白细胞边缘化--流体动力学相场模型的计算方法
Margination of white blood cells - a computational approach by a hydrodynamic phase field model
摘要：
我们数值研究白细胞的边缘化，并证明依赖于一些条件，包括红细胞压积，变形的细胞和雷诺数。详细的介观流体动力学Helfrich型模型的推导，验证和用于模拟白细胞的边缘化提供了一个定量的描述。可以确认使用不太详细的模型获得的先前模拟结果，例如，在红细胞压积值的中间范围处白细胞边缘化的最大概率以及随着变形能力的增加而降低的趋势。考虑惯性效应，这在小血管中变得相关，也显示出依赖性，并导致随着雷诺数的增加，白细胞的边缘不太明显。
英文摘要：
We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including hematocrit, the deformability of the cells and the Reynolds number. A detailed mesoscopic hydrodynamic Helfrich-type model is derived, validated and used for the simulations to provides a quantitative description of the margination of white blood cells. Previous simulation results, obtained with less detailed models, could be confirmed, e.g. the largest probability of margination of white blood cells at an intermediate range of hematocrit values and a decreasing tendency with increasing deformability. The consideration of inertia effects, which become of relevance in small vessels, also shows a dependency and leads to less pronounced margination of white blood cells with increasing Reynolds number.
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