Hypertension is a potentially unsafe health ailment, which can be indicated directly from the Blood pressure (BP). Hypertension always leads to other health complications. Continuous monitoring of BP is very important; however, cuff-based BP measurements are discrete and uncomfortable to the user. To address this need, a cuff-less, continuous and a non-invasive BP measurement system is proposed using Photoplethysmogram (PPG) signal and demographic features using machine learning (ML) algorithms. PPG signals were acquired from 219 subjects, which undergo pre-processing and feature extraction steps. Time, frequency and time-frequency domain features were extracted from the PPG and their derivative signals. Feature selection techniques were used to reduce the computational complexity and to decrease the chance of over-fitting the ML algorithms. The features were then used to train and evaluate ML algorithms. The best regression models were selected for Systolic BP (SBP) and Diastolic BP (DBP) estimation individually. Gaussian Process Regression (GPR) along with ReliefF feature selection algorithm outperforms other algorithms in estimating SBP and DBP with a root-mean-square error (RMSE) of 6.74 and 3.59 respectively. This ML model can be implemented in hardware systems to continuously monitor BP and avoid any critical health conditions due to sudden changes.
Purdue University（普渡大学）；Qatar University（卡塔尔大学）；University of British Columbia（不列颠哥伦比亚大学）；BUET（孟加拉国工程技术大学）
Cardiovascular diseases are one of the most severe causes of mortality, taking a heavy toll of lives annually throughout the world. The continuous monitoring of blood pressure seems to be the most viable option, but this demands an invasive process, bringing about several layers of complexities. This motivates us to develop a method to predict the continuous arterial blood pressure (ABP) waveform through a non-invasive approach using photoplethysmogram (PPG) signals. In addition we explore the advantage of deep learning as it would free us from sticking to ideally shaped PPG signals only, by m…
SSN College of Engineering（SSN工程学院）；College of Engineering, Guindy（Guindy工程学院）；Solarillion Foundation（Solarillion基金会）
Blood pressure (BP) is one of the most influential bio-markers for cardiovascular diseases and stroke; therefore, it needs to be regularly monitored to diagnose and prevent any advent of medical complications. Current cuffless approaches to continuous BP monitoring, though non-invasive and unobtrusive, involve explicit feature engineering surrounding fingertip Photoplethysmogram (PPG) signals. To circumvent this, we present an end-to-end deep learning solution, BP-Net, that uses PPG waveform to estimate Systolic BP (SBP), Mean Average Pressure (MAP), and Diastolic BP (DBP) through intermediate…
Qatar University（卡塔尔大学）；Universiti Kebangsaan Malaysia（马来西亚国立大学）；BUET（孟加拉国工程技术大学）
Cardiovascular diseases are the most common causes of death around the world. To detect and treat heart-related diseases, continuous Blood Pressure (BP) monitoring along with many other parameters are required. Several invasive and non-invasive methods have been developed for this purpose. Most existing methods used in the hospitals for continuous monitoring of BP are invasive. On the contrary, cuff-based BP monitoring methods, which can predict Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP), cannot be used for continuous monitoring. Several studies attempted to predict BP fr…
The paper proposes accurate Blood Pressure Monitoring (BPM) based on a single-site Photoplethysmographic (PPG) sensor and provides an energy-efficient solution on edge cuffless wearable devices. Continuous PPG signal preprocessed and used as input of the Artificial Neural Network (ANN), and outputs systolic BP (SBP), diastolic BP (DBP), and mean arterial BP (MAP) values for each heartbeat. The improvement of the BPM accuracy is obtained by removing outliers in the preprocessing step and the whole-based inputs compared to parameter-based inputs extracted from the PPG signal. Performance obtaine…
Goal: Although photoplethysmogram (PPG) and electrocardiogram (ECG) signals can be used to estimate blood pressure (BP) by extracting various features, the changes in morphological contours of both PPG and ECG signals due to various diseases of circulatory system and interaction of other physiological systems make the extraction of such features very difficult. Methods: In this work, we propose a waveform-based hierarchical Artificial Neural Network - Long Short Term Memory (ANN-LSTM) model for BP estimation. The model consists of two hierarchy levels, where the lower hierarchy level uses ANNs…
Ingenuity Labs Research Institute（Ingenuity Labs 研究院）
Electrocardiogram (ECG) is the electrical measurement of cardiac activity, whereas Photoplethysmogram (PPG) is the optical measurement of volumetric changes in blood circulation. While both signals are used for heart rate monitoring, from a medical perspective, ECG is more useful as it carries additional cardiac information. Despite many attempts toward incorporating ECG sensing in smartwatches or similar wearable devices for continuous and reliable cardiac monitoring, PPG sensors are the main feasible sensing solution available. In order to tackle this problem, we propose CardioGAN, an advers…
Photoplethysmogram (PPG) signal-based blood pressure (BP) estimation is a promising candidate for modern BP measurements, as PPG signals can be easily obtained from wearable devices in a non-invasive manner, allowing quick BP measurement. However, the performance of existing machine learning-based BP measuring methods still fall behind some BP measurement guidelines and most of them provide only point estimates of systolic blood pressure (SBP) and diastolic blood pressure (DBP). In this paper, we present a cutting-edge method which is capable of continuously monitoring BP from the PPG signal a…
Deriving Health Metrics from the Photoplethysmogram: Benchmarks and Insights from MIMIC-III-Ext-PPG
AI4Health Department, Oldenburg University（AI4Health部门，旧恩斯特堡大学）；Department of Data Science and AI, National Physical Laboratory（数据科学与人工智能系，国家物理实验室）；School of Mathematics and Physics, University of Surrey（数学与物理学院，萨里大学）；Department of Public Health and Primary Care, University of Cambridge（公共卫生与初级保健系，剑桥大学）
Infant Research Centre（婴儿研究中心）；School of Computing（计算机学院）；Dublin City University（都柏林城市大学）；Department of Electrical Engineering（电气工程系）；KU Leuven（鲁汶大学）；Cork University Maternity Hospital（科克大学妇产医院）；Insight SFI Research Centre（Insight SFI研究中心）
Ischemic heart disease is the highest cause of mortality globally each year. This not only puts a massive strain on the lives of those affected but also on the public healthcare systems. To understand the dynamics of the healthy and unhealthy heart doctors commonly use electrocardiogram (ECG) and blood pressure (BP) readings. These methods are often quite invasive, in particular when continuous arterial blood pressure (ABP) readings are taken and not to mention very costly. Using machine learning methods we seek to develop a framework that is capable of inferring ABP from a single optical phot…
This paper presents a novel approach based on pulse transit time (PTT) for the estimation of blood pressure (BP). In order to achieve this goal, a data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG) and photoplethysmogram (PPG). These two signals can derive PTT values. Meanwhile, a force-sensing resistor (FSR) is placed under the cuff of the BP reference device to mark the moments of measurements accurately via recording instantaneous cuff pressure. For deriving the PTT-BP models, a calibration procedure including a supervised physical exercise is conduc…
This study explores extended feature space that is indicative of blood pressure (BP) changes for better estimation of continuous BP in an unobtrusive way. A total of 222 features were extracted from noninvasively acquired electrocardiogram (ECG) and photoplethysmogram (PPG) signals with the subject undergoing coronary angiography and/or percutaneous coronary intervention, during which intra-arterial BP was recorded simultaneously with the subject at rest and while administering drugs to induce BP variations. The association between the extracted features and the BP components, i.e. systolic BP…
GRN-Transformer: Enhancing Motion Artifact Detection in PICU Photoplethysmogram Signals
École de Technologie Supérieure, University of Québec（魁北克大学高等技术学院）；University of Luxembourg（卢森堡大学）；CHU Sainte-Justine Research Center, CHU Sainte-Justine Hospital, University of Montreal（蒙特利尔大学圣朱斯蒂安医院研究中心）
Benchmarking and Enhancing PPG-Based Cuffless Blood Pressure Estimation Methods
Department of Engineering Technology, University of Houston, Texas, USA（工程科技系，休斯顿大学，德克萨斯州，美国）；Department of Electrical and Computer Engineering, University of Houston, Texas, USA（电气与计算机工程系，休斯顿大学，德克萨斯州，美国）；Department of Information Science Technology, University of Houston, Texas, USA（信息科学科技系，休斯顿大学，德克萨斯州，美国）；Department of Cardiovascular Surgery, Houston Methodist Hospital, Texas, USA（心血管外科系，休斯顿方法医院，德克萨斯州，美国）；Department of Biomedical Engineering, University of Houston, Texas, USA（生物医学工程系，休斯顿大学，德克萨斯州，美国）
This paper presents a novel blood pressure (BP) estimation method based on pulse transit time (PTT) and pulse arrival time (PAT) to estimate the systolic BP (SBP) and the diastolic BP (DBP). A data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG), photoplethysmogram, and electrocardiogram (ECG). PCG and ECG perform as the proximal timing reference to obtain PTT and PAT indices, respectively. In order to derive a BP estimator model, a calibration procedure, including a supervised physical exercise, is conducted for each individual, which causes changes in t…
The presented study aims to estimate blood pressure (BP) using photoplethysmogram (PPG) signals while employing multiple machine learning models. The study proposes a novel algorithm for signal reconstruction, which utilizes the semi-classical signal analysis (SCSA) technique. The proposed algorithm optimises the semi-classical constant and eliminates the trade-off between complexity and accuracy in reconstruction. The reconstructed signals' spectral features are extracted and incorporated with clinically relevant PPG and its second derivative's (SDPPG) morphological features. The developed me…
Large Language Models for Cuffless Blood Pressure Measurement From Wearable Biosignals
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；Hong Kong Polytechnic University（香港理工大学）；Shenzhen Polytechnic University（深圳职业技术大学）
This paper explores a novel method for anxiety detection in older adults using simple wristband sensors such as Electrodermal Activity (EDA) and Photoplethysmogram (PPG) and a context-based feature. The proposed method for anxiety detection combines features from a single physiological signal with an experimental context-based feature to improve the performance of the anxiety detection model. The experimental data for this work is obtained from a year-long experiment on 41 healthy older adults (26 females and 15 males) in the age range 60-80 with mean age 73.36+-5.25 during a Trier Social Stre…
The 0-1 test distinguishes between regular and chaotic dynamics for a deterministic system using a time series. Here is presented how to use the test with biological signals. Between all the biological signals obtained as a times series, we present the results of applying the test and study with more details the photoplethysmogram (PPG) from different subjects; different biological signals of one subject are analyzed also with the test. PPG signal contains extensive physiological dynamics information; mainly used to heart rate monitoring and blood oxygen saturation. Based on its understandable…
With the ongoing heart problems of the population worldwide, the medical requirements of the people are expected to increase. Electrocardiogram (ECG) is one of the proven to capture the heart response signal to assess the electrical and muscular functions of the heart. The ECG setup is expensive and needs proper training, and of course, it is not instant. For fast, accurate heart parameter monitoring, scientists pay attention to the photoplethysmogram signal (PPG), based on the light intensity of a particular wavelength. Android smartphone with a good quality camera has come to ordinary people…
