th wave was formed by the coupling of increased human interaction due to the New Year holidays and the invasion of the new virus variant Omicron BA.1. After that, side waves were formed by the coupling of the invasion of the new virus variant Omic…
The slogan "nobody is safe until everybody is safe" is a dictum to raise awareness that in an interconnected world, pandemics such as COVID-19, require a global approach. Motivated by the ongoing COVID-19 pandemic, we model here the spread of a virus in interconnected communities and explore different vaccination scenarios, assuming that the efficacy of the vaccination wanes over time. We start with susceptible populations and consider a susceptible-vaccinated-infected-recovered model with unvaccinated ("Bronze"), moderately vaccinated ("Silver") and very well vaccinated ("Gold") communities, …
When modelling epidemics or spread of information on online social networks, it is crucial to include not just the density of the connections through which infections can be transmitted, but also the variability of susceptibility. Different people have different chance to be infected by a disease (due to age or general health conditions), or, in case of opinions, ones are easier to be convinced by others, or stronger at sharing their opinions. The goal of this work is to examine the effect of multiple types of nodes on various random graphs such as Erdős--Rényi random graphs, preferential atta…
At the moment of writing (12 February, 2020), the future evolution of the 2019-nCoV virus is unclear. Predictions of the further course of the epidemic are decisive to deploy targeted disease control measures. We consider a network-based model to describe the 2019-nCoV epidemic in the Hubei province. The network is composed of the cities in Hubei and their interactions (e.g., traffic flow). However, the precise interactions between cities is unknown and must be inferred from observing the epidemic. We propose a network-based method to predict the future prevalence of the 2019-nCoV virus in eve…
At the end of 2020, policy responses to the SARS-CoV-2 outbreak have been shaken by the emergence of virus variants. The emergence of these more contagious, more severe, or even vaccine-resistant strains have challenged worldwide policy interventions. Anticipating the emergence of these mutations to plan ahead adequate policies, and understanding how human behaviors may affect the evolution of viruses by coevolution, are key challenges. In this article, we propose coevolution with genetic algorithms (GAs) as a credible approach to model this relationship, highlighting its implications, potenti…
From late December, 2019, the novel Corona-Virus began to spread in the mainland of China. For predicting the trend of the Corona Virus spread, several time delay dynamic systems (TDD) are proposed. In this paper, we establish a novel fractional time delay dynamic system (FTDD) to describe the local outbreak of COVID-19. The fractional derivative is introduced to account for the sub-diffusion process of the confirmed and cured peoples growth. Based on the public health data by the government, we propose a stable reconstruction algorithm of the coefficients. The reconstructed coefficients are u…
We present a compartmental mathematical model with demography for the spread of the COVID-19 disease, considering also asymptomatic infectious individuals. We compute the basic reproductive ratio of the model and study the local and global stability for it. We solve the model numerically based on the case of Italy. We propose a vaccination model and we derive threshold conditions for preventing infection spread in the case of imperfect vaccines.
We consider the $SEIRS$ epidemiology model with such features of the COVID-19 outbreak as: abundance of unidentified infected individuals, limited time of immunity and a possibility of vaccination. Within a compartmental realization of this model, we found the disease-free and the endemic stationary states. They exist in their respective restricted regions of the le via linear stability analysis. The expression for the basic reproductive number is obtained as well. The positions and heights of a first peak for the fractions of infected individuals are obtained numerically and are fitted to sim…
In individual SARS-CoV-2 outbreaks, the count of confirmed cases and deaths follow a Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on universal properties of the network of social interactions. We test this hypothesis by simulating the propagation of a virus on networks of different topologies. Our main finding is that Gompertz growth observed for early outbreaks occurs only for a scale-free network, in which nodes with many more neighbors than average are common. These nodes that have ve…
While understanding of periodic recurrent waves of Covid-19 epidemics would aid to combat the pandemics, quantitative analysis of data over a two years period from the outbreak, is lacking. The complexity of Covid-19 recurrent waves is related with the concurrent role of i) the containment measures enforced to mitigate the epidemics spreading ii) the rate of viral gene mutations, and iii) the variable immune response of the host implemented by vaccination. This work focuses on the effect of massive vaccination and gene variants on the recurrent waves in a representative case of countries enfor…
Returning universities to full on-campus operations while the COVID-19 pandemic is ongoing has been a controversial discussion in many countries. The risk of large outbreaks in dense course settings is contrasted by the benefits of in-person teaching. Transmission risk depends on a range of parameters, such as vaccination coverage and efficacy, number of contacts and adoption of non-pharmaceutical intervention measures (NPIs). Due to the generalised academic freedom in Europe, many universities are asked to autonomously decide on and implement intervention measures and regulate on-campus opera…
There were 27 novel coronavirus pneumonia cases found in Wuhan, China in December 2019, named as 2019-nCoV temporarily and COVID-19 formally by WHO on 11 February, 2020. In December 2019 and January 2020, COVID-19 has spread in large scale among the population, which brought terrible disaster to the life and property of the Chinese people. In this paper, we will first analyze the feature and pattern of the virus transmission, and discuss the key impact factors and uncontrollable factors of epidemic transmission based on public data. Then the virus transmission can be modelled and used for the …
We analyze the paper of Nathan D. Grubaugh et al. (Nature 546, 401-405, 2017) and find that it does not offer a convincing quantitative explanation for what generated the temporal distribution of human Zika virus (ZIKV) cases shown in their paper (Fig. 1d). We criticize this aspect because it is this understanding of how human cases develop from day-today and week-to-week within an area such as these Ground Zeros, that policymakers need in order to mitigate future outbreaks. We present results that strongly suggest that the missing piece is everyday human visit-revisit behavior. These results …
The Covid-19 outbreak of 2020 has required many governments to develop mathematical-statistical models of the outbreak for policy and planning purposes. This work provides a tutorial on building a compartmental model using Susceptibles, Exposed, Infected, Recovered and Deaths status through time. A Bayesian Framework is utilized to perform both parameter estimation and predictions. This model uses interventions to quantify the impact of various government attempts to slow the spread of the virus. Predictions are also made to determine when the peak Active Infections will occur.
Motivated by massive outbreaks of COVID-19 that occurred even in populations with high vaccine uptake, we propose a novel multi-population temporal network model for the spread of recurrent epidemic diseases. We study the effect of human behavior, testing, and vaccination campaigns on the control of local outbreaks and infection prevalence. Our modeling framework decouples the vaccine effectiveness in protecting against transmission and the development of severe symptoms. Furthermore, the framework accounts for the polarizing effect of the decision to vaccinate and captures homophily, i.e., th…
The dynamics of epidemics depend on how people's behavior changes during an outbreak. At the beginning of the epidemic, people do not know about the virus, then, after the outbreak of epidemics and alarm, they begin to comply with the restrictions and the spreading of epidemics may decline. Over time, some people get tired/frustrated by the restrictions and stop following them (exhaustion), especially if the number of new cases drops down. After resting for a while, they can follow the restrictions again. But during this pause the second wave can come and become even stronger then the first on…
We interpret attitudes towards science and pseudosciences as cultural traits that diffuse in society through communication efforts exerted by agents. We present a tractable model that allows us to study the interaction among the diffusion of an epidemic, vaccination choices, and the dynamics of cultural traits. We apply it to study the impact of homophily between pro-vaxxers and anti-vaxxers on the total number of cases (the cumulative infection). We show that, during the outbreak of a disease, homophily has the direct effect of decreasing the speed of recovery. Hence, it may increase the numb…
Urban mobility needs alternative sustainable travel modes to keep our pandemic cities in motion. Ride-pooling, where a single vehicle is shared by more than one traveller, is not only appealing for mobility platforms and their travellers, but also for promoting the sustainability of urban mobility systems. Yet, the potential of ride-pooling rides to serve as a safe and effective alternative given the personal and public health risks considerations associated with the COVID-19 pandemic is hitherto unknown. To answer this, we combine epidemiological and behavioural shareability models to examine…
In a world being hit by waves of COVID-19, vaccination is a light on the horizon. However, the roll-out of vaccination strategies and their influence on the pandemic are still open problems. In order to compare the effect of various strategies proposed by the World Health Organization and other authorities, a previously developed SEIRS stochastic model of geographical spreading of the virus is extended by adding a compartment for vaccinated people. The parameters of the model were fitted to describe the pandemic evolution in Argentina, Mexico and Spain to analyze the effect of the proposed vac…
Although previous infection and vaccination provide protection against SARS-CoV-2 infection, both reinfection and breakthrough infection are possible events whose occurrence would increase with time after first exposure to the antigen and with the emergence of new variants of the virus. Periodic vaccination could counteract this decline in protection. In the present work, our aim was to develop and explore a model of SARS-CoV-2 spread with vaccination, reinfection and breakthrough infection. A modified deterministic SIS (Susceptible-Infected-Susceptible) model represented by a system of differ…
We model the mobility of mobile phone users to study the fundamental spreading patterns characterizing a mobile virus outbreak. We find that while Bluetooth viruses can reach all susceptible handsets with time, they spread slowly due to human mobility, offering ample opportunities to deploy antiviral software. In contrast, viruses utilizing multimedia messaging services could infect all users in hours, but currently a phase transition on the underlying call graph limits them to only a small fraction of the susceptible users. These results explain the lack of a major mobile virus breakout so fa…
Due to its high lethality amongst the elderly, the safety of nursing homes has been of central importance during the COVID-19 pandemic. With test procedures becoming available at scale, such as antigen or RT-LAMP tests, and increasing availability of vaccinations, nursing homes might be able to safely relax prohibitory measures while controlling the spread of infections (meaning an average of one or less secondary infections per index case). Here, we develop a detailed agent-based epidemiological model for the spread of SARS-CoV-2 in nursing homes to identify optimal prevention strategies. The…
As of July, 2020, acute respiratory syndrome caused by coronavirus COVID-19 is spreading over the world and causing severe economic damages. While minimizing human contact is effective in managing the outbreak, it causes severe economic losses. Strategies solving this dilemma by considering interrelation between the spread of the virus and economic activities are in urgent needs for mitigating the health and economic damage. Here we propose an abstract agent-based model for the outbreak of COVID-19 in which economic activities are taken into account. The computational simulation of the model r…
We propose a multi-layer network model for the spread of COVID-19 that accounts for interactions within the family, between schoolmates, and casual contacts in the population. We utilize the proposed model-calibrated on epidemiological and demographic data-to investigate current questions concerning the implementation of non-pharmaceutical interventions (NPIs) during the vaccination campaign. Specifically, we consider scenarios in which the most fragile population has already received the vaccine, and we focus our analysis on the role of schools as drivers of the contagions and on the implemen…
