We extend previous weak well-posedness results obtained in Frigeri et al. (2017) concerning a non-local variant of a diffuse interface tumor model proposed by Hawkins-Daarud et al. (2012). The model consists of a non-local Cahn--Hilliard equation with degenerate mobility and singular potential for the phase field variable, coupled to a reaction-diffusion equation for the concentration of a nutrient. We prove the existence of strong solutions to the model and establish some high order continuous dependence estimates, even in the presence of concentration-dependent mobilities for the nutrient variable in two spatial dimensions. Then, we apply the new regularity results to study an inverse problem identifying the initial tumor distribution from measurements at the terminal time. Formulating the Tikhonov regularised inverse problem as a constrained minimisation problem, we establish the existence of minimisers and derive first-order necessary optimality conditions.
We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a reaction-diffusion equation. For non-degenerate mobilities and smooth potentials, we derive well-posedness results, which are the non-local analogue of those obtained in Frigeri et al. (European J. Appl. Math. 2015). Furthermore, we establish existence of weak solutions for the case of degenerate mobilities and singular potentials, which serves to confine the …
This paper tackles the approximation of surface diffusion flow using a Cahn--Hilliard-type model. We introduce and analyze a new second order variational phase field model which associates the classical Cahn--Hilliard energy with two degenerate mobilities. This association allows to gain an order of approximation of the sharp limit. In a second part, we propose some simple and efficient numerical schemes to approximate the solutions, and we provide numerical 2D and 3D experiments that illustrate the interest of our model in comparison with other Cahn--Hilliard models.
Cahn-Hilliard models are central for describing the evolution of interfaces in phase separation processes and free boundary problems. In general, they have non-constant and often degenerate mobilities. However, in the latter case, the spontaneous appearance of points of vanishing mobility and their impact on the solution are not well understood. In this paper we develop a singular perturbation theory to identify a range of degeneracies for which the solution of the Cahn-Hilliard equation forms a singularity in infinite time. This analysis forms the basis for a rigorous sharp interface theory a…
In this paper, we study the sharp interface limit for solutions of the Cahn-Hilliard equation with disparate mobilities. This means that the mobility function degenerates in one of the two energetically favorable configurations, suppressing the diffusion in that phase. First, we construct suitable weak solutions to this Cahn-Hilliard equation. Second, we prove precompactness of these solutions under natural assumptions on the initial data. Third, under an additional energy convergence assumption, we show that the sharp interface limit is a distributional solution to the Hele-Shaw flow with opt…
We prove an existence and uniqueness result for solutions to nonlinear diffusion equations with degenerate mobility posed on a bounded interval for a certain density $u$. In case of \emph{fast-decay} mobilities, namely mobilities functions under a Osgood integrability condition, a suitable coordinate transformation is introduced and a new nonlinear diffusion equation with linear mobility is obtained. We observe that the coordinate transformation induces a mass-preserving scaling on the density and the nonlinearity, described by the original nonlinear mobility, is included in the diffusive proc…
We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features two interacting cell populations with their mutual transitions and involves tissue-dependent degenerate diffusion and haptotaxis for the moving subpopulation. The proliferating cells and the tissue evolution are characterized by way of ODEs for the respective densities. We prove the global existence of weak solutions and illustrate the model behaviour by numerical …
We consider a diffuse interface model for incompressible isothermal mixtures of two immiscible fluids with matched constant densities. This model consists of the Navier-Stokes system coupled with a convective nonlocal Cahn-Hilliard equation with non-constant mobility. We first prove the existence of a global weak solution in the case of non-degenerate mobilities and regular potentials of polynomial growth. Then we extend the result to degenerate mobilities and singular (e.g. logarithmic) potentials. In the latter case we also establish the existence of the global attractor in dimension two. Us…
There has been recently an important interest in deriving rigorously the Cahn-Hilliard equation from the nonlocal equation, also called aggregation equation. So far, only non-degenerate mobilities were treated. Since we are motivated by models for the biomechanics of living tissues, it is useful to include degenerate motilities. In this framework, we present a new method to show the convergence of the nonlocal to the local degenerate Cahn-Hilliard equation. The method includes the use of nonlocal Poincaré and compactness inequalities.
Motivated by tumor growth in Cancer Biology, we provide a complete analysis of existence and non-existence of invasive fronts for the reduced Gatenby--Gawlinski model \[ \partial_t U = U\{f(U)-dV\}, \qquad \partial_t V = \partial_x \{f(U)\,\partial_x V\} + r V f(V), \] where $f(u) = 1-u$ and the parameters $d,r$ are positive. Denoting by $(\mathcal{U},\mathcal{V})$ the traveling wave profile and by $(\mathcal{U}_\pm,\mathcal{V}_\pm)$ its asymptotic states at $\pm\infty$, we investigate existence in the regimes i) $d > 1$ (homogeneous invasion) : $(\mathcal{U}_-,\mathcal{V}_-) = (0,1)$, $(\math…
Global Weak Solutions of a Thermodynamically Consistent Diffuse Interface Model for Nonhomogeneous Incompressible Two-phase Flows with a Soluble Surfactant
The aim of this work is to prove the global-in-time existence of weak solutions for a viscoelastic phase separation model in three space dimensions. To this end we apply the relative energy concept provided by [3]. We consider the case of regular polynomial-type potentials and positive mobilities, as well as the degenerate case with logarithmic potential and vanishing mobility.
The aim of this paper is to prove global in time existence of weak solutions for a viscoelastic phase separation. We consider the case with singular potentials and degenerate mobilities. Our model couples the diffusive interface model with the Peterlin-Navier-Stokes equations for viscoelastic fluids. To obtain the global in time existence of weak solutions we consider appropriate approximations by solutions of the viscoelastic phase separation with a regular potential and build on the corresponding energy and entropy estimates.
This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly degenerate parabolic equations, which include phenomenological terms related to specific cell functions. The paper discusses general modeling guidelines for such terms, as well as for initial and boundary conditions, aiming at both biological consistency and mathematical robustness of the resulting problems. Particularly, it addresses some qualitative properties such…
We study a non-local version of the Cahn-Hilliard dynamics for phase separation in a two-component incompressible and immiscible mixture with linear mobilities. In difference to the celebrated local model with nonlinear mobility, it is only assumed that the divergences of the two fluxes --- but not necessarily the fluxes themselves --- annihilate each other. Our main result is a rigorous proof of existence of weak solutions. The starting point is the formal representation of the dynamics as a constrained gradient flow in the Wasserstein metric. We then show that time-discrete approximations by…
We study the sharp interface limit and well-posedness of a phase field model for self-climb of prismatic dislocation loops in periodic settings. The model is set up in a Cahn-Hilliard/Allen-Cahn framework featured with degenerate phase-dependent diffusion mobility with an additional stablizing function. Moreover, a nonlocal climb force is added to the chemical potential. We introduce a notion of weak solutions for the nonlinear model. The existence result is obtained by approximations of the proposed model with nondegenerate mobilities. Lastly, the numerical simulations are performed to valida…
We prove the existence of nonnegative martingale solutions to a class of stochastic degenerate-parabolic fourth-order PDEs arising in surface-tension driven thin-film flow influenced by thermal noise. The construction applies to a range of mobilites including the cubic one which occurs under the assumption of a no-slip condition at the liquid-solid interface. Since their introduction more than 15 years ago, by Davidovitch, Moro, and Stone and by Grün, Mecke, and Rauscher, the existence of solutions to stochastic thin-film equations for cubic mobilities has been an open problem, even in the cas…
We consider density solutions for gradient flow equations of the form $u_t = \nabla \cdot ( γ(u) \nabla \mathrm N(u))$, where $\mathrm N$ is the Newtonian repulsive potential in the whole space $\mathbb R^d$ with the nonlinear convex mobility $γ(u)=u^α$, and $α>1$. We show that solutions corresponding to compactly supported initial data remain compactly supported for all times leading to moving free boundaries as in the linear mobility case $γ(u)=u$. For linear mobility it was shown that there is a special solution in the form of a disk vortex of constant intensity in space $u=c_1t^{-1}$ suppo…
