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arXiv 1606.05901q-bio.PE
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混合种群中竞争代谢途径的共存

Coexistence of competing metabolic pathways in well-mixed populations

Lenin Fernández, André Amado, Fernando Fagundes Ferreira, Paulo R. A. Campos

摘要:

理解为什么具有不同代谢途径的菌株竞争单一限制性资源共存是理论角度内的一个具有挑战性的问题。以前的研究依赖于机制,如组或空间结构,以实现竞争代谢策略之间的稳定共存。然而,即使在不能归因于空间效应的情况下,也已经通过实验报告了共存[遗传{\bf 100},471(2008)]。根据该研究,其中一种菌株排出的毒素可以负责两种菌株类型的稳定维持。我们提出了一个基于资源的模型,其中一个有效的菌株与代谢速率缓慢的第二种菌株类型,提出了一个快速,但效率低下的代谢竞争。此外,该模型假设低效菌株产生毒素作为副产品。这种毒素影响两种不同强度菌株的生长速度。通过对参数空间的广泛探索,我们确定了两种菌株共存的可能性。有趣的是,我们观察到资源流入率在两种菌株类型的维持中起着关键作用。在资源稀缺的情况下,效率低下的人更受青睐,尽管随着资源流入率的增加,共存成为可能,其领域也扩大了。

英文摘要:

Understanding why strains with different metabolic pathways that compete for a single limiting resource coexist is a challenging issue within a theoretical perspective. Previous investigations rely on mechanisms such as group or spatial structuring to achieve a stable coexistence between competing metabolic strategies. Nevertheless, coexistence has been experimentally reported even in situations where it cannot be attributed to spatial effects [Heredity {\bf 100}, 471 (2008)]. According to that study a toxin expelled by one of the strains can be responsible for the stable maintenance of the two strain types. We propose a resource-based model in which an efficient strain with a slow metabolic rate competes with a second strain type which presents a fast but inefficient metabolism. Moreover, the model assumes that the inefficient strain produces a toxin as a byproduct. This toxin affects the growth rate of both strains with different strength. Through an extensive exploration of the parameter space we determine the situations at which the coexistence of the two strains is possible. Interestingly, we observe that the resource influx rate plays a key role in the maintenance of the two strain types. In a scenario of resource scarcity the inefficient is favored, though as the resource influx rate is augmented the coexistence becomes possible and its domain is enlarged.

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