微量连续磁泳分离血细胞和血浆
Continuous Magnetophoretic Separation of Blood Cells from Plasma at the Microscale
摘要：
我们提出了一种方法，直接和连续分离的红细胞和白细胞从血浆中的微量。该方法在具有磁性功能的微流体系统中实施。微系统内的流体结构由入口和具有多个出口的单个微流体通道组成。磁性功能由横向嵌入并邻近微通道的集成软磁元件阵列提供。这些元件使用外部磁场磁化，并且一旦磁化，它们在血细胞流过微通道时对血细胞产生磁力。在全血中，白细胞（WBC）表现为抗磁性微粒，而红细胞（RBC）表现出抗磁性或顺磁性行为，这取决于其血红蛋白的氧合。我们研究了血细胞通过微通道的运动，使用的数学模型，考虑到细胞上的磁力，流体和重力。我们使用该模型来研究血细胞分离，我们的分析表明，微系统是能够分离白细胞丰富的血浆，脱氧红细胞丰富的血浆和细胞耗尽的血浆到各自的出口。
英文摘要：
We present a method for the direct and continuous separation of red and white blood cells from plasma at the microscale. The method is implemented in a microfluidic system with magnetic functionality. The fluidic structure within the microsystem consists of an inlet and a single microfluidic channel with multiple outlets. The magnetic functionality is provided by an array of integrated soft-magnetic elements that are embedded transverse and adjacent to the microchannel. The elements are magnetized using an external field, and once magnetized they produce a magnetic force on blood cells as they flow through the microchannel. In whole blood, white blood cells (WBCs) behave as diamagnetic microparticles, while red blood cells (RBCs) exhibit diamagnetic or paramagnetic behavior depending on the oxygenation of their hemoglobin. We study the motion of blood cells through the microchannel using a mathematical model that takes into account the magnetic, fluidic and gravitational forces on the cells. We use the model to study blood cell separation, and our analysis indicates that the microsystem is capable of separating WBC-rich plasma, deoxygenated RBC-rich plasma and cell-depleted plasma into respective outlets.
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