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arXiv 1602.07033math.APcs.NAmath.NAq-bio.PE
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计算大小结构化种群模型稳态及其稳定性的数值框架

A numerical framework for computing steady states of size-structured population models and their stability

University of Colorado, Boulder(科罗拉多大学博尔德分校)

Inom Mirzaev, David M. Bortz

AI总结:

本文提出一种计算一般演化方程稳态近似解的数值框架,用于研究稳态的存在性和稳定性,并通过线性Sinko-Streifer模型和非线性种群平衡方程验证其有效性。

摘要:

结构化种群模型是一类广泛应用于生物系统研究的通用演化方程。许多理论方法可用于确定一般演化方程稳态的存在性和稳定性。然而,除了非常特殊的情况外,找到演化方程的解析稳态解是一个具有挑战性的问题。在本文中,我们开发了一种数值框架,用于计算一般演化方程的稳态近似解,该框架也可用于确定稳态的存在性和稳定性区域。特别是,我们利用Trotter-Kato定理来近似演化方程在有限维空间上的无穷小生成元,从而将演化方程转化为常微分方程组。因此,我们近似并研究了稳态解的渐进行为。我们通过将其应用于已知精确稳态形式的线性Sinko-Streifer结构化种群模型来说明该数值框架的收敛性。为进一步说明本方法的实用性,我们将其应用于非线性种群平衡方程,这是对已知Smoluchowski凝聚-碎裂模型在生物种群中的扩展。我们还展示了该数值框架可用于获得演化方程稳态解的理论稳定性见解。此外,我们开发的开源Python程序可从我们的GitHub仓库(github.com/MathBioCU)免费获取。

英文摘要:

Structured population models are a class of general evolution equations which are widely used in the study of biological systems. Many theoretical methods are available for establishing existence and stability of steady states of general evolution equations. However, except for very special cases, finding an analytical form of stationary solutions for evolution equations is a challenging task. In the present paper, we develop a numerical framework for computing approximations to stationary solutions of general evolution equations, which can also be used to produce existence and stability regions for steady states. In particular, we use the Trotter-Kato Theorem to approximate the infinitesimal generator of an evolution equation on a finite dimensional space, which in turn reduces the evolution equation into a system of ordinary differential equations. Consequently, we approximate and study the asymptotic behavior of stationary solutions. We illustrate the convergence of our numerical framework by applying it to a linear Sinko-Streifer structured population model for which the exact form of the steady state is known. To further illustrate the utility of our approach, we apply our framework to nonlinear population balance equation, which is an extension of well-known Smoluchowksi coagulation-fragmentation model to biological populations. We also demonstrate that our numerical framework can be used to gain insight about the theoretical stability of the stationary solutions of the evolution equations. Furthermore, the open source Python program that we have developed for our numerical simulations is freely available from our Github repository (github.com/MathBioCU).

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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