Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In this work, we propose a novel deep neural network using both CMR images and patient metadata to directly predict cardiac shape parameters. The proposed method uses the promising ability of statistical shape models to simplify shape complexity and variability together with the advantages of convolutional neural networks for the extraction of solid visual features. To the best of our knowledge, this is the first work that uses such an approach for 3D cardiac shape prediction. We validated our proposed CMR analytics method against a reference cohort containing 500 3D shapes of the cardiac ventricles. Our results show broadly significant agreement with the reference shapes in terms of the estimated volume of the cardiac ventricles, myocardial mass, 3D Dice, and mean and Hausdorff distance.
University of California, Los Angeles（加州大学洛杉矶分校）；Nuffield College, Oxford University（牛津大学纳菲尔德学院）；Oxford Man Institute, Oxford University（牛津大学牛津曼研究所）；Alan Turing Institute（艾伦·图灵研究所）
Given the limited pool of donor organs, accurate predictions of survival on the wait list and post transplantation are crucial for cardiac transplantation decisions and policy. However, current clinical risk scores do not yield accurate predictions. We develop a new methodology (ToPs, Trees of Predictors) built on the principle that specific predictors should be used for specific clusters within the target population. ToPs discovers these specific clusters of patients and the specific predictor that perform best for each cluster. In comparison with current clinical risk scoring systems, our me…
Compositional Segmentation of Cardiac Images Leveraging Metadata
School of Electronic Engineering and Computer Science, Queen Mary University of London（伦敦玛丽女王大学电子工程与计算机科学学院）；Queen Mary’s Digital Environment Research Institute (DERI)（玛丽女王数字环境研究所）；Department of Computer Science, University College London（伦敦大学学院计算机科学系）；School of Engineering and Materials Science, Queen Mary University of London（伦敦玛丽女王大学工程与材料科学学院）
Learning from Acquisition: Metadata-driven Multimodal Pre-training for Cardiac MRI
Department of Surgery & Cancer（外科与癌症系）；Bioengineering Department and Imperial-X（生物工程系和Imperial-X）；National Heart and Lung Institute（国家心脏和肺研究所）；Cardiovascular Research Centre（心血管研究中心）；School of Biomedical Engineering & Imaging Sciences（生物医学工程与成像科学学院）
Stanford University（斯坦福大学）；School of Medicine, Stanford University（斯坦福大学医学院）
Self-supervised contrastive learning between pairs of multiple views of the same image has been shown to successfully leverage unlabeled data to produce meaningful visual representations for both natural and medical images. However, there has been limited work on determining how to select pairs for medical images, where availability of patient metadata can be leveraged to improve representations. In this work, we develop a method to select positive pairs coming from views of possibly different images through the use of patient metadata. We compare strategies for selecting positive pairs for ch…
In this work, we compare the performance of six state-of-the-art deep neural networks in classification tasks when using only image features, to when these are combined with patient metadata. We utilise transfer learning from networks pretrained on ImageNet to extract image features from the ISIC HAM10000 dataset prior to classification. Using several classification performance metrics, we evaluate the effects of including metadata with the image features. Furthermore, we repeat our experiments with data augmentation. Our results show an overall enhancement in performance of each network as as…
University of Kansas（堪萨斯大学）；Rochester Institute of Technology（罗切斯特理工学院）
Patient-specific left ventricle (LV) myocardial models have the potential to be used in a variety of clinical scenarios for improved diagnosis and treatment plans. Cine cardiac magnetic resonance (MR) imaging provides high resolution images to reconstruct patient-specific geometric models of the LV myocardium. With the advent of deep learning, accurate segmentation of cardiac chambers from cine cardiac MR images and unsupervised learning for image registration for cardiac motion estimation on a large number of image datasets is attainable. Here, we propose a deep leaning-based framework for th…
CHMMOTv1 -- Cardiac and Hepatic Multi-Echo (T2*) MRI Images and Clinical Dataset for Iron Overload on Thalassemia Patients
Isfahan University of Medical Sciences（伊斯法罕医科大学）；Islamic Azad University Science and Research Branch（伊斯兰阿扎德大学科学研究分支）；Tehran University of Medical Sciences（德黑兰医科大学）
SDF4CHD: Generative Modeling of Cardiac Anatomies with Congenital Heart Defects
Stanford University（斯坦福大学）；Cardiovascular Institute（心血管研究所）；ETH Zurich and University Zurich（苏黎世联邦理工学院和苏黎世大学）；Institute for Biomedical Engineering（生物医学工程研究所）
Towards Cardiac MRI Foundation Models: Comprehensive Visual-Tabular Representations for Whole-Heart Assessment and Beyond
School of Computation, Information and Technology, Technical University of Munich（慕尼黑工业大学计算、信息与技术学院）；School of Medicine, Klinikum Rechts der Isar, Technical University of Munich（慕尼黑工业大学伊萨尔河畔右岸医院医学院）；Data Science Institute, Imperial College London（帝国理工学院数据科学研究所）；Department of Computing, Imperial College London（帝国理工学院计算系）；Department of Computer Science, University of Sheffield（谢菲尔德大学计算机科学系）；Department of Quantitative Biomedicine, University of Zurich（苏黎世大学定量生物医学系）
Pontificia Universidad Católica de Chile（智利天主教大学）；University of Graz（格拉茨大学）；Medical University of Graz（格拉茨医科大学）；University of Pennsylvania（宾夕法尼亚大学）；Università della Svizzera italiana（瑞士意大利语区大学）
We propose FiberNet, a method to estimate \emph{in-vivo} the cardiac fiber architecture of the human atria from multiple catheter recordings of the electrical activation. Cardiac fibers play a central role in the electro-mechanical function of the heart, yet they are difficult to determine in-vivo, and hence rarely truly patient-specific in existing cardiac models. FiberNet learns the fiber arrangement by solving an inverse problem with physics-informed neural networks. The inverse problem amounts to identifying the conduction velocity tensor of a cardiac propagation model from a set of sparse…
Image Sciences Institute, University Medical Center Utrecht（乌得勒支大学医学中心影像科学研究所）；University Medical Center Utrecht（乌得勒支大学医学中心）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）；Utrecht University（乌得勒支大学）
In patients with obstructive coronary artery disease, the functional significance of a coronary artery stenosis needs to be determined to guide treatment. This is typically established through fractional flow reserve (FFR) measurement, performed during invasive coronary angiography (ICA). We present a method for automatic and non-invasive detection of patients requiring ICA, employing deep unsupervised analysis of complete coronary arteries in cardiac CT angiography (CCTA) images. We retrospectively collected CCTA scans of 187 patients, 137 of them underwent invasive FFR measurement in 192 dif…
United Imaging Intelligence（联影智能）；UIH America, Inc.（联影美国公司）
Real-time cardiac cine MRI does not require ECG gating in the data acquisition and is more useful for patients who can not hold their breaths or have abnormal heart rhythms. However, to achieve fast image acquisition, real-time cine commonly acquires highly undersampled data, which imposes a significant challenge for MRI image reconstruction. We propose a residual convolutional RNN for real-time cardiac cine reconstruction. To the best of our knowledge, this is the first work applying deep learning approach to Cartesian real-time cardiac cine reconstruction. Based on the evaluation from radiol…
Global and Local Contrastive Learning for Joint Representations from Cardiac MRI and ECG
Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany（人工智能在医疗与医学中的研究中心，技术大学慕尼黑（TUM）及慕尼黑技术大学医院）；School of Medicine, Klinikum rechts der Isar, TUM, Germany（医学院，右岸克里克医院，TUM，德国）；Department of Computing, Imperial College London, UK（计算学院，伦敦帝国学院，英国）；Munich Center for Machine Learning (MCML), Munich, Germany（慕尼黑机器学习中心（MCML），慕尼黑，德国）
Image Sciences Institute, University Medical Center Utrecht（乌得勒支大学医学中心影像科学研究所）；University Medical Center Utrecht（乌得勒支大学医学中心）；Utrecht University（乌得勒支大学）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）
Treatment of patients with obstructive coronary artery disease is guided by the functional significance of a coronary artery stenosis. Fractional flow reserve (FFR), measured during invasive coronary angiography (ICA), is considered the gold standard to define the functional significance of a coronary stenosis. Here, we present a method for non-invasive detection of patients with functionally significant coronary artery stenosis, combining analysis of the coronary artery tree and the left ventricular (LV) myocardium in cardiac CT angiography (CCTA) images. We retrospectively collected CCTA sca…
Cardiac Digital Twins at Scale from MRI: Open Tools and Representative Models from ~55000 UK Biobank Participants
School of Biomedical Engineering & Imaging Sciences, King’s College London（伦敦国王学院生物医学工程与成像科学学院）；The Cardiac Electro-Mechanics Research Group, Imperial College London（伦敦帝国理工学院心脏电机械学研究组）；The Alan Turing Institute, London（伦敦艾伦·图灵研究所）；Department of Cardiology, University Medical Center Utrecht（乌得勒支大学医学中心心内科部）；ETH Zurich（苏黎世联邦理工学院）
In the clinical environment, myocardial infarction (MI) as one com-mon cardiovascular disease is mainly evaluated based on the late gadolinium enhancement (LGE) cardiac magnetic resonance images (CMRIs). The auto-matic segmentations of left ventricle (LV), right ventricle (RV), and left ven-tricular myocardium (LVM) in the LGE CMRIs are desired for the aided diag-nosis in clinic. To accomplish this segmentation task, this paper proposes a modified U-net architecture by combining multi-sequence CMRIs, including the cine, LGE, and T2-weighted CMRIs. The cine and T2-weighted CMRIs are used to ass…
Personalized 3D Myocardial Infarct Geometry Reconstruction from Cine MRI with Explicit Cardiac Motion Modeling
Department of Biomedical Engineering, National University of Singapore, Singapore（新加坡国立大学生物医学工程系）；Department of Computer Science, National University of Singapore, Singapore（新加坡国立大学计算机科学系）；Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand（奥克兰大学生物工程研究所）；School of Biomedical Engineering and Imaging Sciences, King’s College London, UK（伦敦国王学院生物医学工程与成像科学学校）；Department of Medicine, National University of Singapore, Singapore（新加坡国立大学医学系）；Department of Cardiology, National University Heart Centre Singapore, Singapore（新加坡国立心脏中心心血管科）
University of Oxford（牛津大学）；Fuzhou University（福州大学）；Fudan University（复旦大学）
Multi-modality cardiac imaging plays a key role in the management of patients with cardiovascular diseases. It allows a combination of complementary anatomical, morphological and functional information, increases diagnosis accuracy, and improves the efficacy of cardiovascular interventions and clinical outcomes. Fully-automated processing and quantitative analysis of multi-modality cardiac images could have a direct impact on clinical research and evidence-based patient management. However, these require overcoming significant challenges including inter-modality misalignment and finding optima…
IMC-PINN-FE: A Physics-Informed Neural Network for Patient-Specific Left Ventricular Finite Element Modeling with Image Motion Consistency and Biomechanical Parameter Estimation
Department of Bioengineering, Imperial College London（帝国理工学院生物工程系）
UT Austin（得克萨斯大学奥斯汀分校）；MIS, Germany（德国曼海姆应用科学大学）；Weill Cornell Medicine（威尔康奈尔医学院）
Computer-aided diagnosis plays a salient role in more accessible and accurate cardiopulmonary diseases classification and localization on chest radiography. Millions of people get affected and die due to these diseases without an accurate and timely diagnosis. Recently proposed contrastive learning heavily relies on data augmentation, especially positive data augmentation. However, generating clinically-accurate data augmentations for medical images is extremely difficult because the common data augmentation methods in computer vision, such as sharp, blur, and crop operations, can severely alt…
Full-field surrogate modeling of cardiac function encoding geometric variability
Institute for Computational and Mathematical Engineering, Stanford University（计算与数学工程研究所，斯坦福大学）；Cardiovascular Institute, Stanford University（心血管研究所，斯坦福大学）；Pediatric Cardiology, Stanford University（儿科心脏病学，斯坦福大学）；Department of BioMechanical Engineering, Delft University of Technology（生物机械工程系，代尔夫特理工大学）；IBiTech-bioMMeda, Ghent University（IBiTech-bioMMeda，根特大学）；Pasteur Labs, Brooklyn, NY 11205, USA（Pasteur实验室，布鲁克林，纽约11205，美国）；Department of Bioengineering, Stanford University（生物工程系，斯坦福大学）
King's College London（伦敦国王学院）；Guy’s and St Thomas' Hospital（盖伊和圣托马斯医院）；University Medical Center Utrecht（乌得勒支大学医学中心）；Royal Brompton Hospital (Guy’s and St Thomas' NHS Foundation Trust)（皇家布朗普顿医院（盖伊和圣托马斯NHS基金会信托））
Left ventricular (LV) function is an important factor in terms of patient management, outcome, and long-term survival of patients with heart disease. The most recently published clinical guidelines for heart failure recognise that over reliance on only one measure of cardiac function (LV ejection fraction) as a diagnostic and treatment stratification biomarker is suboptimal. Recent advances in AI-based echocardiography analysis have shown excellent results on automated estimation of LV volumes and LV ejection fraction. However, from time-varying 2-D echocardiography acquisition, a richer descr…
Delayed-enhancement cardiac magnetic resonance (DE-CMR)provides important diagnostic and prognostic information on myocardial viability. The presence and extent of late gadolinium enhancement (LGE)in DE-CMR is negatively associated with the probability of improvement in left ventricular function after revascularization. Moreover, LGE findings can support the diagnosis of several other cardiomyopathies, but their absence does not rule them out, making disease classification by visual assessment difficult. In this work, we propose deep learning neural networks that can automatically predict myoc…
Memorial Sloan Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）；The University of Queensland（昆士兰大学）；University of Athens Medical School（雅典大学医学院）；IBM Research（IBM研究院）；Universitat de Barcelona（巴塞罗那大学）；IDIBAPS（IDIBAPS（生物医学研究所））；Melanoma Institute Australia（澳大利亚黑色素瘤研究所）；Emory University School of Medicine（埃默里大学医学院）；Medical University of Vienna（维也纳医科大学）；Mayo Clinic（梅奥诊所）；SUNY Downstate Medical School（纽约州立大学唐斯泰特医学院）；Stony Brook Medical School（石溪大学医学院）；Rabin Medical Center（拉宾医疗中心）；Weill Cornell Medical College（威尔康奈尔医学院）
Prior skin image datasets have not addressed patient-level information obtained from multiple skin lesions from the same patient. Though artificial intelligence classification algorithms have achieved expert-level performance in controlled studies examining single images, in practice dermatologists base their judgment holistically from multiple lesions on the same patient. The 2020 SIIM-ISIC Melanoma Classification challenge dataset described herein was constructed to address this discrepancy between prior challenges and clinical practice, providing for each image in the dataset an identifier …
The novel corona virus (Covid-19) has introduced significant challenges due to its rapid spreading nature through respiratory transmission. As a result, there is a huge demand for Artificial Intelligence (AI) based quick disease diagnosis methods as an alternative to high demand tests such as Polymerase Chain Reaction (PCR). Chest X-ray (CXR) Image analysis is such cost-effective radiography technique due to resource availability and quick screening. But, a sufficient and systematic data collection that is required by complex deep leaning (DL) models is more difficult and hence there are recen…
Austin Health（奥斯汀健康）；The University of Melbourne（墨尔本大学）；Kings College London（伦敦国王学院）；I-MED Radiology（I-MED放射科）；University of Porto（波尔图大学）
Objectives: To develop an image-based automatic deep learning method to classify cardiac MR images by sequence type and imaging plane for improved clinical post-processing efficiency. Methods: Multi-vendor cardiac MRI studies were retrospectively collected from 4 centres and 3 vendors. A two-head convolutional neural network ('CardiSort') was trained to classify 35 sequences by imaging sequence (n=17) and plane (n=10). Single vendor training (SVT) on single centre images (n=234 patients) and multi-vendor training (MVT) with multicentre images (n = 479 patients, 3 centres) was performed. Model …
Faculty of Electrical & Computer Engineering, Technion - IIT（以色列理工学院电气与计算机工程学院）；Faculty of Biomedical Engineering, Technion - IIT（以色列理工学院生物医学工程学院）；The May-Blum-Dahl MRI Research Center, Faculty of Biomedical Engineering, Technion - IIT（以色列理工学院生物医学工程学院梅-布-达尔磁共振成像研究中心）；Bnai Zion Medical Center（巴奈锡安医疗中心）
University of Virginia（弗吉尼亚大学）；University of Virginia Health System（弗吉尼亚大学卫生系统）
Automated identification of myocardial scar from late gadolinium enhancement cardiac magnetic resonance images (LGE-CMR) is limited by image noise and artifacts such as those related to motion and partial volume effect. This paper presents a novel joint deep learning (JDL) framework that improves such tasks by utilizing simultaneously learned myocardium segmentations to eliminate negative effects from non-region-of-interest areas. In contrast to previous approaches treating scar detection and myocardium segmentation as separate or parallel tasks, our proposed method introduces a message passin…
Rensselaer Polytechnic Institute（伦斯勒理工学院）；Cedars-Sinai Medical Center（西达赛奈医疗中心）；University of California, Los Angeles（加州大学洛杉矶分校）
Cine cardiac magnetic resonance imaging (MRI) is widely used for diagnosis of cardiac diseases thanks to its ability to present cardiovascular features in excellent contrast. As compared to computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been a strong clinical motivation to develop techniques to reduce both the scan time and motion artifacts. Given its successful applications in other medical imaging tasks such as MRI super-resolution and CT metal artifact reduction, deep learning is a…
Assessment of Clonal Hematopoiesis of Indeterminate Potential and Future Cardiomyopathy from Cardiac Magnetic Resonance Imaging using Deep Learning in a Cardio-oncology Population
Transformer-based cardiac substructure segmentation from contrast and non-contrast computed tomography for radiotherapy planning
Memorial Sloan Kettering Cancer Center（纪念斯隆·凯特琳癌症中心）；Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg（弗莱堡大学医学院大学医学中心）；German Cancer Consortium (DKTK)（德国癌症联盟（DKTK））
In this work we examine the performance enhancement in classification of medical imaging data when image features are combined with associated non-image data. We compare the performance of eight state-of-the-art deep neural networks in classification tasks when using only image features, compared to when these are combined with patient metadata. We utilise transfer learning with networks pretrained on ImageNet used directly as feature extractors and fine tuned on the target domain. Our experiments show that performance can be significantly enhanced with the inclusion of metadata and use interp…
Heidelberg University Hospital（海德堡大学医院）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；German Competence Network for Congenital Heart Defects（德国先天性心脏病能力网络）
Anisotropic multi-slice Cardiac Magnetic Resonance (CMR) Images are conventionally acquired in patient-specific short-axis (SAX) orientation. In specific cardiovascular diseases that affect right ventricular (RV) morphology, acquisitions in standard axial (AX) orientation are preferred by some investigators, due to potential superiority in RV volume measurement for treatment planning. Unfortunately, due to the rare occurrence of these diseases, data in this domain is scarce. Recent research in deep learning-based methods mainly focused on SAX CMR images and they had proven to be very successfu…
Subspace Implicit Neural Representations for Real-Time Cardiac Cine MR Imaging
Technical University of Munich（慕尼黑工业大学）；Helmholtz Munich（亥姆霍兹慕尼黑中心）；University of Tübingen（蒂宾根大学）；University of Michigan（密歇根大学）；Pontificia Universidad Católica de Chile（智利天主教大学）；King’s College London（伦敦国王学院）；Imperial College London（帝国理工学院）
Background: Increased pericardial adipose tissue (PAT) is associated with many types of cardiovascular disease (CVD). Although cardiac magnetic resonance images (CMRI) are often acquired in patients with CVD, there are currently no tools to automatically identify and quantify PAT from CMRI. The aim of this study was to create a neural network to segment PAT from T2-weighted CMRI and explore the correlations between PAT volumes (PATV) and CVD outcomes and mortality. Methods: We trained and tested a deep learning model, PAT-CNN, to segment PAT on T2-weighted cardiac MR images. Using the segmenta…
University of Notre Dame（圣母大学）；Guangdong Cardiovascular Institute（广东省心血管病研究所）；Guangdong Provincial People’s Hospital（广东省人民医院）；Boston Children’s Hospital（波士顿儿童医院）；Harvard Medical School（哈佛医学院）；University of Pittsburgh（匹兹堡大学）
Real-time cardiac magnetic resonance imaging (MRI) plays an increasingly important role in guiding various cardiac interventions. In order to provide better visual assistance, the cine MRI frames need to be segmented on-the-fly to avoid noticeable visual lag. In addition, considering reliability and patient data privacy, the computation is preferably done on local hardware. State-of-the-art MRI segmentation methods mostly focus on accuracy only, and can hardly be adopted for real-time application or on local hardware. In this work, we present the first hardware-aware multi-scale neural archite…
In this work, we attempt the segmentation of cardiac structures in late gadolinium-enhanced (LGE) magnetic resonance images (MRI) using only minimal supervision in a two-step approach. In the first step, we register a small set of five LGE cardiac magnetic resonance (CMR) images with ground truth labels to a set of 40 target LGE CMR images without annotation. Each manually annotated ground truth provides labels of the myocardium and the left ventricle (LV) and right ventricle (RV) cavities, which are used as atlases. After multi-atlas label fusion by majority voting, we possess noisy labels fo…
Unsupervised domain adaptation (UDA) methods intend to reduce the gap between source and target domains by using unlabeled target domain and labeled source domain data, however, in the medical domain, target domain data may not always be easily available, and acquiring new samples is generally time-consuming. This restricts the development of UDA methods for new domains. In this paper, we explore the potential of UDA in a more challenging while realistic scenario where only one unlabeled target patient sample is available. We call it Few-shot Unsupervised Domain adaptation (FUDA). We first gen…
Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；Imperial College London（帝国理工学院）；Universitat de Barcelona（巴塞罗那大学）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Harbin Institute of Technology（哈尔滨工业大学）；Southern University of Science and Technology（南方科技大学）；Technical University of Munich（慕尼黑工业大学）；INRIA（法国国家信息与自动化研究所）；Université Côte d’Azur（蔚蓝海岸大学）；NVIDIA（英伟达）；Xiamen University（厦门大学）；Sichuan University（四川大学）；Tencent AI Lab（腾讯人工智能实验室）
Accurate computing, analysis and modeling of the ventricles and myocardium from medical images are important, especially in the diagnosis and treatment management for patients suffering from myocardial infarction (MI). Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) provides an important protocol to visualize MI. However, automated segmentation of LGE CMR is still challenging, due to the indistinguishable boundaries, heterogeneous intensity distribution and complex enhancement patterns of pathological myocardium from LGE CMR. Furthermore, compared with the other sequences LG…
Uncertainty Quantification for Cardiac Shape Reconstruction with Deep Signed Distance Functions via MCMC methods
Department of Mathematics and Scientific Computing, University of Graz, Austria（格拉茨大学数学与科学计算系，奥地利）；PRIN-PNRR project no. P2022N5ZNP（PRIN-PNRR项目编号P2022N5ZNP）；INdAM-GNCS
Cardiac valve event timing in echocardiography using deep learning and triplane recordings
GE Vingmed Ultrasound；Norwegian University of Science and Technology（挪威科技大学）；Oslo University Hospital, Rikshospitalet（奥斯陆大学医院（雷克沙医院））；University of Oslo（奥斯陆大学）；SINTEF Digital（SINTEF数字研究所）；St. Olavs hospital（圣奥拉夫斯医院）
Neural Implicit Heart Coordinates: 3D cardiac shape reconstruction from sparse segmentations
School of Biomedical Engineering and Imaging Sciences（生物医学工程与成像科学学院）；William Harvey Research Institute, NIHR Barts Biomedical Research Centre（威廉·哈里森研究机构、NIHR巴茨生物医学研究中心）；Simula Research Laboratory（Simula研究实验室）；Department of Informatics（信息学院）；Department of Bioengineering（生物工程学院）；Barts Heart Centre, Barts Health NHS Trust（巴茨心脏中心、巴茨健康 NHS信托）；Technical University of Munich（慕尼黑技术大学）
National University of Singapore（新加坡国立大学）；National University Heart Centre（国立大学心脏中心）；National University Hospital（国立大学医院）
Late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) can directly visualize nonviable myocardium with hyperenhanced intensities with respect to normal myocardium. For heart attack patients, it is crucial to facilitate the decision of appropriate therapy by analyzing and quantifying their LGE CMR images. To achieve accurate quantification, LGE CMR images need to be processed in two steps: segmentation of the myocardium followed by classification of infarcts within the segmented myocardium. However, automatic segmentation is difficult usually due to the intensity heterogeneity of the …
Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg（生物医学工程人工智能系，埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Department of Biomedical Engineering, The Ohio State University（生物医学工程系，俄亥俄州立大学）；Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG（研究与临床转化，磁共振，西门子医疗有限公司）；Division of Cardiovascular Medicine, The Ohio State University（心血管医学系，俄亥俄州立大学）
National Heart, Lung and Blood Institute, National Institutes of Health（美国国立卫生研究院心肺血液研究所）；Barts Heart Centre, Barts Health NHS Trust（巴特健康国民保健信托巴特心脏中心）；National Amyloidosis Centre, Royal Free Hospital（皇家自由医院国家淀粉样变性病中心）
Purpose: To develop a convolutional neural network (CNN) solution for robust landmark detection in cardiac MR images. Methods: This retrospective study included cine, LGE and T1 mapping scans from two hospitals. The training set included 2,329 patients and 34,019 images. A hold-out test set included 531 patients and 7,723 images. CNN models were developed to detect two mitral valve plane and apical points on long-axis (LAX) images. On short-axis (SAX) images, anterior and posterior RV insertion points and LV center were detected. Model outputs were compared to manual labels by two operators fo…
