arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2102.00102math.STcs.LGstat.MEstat.MLstat.TH
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单时间序列的自适应序贯设计

Adaptive Sequential Design for a Single Time-Series

University of California, Berkeley(加州大学伯克利分校)

Ivana Malenica, Aurelien Bibaut, Mark J. van der Laan

摘要:

目前的工作是出于对精确医学的强大统计方法的需求;因此,我们解决了在任何时间点为单个单元提供可操作推断的统计方法的需求。我们的目标是学习设计的受控组件的最佳,未知的选择,以优化预期的结果;有了这个,我们根据随着时间的推移收集的个人数据,为未来的时间点实验调整随机化机制。我们的研究结果表明,人们可以学习的最佳规则的基础上,一个单一的样本,从而调整设计在任何点t的有效推断的平均目标参数。这项工作为统计精确医学领域做出了一些贡献。首先,我们定义了一个一般类的平均值的条件因果参数定义的当前上下文的单个单元时间序列数据。我们定义了一个非参数模型的概率分布的时间序列在几个假设下,并旨在充分利用顺序随机化的估计过程中,通过双鲁棒结构的有效影响曲线的建议的目标参数。我们提出了多个勘探开发策略分配治疗,估计最佳规则的方法。最后,我们提出了最佳治疗规则下的平均值的数据自适应推理的研究,其中目标参数随着时间的推移而适应,以响应所观察到的个人背景。我们的目标参数是路径可微的,具有双重鲁棒性的有效影响函数-这使得它比以前提出的变化更容易估计。我们的极限分布的特征,我们的估计下的Donsker条件下表示的括号熵的概念,适应鞅设置。

英文摘要:

The current work is motivated by the need for robust statistical methods for precision medicine; as such, we address the need for statistical methods that provide actionable inference for a single unit at any point in time. We aim to learn an optimal, unknown choice of the controlled components of the design in order to optimize the expected outcome; with that, we adapt the randomization mechanism for future time-point experiments based on the data collected on the individual over time. Our results demonstrate that one can learn the optimal rule based on a single sample, and thereby adjust the design at any point t with valid inference for the mean target parameter. This work provides several contributions to the field of statistical precision medicine. First, we define a general class of averages of conditional causal parameters defined by the current context for the single unit time-series data. We define a nonparametric model for the probability distribution of the time-series under few assumptions, and aim to fully utilize the sequential randomization in the estimation procedure via the double robust structure of the efficient influence curve of the proposed target parameter. We present multiple exploration-exploitation strategies for assigning treatment, and methods for estimating the optimal rule. Lastly, we present the study of the data-adaptive inference on the mean under the optimal treatment rule, where the target parameter adapts over time in response to the observed context of the individual. Our target parameter is pathwise differentiable with an efficient influence function that is doubly robust - which makes it easier to estimate than previously proposed variations. We characterize the limit distribution of our estimator under a Donsker condition expressed in terms of a notion of bracketing entropy adapted to martingale settings.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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