血细胞的微尺度磁泳分离
Magnetophoretic separation of blood cells at the microscale
摘要：
我们提出了一种直接和连续分离血浆中的红细胞和白细胞的方法和模型。该方法在微尺度上使用微流体系统来实现，该微流体系统由嵌入在微流体通道下方的集成软磁元件的阵列组成。微系统是被动的，并且通过施加磁化元件的偏置场来激活。一旦被磁化，元件在微通道中产生不均匀的磁场分布，这在血细胞通过微系统时对血细胞产生力。在全血中，白细胞表现为抗磁性微粒，而红细胞根据其血红蛋白的氧合表现出抗磁性或顺磁性行为。我们开发了一个数学模型来预测血细胞在微系统中的运动，该模型考虑了细胞上的主导磁力、流体力和浮力。我们使用该模型来研究红/白细胞的运输，我们的分析表明，微系统能够快速，有效的红/白细胞分离。
英文摘要：
We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic elements embedded beneath a microfluidic channel. The microsystem is passive, and is activated via application of a bias field that magnetizes the elements. Once magnetized, the elements produce a nonuniform magnetic field distribution in the microchannel, which gives rise to a force on blood cells as they pass through the microsystem. In whole blood, white blood cells behave as diamagnetic microparticles while red blood cells exhibit diamagnetic or paramagnetic behavior depending on the oxygenation of their hemoglobin. We develop a mathematical model for predicting the motion of blood cells in the microsystem that takes into account the dominant magnetic, fluidic and buoyant forces on the cells. We use the model to study red/white blood cell transport, and our analysis indicates that the microsystem is capable of rapid and efficient red/white blood cell separation.
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